Unilateral vocal nerve resection alters neurogenesis in the avian song system in a region-specific manner.

New neurons born in the adult brain undergo a critical period soon after migration to their site of incorporation. During this time, the behavior of the animal may influence the survival or culling of these cells. In the songbird song system, earlier work suggested that adult-born neurons may be ret...

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Autores principales:	Jake V Aronowitz, Alice Perez, Christopher O'Brien, Siaresh Aziz, Erica Rodriguez, Kobi Wasner, Sissi Ribeiro, Dovounnae Green, Farhana Faruk, Carolyn L Pytte
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c4cf695166b64c1fb69d3bc5881270cb
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id	oai:doaj.org-article:c4cf695166b64c1fb69d3bc5881270cb
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spelling	oai:doaj.org-article:c4cf695166b64c1fb69d3bc5881270cb2021-12-02T20:19:19ZUnilateral vocal nerve resection alters neurogenesis in the avian song system in a region-specific manner.1932-620310.1371/journal.pone.0256709https://doaj.org/article/c4cf695166b64c1fb69d3bc5881270cb2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256709https://doaj.org/toc/1932-6203New neurons born in the adult brain undergo a critical period soon after migration to their site of incorporation. During this time, the behavior of the animal may influence the survival or culling of these cells. In the songbird song system, earlier work suggested that adult-born neurons may be retained in the song motor pathway nucleus HVC with respect to motor progression toward a target song during juvenile song learning, seasonal song restructuring, and experimentally manipulated song variability. However, it is not known whether the quality of song per se, without progressive improvement, may also influence new neuron survival. To test this idea, we experimentally altered song acoustic structure by unilateral denervation of the syrinx, causing a poor quality song. We found no effect of aberrant song on numbers of new neurons in HVC, suggesting that song quality does not influence new neuron culling in this region. However, aberrant song resulted in the loss of left-side dominance in new neurons in the auditory region caudomedial nidopallium (NCM), and a bilateral decrease in new neurons in the basal ganglia nucleus Area X. Thus new neuron culling may be influenced by behavioral feedback in accordance with the function of new neurons within that region. We propose that studying the effects of singing behaviors on new neurons across multiple brain regions that differentially subserve singing may give rise to general rules underlying the regulation of new neuron survival across taxa and brain regions more broadly.Jake V AronowitzAlice PerezChristopher O'BrienSiaresh AzizErica RodriguezKobi WasnerSissi RibeiroDovounnae GreenFarhana FarukCarolyn L PyttePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256709 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jake V Aronowitz Alice Perez Christopher O'Brien Siaresh Aziz Erica Rodriguez Kobi Wasner Sissi Ribeiro Dovounnae Green Farhana Faruk Carolyn L Pytte Unilateral vocal nerve resection alters neurogenesis in the avian song system in a region-specific manner.
description	New neurons born in the adult brain undergo a critical period soon after migration to their site of incorporation. During this time, the behavior of the animal may influence the survival or culling of these cells. In the songbird song system, earlier work suggested that adult-born neurons may be retained in the song motor pathway nucleus HVC with respect to motor progression toward a target song during juvenile song learning, seasonal song restructuring, and experimentally manipulated song variability. However, it is not known whether the quality of song per se, without progressive improvement, may also influence new neuron survival. To test this idea, we experimentally altered song acoustic structure by unilateral denervation of the syrinx, causing a poor quality song. We found no effect of aberrant song on numbers of new neurons in HVC, suggesting that song quality does not influence new neuron culling in this region. However, aberrant song resulted in the loss of left-side dominance in new neurons in the auditory region caudomedial nidopallium (NCM), and a bilateral decrease in new neurons in the basal ganglia nucleus Area X. Thus new neuron culling may be influenced by behavioral feedback in accordance with the function of new neurons within that region. We propose that studying the effects of singing behaviors on new neurons across multiple brain regions that differentially subserve singing may give rise to general rules underlying the regulation of new neuron survival across taxa and brain regions more broadly.
format	article
author	Jake V Aronowitz Alice Perez Christopher O'Brien Siaresh Aziz Erica Rodriguez Kobi Wasner Sissi Ribeiro Dovounnae Green Farhana Faruk Carolyn L Pytte
author_facet	Jake V Aronowitz Alice Perez Christopher O'Brien Siaresh Aziz Erica Rodriguez Kobi Wasner Sissi Ribeiro Dovounnae Green Farhana Faruk Carolyn L Pytte
author_sort	Jake V Aronowitz
title	Unilateral vocal nerve resection alters neurogenesis in the avian song system in a region-specific manner.
title_short	Unilateral vocal nerve resection alters neurogenesis in the avian song system in a region-specific manner.
title_full	Unilateral vocal nerve resection alters neurogenesis in the avian song system in a region-specific manner.
title_fullStr	Unilateral vocal nerve resection alters neurogenesis in the avian song system in a region-specific manner.
title_full_unstemmed	Unilateral vocal nerve resection alters neurogenesis in the avian song system in a region-specific manner.
title_sort	unilateral vocal nerve resection alters neurogenesis in the avian song system in a region-specific manner.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c4cf695166b64c1fb69d3bc5881270cb
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Unilateral vocal nerve resection alters neurogenesis in the avian song system in a region-specific manner.

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