Primary hypothyroidism as a predictor of the hypogonadism development

Background. Human lifestyle significantly affects human health and reproductive functions. The presence of hypothyroidism negatively impacts the health, activity, and reproductive status. This study was aimed to assess hormonal status, metabolic and anthropometric parameters in men of active reprodu...

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Autores principales:	N.V. Pasyechko, T.Y. Krytskyi, S.V. Kadubets, U.V. Naumova, L.V. Naumova
Formato:	article
Lenguaje:	EN RU UK
Publicado:	Publishing House Zaslavsky 2021
Materias:	hypothyroidism, hypogonadism, testosterone, hormonal status, males Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/c4d8dcdebbd04a249476e594b3d66fa4
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spelling	oai:doaj.org-article:c4d8dcdebbd04a249476e594b3d66fa42021-11-22T11:26:20ZPrimary hypothyroidism as a predictor of the hypogonadism development2224-07212307-142710.22141/2224-0721.17.6.2021.243211https://doaj.org/article/c4d8dcdebbd04a249476e594b3d66fa42021-10-01T00:00:00Zhttp://iej.zaslavsky.com.ua/article/view/243211https://doaj.org/toc/2224-0721https://doaj.org/toc/2307-1427Background. Human lifestyle significantly affects human health and reproductive functions. The presence of hypothyroidism negatively impacts the health, activity, and reproductive status. This study was aimed to assess hormonal status, metabolic and anthropometric parameters in men of active reproductive age with primary hypothyroidism. Materials and methods. Totally 60 males with primary hypothyroidism were included in the study. A comparative analysis of hormonal, anthropometric, and metabolic parameters in 60 men with hypothyroidism (basic group) and 25 men without hypothyroidism and other chronic somatic diseases (control group) was performed. The mean age of the subjects was 42.4 ± 2.7 years. Results. It has been established that hypothyroidism was accompanied by an increase in serum concentrations of cholesterol and low-density lipoprotein cholesterol in comparison with control group (25 men without hypothyroidism) indicating metabolic disturbance. The data shows the significant effect of hypothyroidism on testosterone and follicle-stimulating hormone (FSH) serum concentration but not on luteinizing hormone, estradiol levels. Patients with hypothyroidism had lower circulating testosterone and higher FSH level in comparison with the controls. The reproductive hormone changes in men with hypothyroidism can result in deleterious effects on sexual functions including erectile dysfunction, reduced libido, and alteration in spermatogenesis. Conclusions. In men with hypothyroidism, changes in hormonal status have been found, which manifested in a decrease in testosterone and an increase in the blood level of follicle-stimulating hormone. The effect of hypothyroidism on the blood level of other hormones (luteinizing, estradiol, cortisol) has not been established. Hypothyroidism in men is accompanied by changes in lipid metabolism (increased levels of total cholesterol and low-density lipoprotein cholesterol).N.V. PasyechkoT.Y. KrytskyiS.V. KadubetsU.V. NaumovaL.V. NaumovaPublishing House Zaslavskyarticlehypothyroidism, hypogonadism, testosterone, hormonal status, malesDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENRUUKMìžnarodnij Endokrinologìčnij Žurnal, Vol 17, Iss 6, Pp 482-485 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU UK
topic	hypothyroidism, hypogonadism, testosterone, hormonal status, males Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	hypothyroidism, hypogonadism, testosterone, hormonal status, males Diseases of the endocrine glands. Clinical endocrinology RC648-665 N.V. Pasyechko T.Y. Krytskyi S.V. Kadubets U.V. Naumova L.V. Naumova Primary hypothyroidism as a predictor of the hypogonadism development
description	Background. Human lifestyle significantly affects human health and reproductive functions. The presence of hypothyroidism negatively impacts the health, activity, and reproductive status. This study was aimed to assess hormonal status, metabolic and anthropometric parameters in men of active reproductive age with primary hypothyroidism. Materials and methods. Totally 60 males with primary hypothyroidism were included in the study. A comparative analysis of hormonal, anthropometric, and metabolic parameters in 60 men with hypothyroidism (basic group) and 25 men without hypothyroidism and other chronic somatic diseases (control group) was performed. The mean age of the subjects was 42.4 ± 2.7 years. Results. It has been established that hypothyroidism was accompanied by an increase in serum concentrations of cholesterol and low-density lipoprotein cholesterol in comparison with control group (25 men without hypothyroidism) indicating metabolic disturbance. The data shows the significant effect of hypothyroidism on testosterone and follicle-stimulating hormone (FSH) serum concentration but not on luteinizing hormone, estradiol levels. Patients with hypothyroidism had lower circulating testosterone and higher FSH level in comparison with the controls. The reproductive hormone changes in men with hypothyroidism can result in deleterious effects on sexual functions including erectile dysfunction, reduced libido, and alteration in spermatogenesis. Conclusions. In men with hypothyroidism, changes in hormonal status have been found, which manifested in a decrease in testosterone and an increase in the blood level of follicle-stimulating hormone. The effect of hypothyroidism on the blood level of other hormones (luteinizing, estradiol, cortisol) has not been established. Hypothyroidism in men is accompanied by changes in lipid metabolism (increased levels of total cholesterol and low-density lipoprotein cholesterol).
format	article
author	N.V. Pasyechko T.Y. Krytskyi S.V. Kadubets U.V. Naumova L.V. Naumova
author_facet	N.V. Pasyechko T.Y. Krytskyi S.V. Kadubets U.V. Naumova L.V. Naumova
author_sort	N.V. Pasyechko
title	Primary hypothyroidism as a predictor of the hypogonadism development
title_short	Primary hypothyroidism as a predictor of the hypogonadism development
title_full	Primary hypothyroidism as a predictor of the hypogonadism development
title_fullStr	Primary hypothyroidism as a predictor of the hypogonadism development
title_full_unstemmed	Primary hypothyroidism as a predictor of the hypogonadism development
title_sort	primary hypothyroidism as a predictor of the hypogonadism development
publisher	Publishing House Zaslavsky
publishDate	2021
url	https://doaj.org/article/c4d8dcdebbd04a249476e594b3d66fa4
work_keys_str_mv	AT nvpasyechko primaryhypothyroidismasapredictorofthehypogonadismdevelopment AT tykrytskyi primaryhypothyroidismasapredictorofthehypogonadismdevelopment AT svkadubets primaryhypothyroidismasapredictorofthehypogonadismdevelopment AT uvnaumova primaryhypothyroidismasapredictorofthehypogonadismdevelopment AT lvnaumova primaryhypothyroidismasapredictorofthehypogonadismdevelopment
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Primary hypothyroidism as a predictor of the hypogonadism development

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