Polypharmacy in older adults with human immunodeficiency virus infection compared with the general population

Mercedes Gimeno-Gracia,1 María José Crusells-Canales,2 Francisco Javier Armesto-Gómez,3 Vicente Compaired-Turlán,4 María José Rabanaque-Hernández5 1Pharmacy Department, Lozano Blesa University Clinical Hospital, Aragon Ins...

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Autores principales:	Gimeno-Gracia M, Crusells-Canales MJ, Armesto-Gómez FJ, Compaired-Turlán V, Rabanaque-Hernández MJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	polypharmacy HIV infection aging Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/c4c48ac9f7ea4e378c618284a235bad5
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spelling	oai:doaj.org-article:c4c48ac9f7ea4e378c618284a235bad52021-12-02T08:32:21ZPolypharmacy in older adults with human immunodeficiency virus infection compared with the general population1178-1998https://doaj.org/article/c4c48ac9f7ea4e378c618284a235bad52016-08-01T00:00:00Zhttps://www.dovepress.com/polypharmacy-in-older-adults-with-human-immunodeficiency-virus-infecti-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Mercedes Gimeno-Gracia,1 María José Crusells-Canales,2 Francisco Javier Armesto-Gómez,3 Vicente Compaired-Turlán,4 María José Rabanaque-Hernández5 1Pharmacy Department, Lozano Blesa University Clinical Hospital, Aragon Institute for Health Research, 2Department of Infectious Diseases, Aragon Institute for Health Research, Lozano Blesa University Clinical Hospital, 3Pharmacy Department, Aragon Health Service, 4Pharmacy Department, Lozano Blesa University Clinical Hospital, 5Department of Public Health, University of Zaragoza, Zaragoza, Spain Background: The percentage of older HIV-positive patients is growing, with an increase in age-related comorbidities and concomitant medication. Objectives: To quantify polypharmacy and profile types of non-antiretroviral drugs collected at community pharmacies in 2014 by HIV-positive individuals on antiretroviral therapy and to compare these findings with those of the general population. Methods: HIV-positive patients (n=199) were compared with a group of patients from the general population (n=8,172), aged between 50 and 64 years. The factors compared were prevalence of polypharmacy (≥5 comedications with cumulative defined daily dose [DDD] per drug over 180), percentage of patients who collected each therapeutic class of drug, and median duration for each drug class (based on DDD). Results were stratified by sex. Results: Polypharmacy was more common in HIV-positive males than in the male general population (8.9% vs 4.4%, P=0.010). Polypharmacy was also higher in HIV-positive females than in the female general population (11.3% vs 3.4%, P=0.002). Percentage of HIV-positive patients receiving analgesics, anti-infectives, gastrointestinal drugs, central nervous system (CNS) agents, and respiratory drugs was higher than in the general population, with significant differences between male populations. No differences were observed in proportion of patients receiving cardiovascular drugs. The estimated number of treatment days (median DDDs) were higher in HIV-positive males than in males from the general population for anti-infectives (32.2 vs 20.0, P<0.001) and CNS agents (238.7 vs 120.0, P=0.002). A higher percentage of HIV-positive males than males from the general population received sulfonamides (17.1% vs 1.5%, P<0.001), macrolides (37.1% vs 24.9%, P=0.020), and quinolones (34.3% vs 21.2%, P=0.009). Conclusion: Polypharmacy is more common in HIV-positive older males and females than in similarly aged members of the general population. HIV-positive patients received more CNS drugs and anti-infectives, specifically sulfonamides, macrolides, and quinolones, but there were no differences in the percentage of patients receiving cardiovascular drugs. It is essential to investigate nonantiretroviral therapy medication use in the HIV-positive population to ensure these patients receive appropriate management. Keywords: polypharmacy, HIV infection, agingGimeno-Gracia MCrusells-Canales MJArmesto-Gómez FJCompaired-Turlán VRabanaque-Hernández MJDove Medical PressarticlepolypharmacyHIV infectionagingGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 1149-1157 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	polypharmacy HIV infection aging Geriatrics RC952-954.6
spellingShingle	polypharmacy HIV infection aging Geriatrics RC952-954.6 Gimeno-Gracia M Crusells-Canales MJ Armesto-Gómez FJ Compaired-Turlán V Rabanaque-Hernández MJ Polypharmacy in older adults with human immunodeficiency virus infection compared with the general population
description	Mercedes Gimeno-Gracia,1 María José Crusells-Canales,2 Francisco Javier Armesto-Gómez,3 Vicente Compaired-Turlán,4 María José Rabanaque-Hernández5 1Pharmacy Department, Lozano Blesa University Clinical Hospital, Aragon Institute for Health Research, 2Department of Infectious Diseases, Aragon Institute for Health Research, Lozano Blesa University Clinical Hospital, 3Pharmacy Department, Aragon Health Service, 4Pharmacy Department, Lozano Blesa University Clinical Hospital, 5Department of Public Health, University of Zaragoza, Zaragoza, Spain Background: The percentage of older HIV-positive patients is growing, with an increase in age-related comorbidities and concomitant medication. Objectives: To quantify polypharmacy and profile types of non-antiretroviral drugs collected at community pharmacies in 2014 by HIV-positive individuals on antiretroviral therapy and to compare these findings with those of the general population. Methods: HIV-positive patients (n=199) were compared with a group of patients from the general population (n=8,172), aged between 50 and 64 years. The factors compared were prevalence of polypharmacy (≥5 comedications with cumulative defined daily dose [DDD] per drug over 180), percentage of patients who collected each therapeutic class of drug, and median duration for each drug class (based on DDD). Results were stratified by sex. Results: Polypharmacy was more common in HIV-positive males than in the male general population (8.9% vs 4.4%, P=0.010). Polypharmacy was also higher in HIV-positive females than in the female general population (11.3% vs 3.4%, P=0.002). Percentage of HIV-positive patients receiving analgesics, anti-infectives, gastrointestinal drugs, central nervous system (CNS) agents, and respiratory drugs was higher than in the general population, with significant differences between male populations. No differences were observed in proportion of patients receiving cardiovascular drugs. The estimated number of treatment days (median DDDs) were higher in HIV-positive males than in males from the general population for anti-infectives (32.2 vs 20.0, P<0.001) and CNS agents (238.7 vs 120.0, P=0.002). A higher percentage of HIV-positive males than males from the general population received sulfonamides (17.1% vs 1.5%, P<0.001), macrolides (37.1% vs 24.9%, P=0.020), and quinolones (34.3% vs 21.2%, P=0.009). Conclusion: Polypharmacy is more common in HIV-positive older males and females than in similarly aged members of the general population. HIV-positive patients received more CNS drugs and anti-infectives, specifically sulfonamides, macrolides, and quinolones, but there were no differences in the percentage of patients receiving cardiovascular drugs. It is essential to investigate nonantiretroviral therapy medication use in the HIV-positive population to ensure these patients receive appropriate management. Keywords: polypharmacy, HIV infection, aging
format	article
author	Gimeno-Gracia M Crusells-Canales MJ Armesto-Gómez FJ Compaired-Turlán V Rabanaque-Hernández MJ
author_facet	Gimeno-Gracia M Crusells-Canales MJ Armesto-Gómez FJ Compaired-Turlán V Rabanaque-Hernández MJ
author_sort	Gimeno-Gracia M
title	Polypharmacy in older adults with human immunodeficiency virus infection compared with the general population
title_short	Polypharmacy in older adults with human immunodeficiency virus infection compared with the general population
title_full	Polypharmacy in older adults with human immunodeficiency virus infection compared with the general population
title_fullStr	Polypharmacy in older adults with human immunodeficiency virus infection compared with the general population
title_full_unstemmed	Polypharmacy in older adults with human immunodeficiency virus infection compared with the general population
title_sort	polypharmacy in older adults with human immunodeficiency virus infection compared with the general population
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/c4c48ac9f7ea4e378c618284a235bad5
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Polypharmacy in older adults with human immunodeficiency virus infection compared with the general population

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