The Potential of Induced Pluripotent Stem Cells to Advance the Treatment of Pancreatic Ductal Adenocarcinoma

Advances in the treatment of pancreatic ductal adenocarcinoma (PDAC) using neoadjuvant chemoradiotherapy, chemotherapy, and immunotherapy have had minimal impact on the overall survival of patients. A general lack of immunogenic features and a complex tumor microenvironment (TME) are likely culprits...

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Autores principales:	Ricki T. Krog, Noel F. C. C. de Miranda, Alexander L. Vahrmeijer, Nigel G. Kooreman
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pancreatic ductal adenocarcinoma PDAC induced pluripotent stem cells iPSCs cancer models cancer vaccine Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/c4d760c6828849d491c2f1224e656a40
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spelling	oai:doaj.org-article:c4d760c6828849d491c2f1224e656a402021-11-25T17:04:01ZThe Potential of Induced Pluripotent Stem Cells to Advance the Treatment of Pancreatic Ductal Adenocarcinoma10.3390/cancers132257892072-6694https://doaj.org/article/c4d760c6828849d491c2f1224e656a402021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5789https://doaj.org/toc/2072-6694Advances in the treatment of pancreatic ductal adenocarcinoma (PDAC) using neoadjuvant chemoradiotherapy, chemotherapy, and immunotherapy have had minimal impact on the overall survival of patients. A general lack of immunogenic features and a complex tumor microenvironment (TME) are likely culprits for therapy refractoriness in PDAC. Induced pluripotent stem cells (iPSCs) should be explored as a means to advance the treatment options for PDAC, by providing representative in vitro models of pancreatic cancer development. In addition, iPSCs could be used for tailor-made cellular immunotherapies or as a source of tumor-associated antigens in the context of vaccination.Ricki T. KrogNoel F. C. C. de MirandaAlexander L. VahrmeijerNigel G. KooremanMDPI AGarticlepancreatic ductal adenocarcinomaPDACinduced pluripotent stem cellsiPSCscancer modelscancer vaccineNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5789, p 5789 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pancreatic ductal adenocarcinoma PDAC induced pluripotent stem cells iPSCs cancer models cancer vaccine Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	pancreatic ductal adenocarcinoma PDAC induced pluripotent stem cells iPSCs cancer models cancer vaccine Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ricki T. Krog Noel F. C. C. de Miranda Alexander L. Vahrmeijer Nigel G. Kooreman The Potential of Induced Pluripotent Stem Cells to Advance the Treatment of Pancreatic Ductal Adenocarcinoma
description	Advances in the treatment of pancreatic ductal adenocarcinoma (PDAC) using neoadjuvant chemoradiotherapy, chemotherapy, and immunotherapy have had minimal impact on the overall survival of patients. A general lack of immunogenic features and a complex tumor microenvironment (TME) are likely culprits for therapy refractoriness in PDAC. Induced pluripotent stem cells (iPSCs) should be explored as a means to advance the treatment options for PDAC, by providing representative in vitro models of pancreatic cancer development. In addition, iPSCs could be used for tailor-made cellular immunotherapies or as a source of tumor-associated antigens in the context of vaccination.
format	article
author	Ricki T. Krog Noel F. C. C. de Miranda Alexander L. Vahrmeijer Nigel G. Kooreman
author_facet	Ricki T. Krog Noel F. C. C. de Miranda Alexander L. Vahrmeijer Nigel G. Kooreman
author_sort	Ricki T. Krog
title	The Potential of Induced Pluripotent Stem Cells to Advance the Treatment of Pancreatic Ductal Adenocarcinoma
title_short	The Potential of Induced Pluripotent Stem Cells to Advance the Treatment of Pancreatic Ductal Adenocarcinoma
title_full	The Potential of Induced Pluripotent Stem Cells to Advance the Treatment of Pancreatic Ductal Adenocarcinoma
title_fullStr	The Potential of Induced Pluripotent Stem Cells to Advance the Treatment of Pancreatic Ductal Adenocarcinoma
title_full_unstemmed	The Potential of Induced Pluripotent Stem Cells to Advance the Treatment of Pancreatic Ductal Adenocarcinoma
title_sort	potential of induced pluripotent stem cells to advance the treatment of pancreatic ductal adenocarcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c4d760c6828849d491c2f1224e656a40
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The Potential of Induced Pluripotent Stem Cells to Advance the Treatment of Pancreatic Ductal Adenocarcinoma

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