Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases

Serum magnesium is associated with osteoporosis and cardiometabolic diseases, but their causal associations remain elusive. We used the two-sample Mendelian randomization (MR) study to explore the causal roles of serum magnesium on osteoporosis and cardiometabolic diseases by using the aggregated ge...

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Autores principales:	Bin He, Liang Xia, Jinqiu Zhao, Lifeng Yin, Muzi Zhang, Zhengxue Quan, Yunsheng Ou, Wei Huang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	serum magnesium lumbar spine BMD osteoporosis cardiometabolic diseases Mendelian randomization study Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/c4dee781c67d41b8b29a8a672765733a
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spelling	oai:doaj.org-article:c4dee781c67d41b8b29a8a672765733a2021-12-03T16:12:38ZCausal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases2296-861X10.3389/fnut.2021.738000https://doaj.org/article/c4dee781c67d41b8b29a8a672765733a2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.738000/fullhttps://doaj.org/toc/2296-861XSerum magnesium is associated with osteoporosis and cardiometabolic diseases, but their causal associations remain elusive. We used the two-sample Mendelian randomization (MR) study to explore the causal roles of serum magnesium on osteoporosis and cardiometabolic diseases by using the aggregated genome-wide association studies (GWASs). Six single-nucleotide polymorphisms (SNPs, p < 5 × 10−8) associated with serum magnesium concentrations were all used as instrumental variables. A genetic predisposition to higher serum magnesium concentrations was inversely associated with lower lumbar spine bone mineral density (BMD, beta-estimate: −1.982, 95% CI: −3.328 to −0.635, SE: 0.687, p = 0.004), which was further confirmed by multiple sensitivity analyses. There was limited evidence of associations between serum magnesium and type 2 diabetes, coronary artery disease, heart failure, and atrial fibrillation. This work provided strong evidence that genetically increased serum magnesium concentrations were causally associated with low lumbar spine BMD and suggested that serum magnesium concentrations may be crucial to prevent osteoporosis.Bin HeLiang XiaJinqiu ZhaoLifeng YinMuzi ZhangZhengxue QuanYunsheng OuWei HuangFrontiers Media S.A.articleserum magnesiumlumbar spine BMDosteoporosiscardiometabolic diseasesMendelian randomization studyNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	serum magnesium lumbar spine BMD osteoporosis cardiometabolic diseases Mendelian randomization study Nutrition. Foods and food supply TX341-641
spellingShingle	serum magnesium lumbar spine BMD osteoporosis cardiometabolic diseases Mendelian randomization study Nutrition. Foods and food supply TX341-641 Bin He Liang Xia Jinqiu Zhao Lifeng Yin Muzi Zhang Zhengxue Quan Yunsheng Ou Wei Huang Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases
description	Serum magnesium is associated with osteoporosis and cardiometabolic diseases, but their causal associations remain elusive. We used the two-sample Mendelian randomization (MR) study to explore the causal roles of serum magnesium on osteoporosis and cardiometabolic diseases by using the aggregated genome-wide association studies (GWASs). Six single-nucleotide polymorphisms (SNPs, p < 5 × 10−8) associated with serum magnesium concentrations were all used as instrumental variables. A genetic predisposition to higher serum magnesium concentrations was inversely associated with lower lumbar spine bone mineral density (BMD, beta-estimate: −1.982, 95% CI: −3.328 to −0.635, SE: 0.687, p = 0.004), which was further confirmed by multiple sensitivity analyses. There was limited evidence of associations between serum magnesium and type 2 diabetes, coronary artery disease, heart failure, and atrial fibrillation. This work provided strong evidence that genetically increased serum magnesium concentrations were causally associated with low lumbar spine BMD and suggested that serum magnesium concentrations may be crucial to prevent osteoporosis.
format	article
author	Bin He Liang Xia Jinqiu Zhao Lifeng Yin Muzi Zhang Zhengxue Quan Yunsheng Ou Wei Huang
author_facet	Bin He Liang Xia Jinqiu Zhao Lifeng Yin Muzi Zhang Zhengxue Quan Yunsheng Ou Wei Huang
author_sort	Bin He
title	Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases
title_short	Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases
title_full	Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases
title_fullStr	Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases
title_full_unstemmed	Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases
title_sort	causal effect of serum magnesium on osteoporosis and cardiometabolic diseases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c4dee781c67d41b8b29a8a672765733a
work_keys_str_mv	AT binhe causaleffectofserummagnesiumonosteoporosisandcardiometabolicdiseases AT liangxia causaleffectofserummagnesiumonosteoporosisandcardiometabolicdiseases AT jinqiuzhao causaleffectofserummagnesiumonosteoporosisandcardiometabolicdiseases AT lifengyin causaleffectofserummagnesiumonosteoporosisandcardiometabolicdiseases AT muzizhang causaleffectofserummagnesiumonosteoporosisandcardiometabolicdiseases AT zhengxuequan causaleffectofserummagnesiumonosteoporosisandcardiometabolicdiseases AT yunshengou causaleffectofserummagnesiumonosteoporosisandcardiometabolicdiseases AT weihuang causaleffectofserummagnesiumonosteoporosisandcardiometabolicdiseases
_version_	1718373172685832192

Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases

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