Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity

The maintenance of T resident memory (TRM) cells within pulmonary tissues is incompletely understood. Here the authors show that antigen presentation by lung epithelial cells maintains function and phenotype of pulmonary TRM cells within specific locational niches.

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Autores principales:	Anukul T. Shenoy, Carolina Lyon De Ana, Emad I. Arafa, Isabelle Salwig, Kimberly A. Barker, Filiz T. Korkmaz, Aditya Ramanujan, Neelou S. Etesami, Alicia M. Soucy, Ian M. C. Martin, Brian R. Tilton, Anne Hinds, Wesley N. Goltry, Hasmeena Kathuria, Thomas Braun, Matthew R. Jones, Lee J. Quinton, Anna C. Belkina, Joseph P. Mizgerd
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c4c893d49d55411c8e49e957418469ec
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spelling	oai:doaj.org-article:c4c893d49d55411c8e49e957418469ec2021-12-02T18:07:53ZAntigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity10.1038/s41467-021-26045-w2041-1723https://doaj.org/article/c4c893d49d55411c8e49e957418469ec2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26045-whttps://doaj.org/toc/2041-1723The maintenance of T resident memory (TRM) cells within pulmonary tissues is incompletely understood. Here the authors show that antigen presentation by lung epithelial cells maintains function and phenotype of pulmonary TRM cells within specific locational niches.Anukul T. ShenoyCarolina Lyon De AnaEmad I. ArafaIsabelle SalwigKimberly A. BarkerFiliz T. KorkmazAditya RamanujanNeelou S. EtesamiAlicia M. SoucyIan M. C. MartinBrian R. TiltonAnne HindsWesley N. GoltryHasmeena KathuriaThomas BraunMatthew R. JonesLee J. QuintonAnna C. BelkinaJoseph P. MizgerdNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anukul T. Shenoy Carolina Lyon De Ana Emad I. Arafa Isabelle Salwig Kimberly A. Barker Filiz T. Korkmaz Aditya Ramanujan Neelou S. Etesami Alicia M. Soucy Ian M. C. Martin Brian R. Tilton Anne Hinds Wesley N. Goltry Hasmeena Kathuria Thomas Braun Matthew R. Jones Lee J. Quinton Anna C. Belkina Joseph P. Mizgerd Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity
description	The maintenance of T resident memory (TRM) cells within pulmonary tissues is incompletely understood. Here the authors show that antigen presentation by lung epithelial cells maintains function and phenotype of pulmonary TRM cells within specific locational niches.
format	article
author	Anukul T. Shenoy Carolina Lyon De Ana Emad I. Arafa Isabelle Salwig Kimberly A. Barker Filiz T. Korkmaz Aditya Ramanujan Neelou S. Etesami Alicia M. Soucy Ian M. C. Martin Brian R. Tilton Anne Hinds Wesley N. Goltry Hasmeena Kathuria Thomas Braun Matthew R. Jones Lee J. Quinton Anna C. Belkina Joseph P. Mizgerd
author_facet	Anukul T. Shenoy Carolina Lyon De Ana Emad I. Arafa Isabelle Salwig Kimberly A. Barker Filiz T. Korkmaz Aditya Ramanujan Neelou S. Etesami Alicia M. Soucy Ian M. C. Martin Brian R. Tilton Anne Hinds Wesley N. Goltry Hasmeena Kathuria Thomas Braun Matthew R. Jones Lee J. Quinton Anna C. Belkina Joseph P. Mizgerd
author_sort	Anukul T. Shenoy
title	Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity
title_short	Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity
title_full	Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity
title_fullStr	Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity
title_full_unstemmed	Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity
title_sort	antigen presentation by lung epithelial cells directs cd4+ trm cell function and regulates barrier immunity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c4c893d49d55411c8e49e957418469ec
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Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity

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