Higher choroidal thickness and lower choriocapillaris blood flow signal density based on optical coherence tomography angiography in diabetics

Abstract Diabetes mellitus (DM) is one of the fastest growing chronic diseases in the world and one of the main causes of vision loss. Whether or not diabetic choroidopathy (DC) is involved in the initiation and progression of diabetic ocular complications needs to be explored. We included 54 diabet...

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Autores principales:	Yaoli Zhang, Yuanjun Qin, Shuaishuai Wang, Yuyan Liu, Xinyu Li, Xufang Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c4daa819d0e34d1bb6e918965e72ea3e
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spelling	oai:doaj.org-article:c4daa819d0e34d1bb6e918965e72ea3e2021-12-02T13:20:04ZHigher choroidal thickness and lower choriocapillaris blood flow signal density based on optical coherence tomography angiography in diabetics10.1038/s41598-021-85065-02045-2322https://doaj.org/article/c4daa819d0e34d1bb6e918965e72ea3e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85065-0https://doaj.org/toc/2045-2322Abstract Diabetes mellitus (DM) is one of the fastest growing chronic diseases in the world and one of the main causes of vision loss. Whether or not diabetic choroidopathy (DC) is involved in the initiation and progression of diabetic ocular complications needs to be explored. We included 54 diabetic eyes from 36 diabetic patients, and 54 healthy eyes from 32 control subjects after propensity scores matching. All of the subjects were given pupil light and dark adaptation examination and optical coherence tomography angiography (OCTA). Scotopic pupil diameter (SPD), pupil contraction amplitude, and velocity of pupil contraction of the diabetic group were significantly lower than that of the healthy control group (P < 0.05).Choroidal thickness at temporal quadrant (at 750 μm) and superior quadrant (at 1500 μm and 2250 μm) increased in diabetic group compared to control group(P < 0.05).In the diabetic group, choriocapillaris blood flow signal density (CCBFSD) in the macular area (diameter = 2000 μm) were significantly decreased compared with the healthy control group (P < 0.05). Apparent changes in pupil and choroidal blood flow were observed in the diabetic patients.Yaoli ZhangYuanjun QinShuaishuai WangYuyan LiuXinyu LiXufang SunNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yaoli Zhang Yuanjun Qin Shuaishuai Wang Yuyan Liu Xinyu Li Xufang Sun Higher choroidal thickness and lower choriocapillaris blood flow signal density based on optical coherence tomography angiography in diabetics
description	Abstract Diabetes mellitus (DM) is one of the fastest growing chronic diseases in the world and one of the main causes of vision loss. Whether or not diabetic choroidopathy (DC) is involved in the initiation and progression of diabetic ocular complications needs to be explored. We included 54 diabetic eyes from 36 diabetic patients, and 54 healthy eyes from 32 control subjects after propensity scores matching. All of the subjects were given pupil light and dark adaptation examination and optical coherence tomography angiography (OCTA). Scotopic pupil diameter (SPD), pupil contraction amplitude, and velocity of pupil contraction of the diabetic group were significantly lower than that of the healthy control group (P < 0.05).Choroidal thickness at temporal quadrant (at 750 μm) and superior quadrant (at 1500 μm and 2250 μm) increased in diabetic group compared to control group(P < 0.05).In the diabetic group, choriocapillaris blood flow signal density (CCBFSD) in the macular area (diameter = 2000 μm) were significantly decreased compared with the healthy control group (P < 0.05). Apparent changes in pupil and choroidal blood flow were observed in the diabetic patients.
format	article
author	Yaoli Zhang Yuanjun Qin Shuaishuai Wang Yuyan Liu Xinyu Li Xufang Sun
author_facet	Yaoli Zhang Yuanjun Qin Shuaishuai Wang Yuyan Liu Xinyu Li Xufang Sun
author_sort	Yaoli Zhang
title	Higher choroidal thickness and lower choriocapillaris blood flow signal density based on optical coherence tomography angiography in diabetics
title_short	Higher choroidal thickness and lower choriocapillaris blood flow signal density based on optical coherence tomography angiography in diabetics
title_full	Higher choroidal thickness and lower choriocapillaris blood flow signal density based on optical coherence tomography angiography in diabetics
title_fullStr	Higher choroidal thickness and lower choriocapillaris blood flow signal density based on optical coherence tomography angiography in diabetics
title_full_unstemmed	Higher choroidal thickness and lower choriocapillaris blood flow signal density based on optical coherence tomography angiography in diabetics
title_sort	higher choroidal thickness and lower choriocapillaris blood flow signal density based on optical coherence tomography angiography in diabetics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c4daa819d0e34d1bb6e918965e72ea3e
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Higher choroidal thickness and lower choriocapillaris blood flow signal density based on optical coherence tomography angiography in diabetics

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