Extreme inbreeding in a European ancestry sample from the contemporary UK population

Mating between first or second-degree relatives is prohibited in most countries, yet it occurs and is under-studied. Here, Yengo et al. use large runs of homozygosity from the UK Biobank resource to provide DNA-based quantification of extreme inbreeding and its consequence for health and other compl...

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Autores principales:	Loic Yengo, Naomi R. Wray, Peter M. Visscher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c4de637591d1426c8bf1b0307e7f96ad
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spelling	oai:doaj.org-article:c4de637591d1426c8bf1b0307e7f96ad2021-12-02T17:01:52ZExtreme inbreeding in a European ancestry sample from the contemporary UK population10.1038/s41467-019-11724-62041-1723https://doaj.org/article/c4de637591d1426c8bf1b0307e7f96ad2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11724-6https://doaj.org/toc/2041-1723Mating between first or second-degree relatives is prohibited in most countries, yet it occurs and is under-studied. Here, Yengo et al. use large runs of homozygosity from the UK Biobank resource to provide DNA-based quantification of extreme inbreeding and its consequence for health and other complex traits.Loic YengoNaomi R. WrayPeter M. VisscherNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Loic Yengo Naomi R. Wray Peter M. Visscher Extreme inbreeding in a European ancestry sample from the contemporary UK population
description	Mating between first or second-degree relatives is prohibited in most countries, yet it occurs and is under-studied. Here, Yengo et al. use large runs of homozygosity from the UK Biobank resource to provide DNA-based quantification of extreme inbreeding and its consequence for health and other complex traits.
format	article
author	Loic Yengo Naomi R. Wray Peter M. Visscher
author_facet	Loic Yengo Naomi R. Wray Peter M. Visscher
author_sort	Loic Yengo
title	Extreme inbreeding in a European ancestry sample from the contemporary UK population
title_short	Extreme inbreeding in a European ancestry sample from the contemporary UK population
title_full	Extreme inbreeding in a European ancestry sample from the contemporary UK population
title_fullStr	Extreme inbreeding in a European ancestry sample from the contemporary UK population
title_full_unstemmed	Extreme inbreeding in a European ancestry sample from the contemporary UK population
title_sort	extreme inbreeding in a european ancestry sample from the contemporary uk population
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c4de637591d1426c8bf1b0307e7f96ad
work_keys_str_mv	AT loicyengo extremeinbreedinginaeuropeanancestrysamplefromthecontemporaryukpopulation AT naomirwray extremeinbreedinginaeuropeanancestrysamplefromthecontemporaryukpopulation AT petermvisscher extremeinbreedinginaeuropeanancestrysamplefromthecontemporaryukpopulation
_version_	1718382050050834432

Extreme inbreeding in a European ancestry sample from the contemporary UK population

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