Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade

Endocrinopathies, such as thyroid autoimmunity, are common among patients treated with immune checkpoint inhibitors. Here, by using a polygenic risk score (PRS) derived from a hypothyroidism GWAS, the authors show that cancer patients with high PRS are at increased risk of atezolizumab (anti-PD-L1)-...

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Autores principales:	Zia Khan, Christian Hammer, Jonathan Carroll, Flavia Di Nucci, Sergio Ley Acosta, Vidya Maiya, Tushar Bhangale, Julie Hunkapiller, Ira Mellman, Matthew L. Albert, Mark I. McCarthy, G. Scott Chandler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c4d618dc88c448e799c4accf705c951a
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spelling	oai:doaj.org-article:c4d618dc88c448e799c4accf705c951a2021-12-02T17:47:22ZGenetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade10.1038/s41467-021-23661-42041-1723https://doaj.org/article/c4d618dc88c448e799c4accf705c951a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23661-4https://doaj.org/toc/2041-1723Endocrinopathies, such as thyroid autoimmunity, are common among patients treated with immune checkpoint inhibitors. Here, by using a polygenic risk score (PRS) derived from a hypothyroidism GWAS, the authors show that cancer patients with high PRS are at increased risk of atezolizumab (anti-PD-L1)-induced thyroid dysfunction, a condition associated with systemic response to PD-1 checkpoint blockade and longer overall survival.Zia KhanChristian HammerJonathan CarrollFlavia Di NucciSergio Ley AcostaVidya MaiyaTushar BhangaleJulie HunkapillerIra MellmanMatthew L. AlbertMark I. McCarthyG. Scott ChandlerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zia Khan Christian Hammer Jonathan Carroll Flavia Di Nucci Sergio Ley Acosta Vidya Maiya Tushar Bhangale Julie Hunkapiller Ira Mellman Matthew L. Albert Mark I. McCarthy G. Scott Chandler Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade
description	Endocrinopathies, such as thyroid autoimmunity, are common among patients treated with immune checkpoint inhibitors. Here, by using a polygenic risk score (PRS) derived from a hypothyroidism GWAS, the authors show that cancer patients with high PRS are at increased risk of atezolizumab (anti-PD-L1)-induced thyroid dysfunction, a condition associated with systemic response to PD-1 checkpoint blockade and longer overall survival.
format	article
author	Zia Khan Christian Hammer Jonathan Carroll Flavia Di Nucci Sergio Ley Acosta Vidya Maiya Tushar Bhangale Julie Hunkapiller Ira Mellman Matthew L. Albert Mark I. McCarthy G. Scott Chandler
author_facet	Zia Khan Christian Hammer Jonathan Carroll Flavia Di Nucci Sergio Ley Acosta Vidya Maiya Tushar Bhangale Julie Hunkapiller Ira Mellman Matthew L. Albert Mark I. McCarthy G. Scott Chandler
author_sort	Zia Khan
title	Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade
title_short	Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade
title_full	Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade
title_fullStr	Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade
title_full_unstemmed	Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade
title_sort	genetic variation associated with thyroid autoimmunity shapes the systemic immune response to pd-1 checkpoint blockade
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c4d618dc88c448e799c4accf705c951a
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Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade

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