Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma

Volatile aldehydes can be enriched in esophageal adenocarcinoma patients’ breath. Here, the authors reveal corresponding metabolic changes in EAC tumours, which may be caused by impaired detoxification of endogenous metabolites.

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Autores principales:	Stefan Antonowicz, Zsolt Bodai, Tom Wiggins, Sheraz R. Markar, Piers R. Boshier, Yan Mei Goh, Mina E. Adam, Haonan Lu, Hiromi Kudo, Francesca Rosini, Robert Goldin, Daniela Moralli, Catherine M. Green, Chris J. Peters, Nagy Habib, Hani Gabra, Rebecca C. Fitzgerald, Zoltan Takats, George B. Hanna
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c4cb39fcd5d245a5814461336da92aeb
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spelling	oai:doaj.org-article:c4cb39fcd5d245a5814461336da92aeb2021-12-02T15:52:44ZEndogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma10.1038/s41467-021-21800-52041-1723https://doaj.org/article/c4cb39fcd5d245a5814461336da92aeb2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21800-5https://doaj.org/toc/2041-1723Volatile aldehydes can be enriched in esophageal adenocarcinoma patients’ breath. Here, the authors reveal corresponding metabolic changes in EAC tumours, which may be caused by impaired detoxification of endogenous metabolites.Stefan AntonowiczZsolt BodaiTom WigginsSheraz R. MarkarPiers R. BoshierYan Mei GohMina E. AdamHaonan LuHiromi KudoFrancesca RosiniRobert GoldinDaniela MoralliCatherine M. GreenChris J. PetersNagy HabibHani GabraRebecca C. FitzgeraldZoltan TakatsGeorge B. HannaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stefan Antonowicz Zsolt Bodai Tom Wiggins Sheraz R. Markar Piers R. Boshier Yan Mei Goh Mina E. Adam Haonan Lu Hiromi Kudo Francesca Rosini Robert Goldin Daniela Moralli Catherine M. Green Chris J. Peters Nagy Habib Hani Gabra Rebecca C. Fitzgerald Zoltan Takats George B. Hanna Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma
description	Volatile aldehydes can be enriched in esophageal adenocarcinoma patients’ breath. Here, the authors reveal corresponding metabolic changes in EAC tumours, which may be caused by impaired detoxification of endogenous metabolites.
format	article
author	Stefan Antonowicz Zsolt Bodai Tom Wiggins Sheraz R. Markar Piers R. Boshier Yan Mei Goh Mina E. Adam Haonan Lu Hiromi Kudo Francesca Rosini Robert Goldin Daniela Moralli Catherine M. Green Chris J. Peters Nagy Habib Hani Gabra Rebecca C. Fitzgerald Zoltan Takats George B. Hanna
author_facet	Stefan Antonowicz Zsolt Bodai Tom Wiggins Sheraz R. Markar Piers R. Boshier Yan Mei Goh Mina E. Adam Haonan Lu Hiromi Kudo Francesca Rosini Robert Goldin Daniela Moralli Catherine M. Green Chris J. Peters Nagy Habib Hani Gabra Rebecca C. Fitzgerald Zoltan Takats George B. Hanna
author_sort	Stefan Antonowicz
title	Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma
title_short	Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma
title_full	Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma
title_fullStr	Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma
title_full_unstemmed	Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma
title_sort	endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c4cb39fcd5d245a5814461336da92aeb
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Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma

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