Sfrp3 modulates stromal–epithelial crosstalk during mammary gland development by regulating Wnt levels

The signalling pathways regulating how the mammary gland stroma interacts with the epithelia to then regulate gland development are unclear. Here, the authors identify Sfrp3 as regulating stroma communication via Wnts, on deletion, this increases ductal invasion and initiates an early pregnancy stat...

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Autores principales:	Ilenia Bernascone, Tamara González, Maria D. Barea, Claudia Carabaña, Mariam Hachimi, Minerva Bosch-Fortea, Silvia Santamaria, Raquel Martin, Julia Tarnick, Jose A. Garcia-Sanz, Fernando Martín-Belmonte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c4d0a69819984d5cb45e409bbfe44df3
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spelling	oai:doaj.org-article:c4d0a69819984d5cb45e409bbfe44df32021-12-02T16:58:07ZSfrp3 modulates stromal–epithelial crosstalk during mammary gland development by regulating Wnt levels10.1038/s41467-019-10509-12041-1723https://doaj.org/article/c4d0a69819984d5cb45e409bbfe44df32019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10509-1https://doaj.org/toc/2041-1723The signalling pathways regulating how the mammary gland stroma interacts with the epithelia to then regulate gland development are unclear. Here, the authors identify Sfrp3 as regulating stroma communication via Wnts, on deletion, this increases ductal invasion and initiates an early pregnancy state.Ilenia BernasconeTamara GonzálezMaria D. BareaClaudia CarabañaMariam HachimiMinerva Bosch-ForteaSilvia SantamariaRaquel MartinJulia TarnickJose A. Garcia-SanzFernando Martín-BelmonteNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ilenia Bernascone Tamara González Maria D. Barea Claudia Carabaña Mariam Hachimi Minerva Bosch-Fortea Silvia Santamaria Raquel Martin Julia Tarnick Jose A. Garcia-Sanz Fernando Martín-Belmonte Sfrp3 modulates stromal–epithelial crosstalk during mammary gland development by regulating Wnt levels
description	The signalling pathways regulating how the mammary gland stroma interacts with the epithelia to then regulate gland development are unclear. Here, the authors identify Sfrp3 as regulating stroma communication via Wnts, on deletion, this increases ductal invasion and initiates an early pregnancy state.
format	article
author	Ilenia Bernascone Tamara González Maria D. Barea Claudia Carabaña Mariam Hachimi Minerva Bosch-Fortea Silvia Santamaria Raquel Martin Julia Tarnick Jose A. Garcia-Sanz Fernando Martín-Belmonte
author_facet	Ilenia Bernascone Tamara González Maria D. Barea Claudia Carabaña Mariam Hachimi Minerva Bosch-Fortea Silvia Santamaria Raquel Martin Julia Tarnick Jose A. Garcia-Sanz Fernando Martín-Belmonte
author_sort	Ilenia Bernascone
title	Sfrp3 modulates stromal–epithelial crosstalk during mammary gland development by regulating Wnt levels
title_short	Sfrp3 modulates stromal–epithelial crosstalk during mammary gland development by regulating Wnt levels
title_full	Sfrp3 modulates stromal–epithelial crosstalk during mammary gland development by regulating Wnt levels
title_fullStr	Sfrp3 modulates stromal–epithelial crosstalk during mammary gland development by regulating Wnt levels
title_full_unstemmed	Sfrp3 modulates stromal–epithelial crosstalk during mammary gland development by regulating Wnt levels
title_sort	sfrp3 modulates stromal–epithelial crosstalk during mammary gland development by regulating wnt levels
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c4d0a69819984d5cb45e409bbfe44df3
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Sfrp3 modulates stromal–epithelial crosstalk during mammary gland development by regulating Wnt levels

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