Clinical and morphological characteristics of wound healing in diabetic foot syndrome

Aim. To assess the clinical and morphological characteristics of neuropathic diabetic foot ulcers (DFUn) Materials and Methods. Forty-three specimens of DFUn were analysed. Depending on the outcome, samples were divided into 2 groups: group 1—healed ulcers (30 samples), group 2&a...

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Autores principales:	Elena Yur'evna Komelyagina, Eugenia Alexandrovna Kogan, Mikhail Borisovich Antsiferov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2017
Materias:	diabetes mellitus diabetic foot syndrom predictors of neuropathic diabetic foot ulcers healing granulation tissue fibrosis ki67 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/c4deec3af8f14a789bdbd57f1891fc75
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spelling	oai:doaj.org-article:c4deec3af8f14a789bdbd57f1891fc752021-11-14T09:00:21ZClinical and morphological characteristics of wound healing in diabetic foot syndrome2072-03512072-037810.14341/7704https://doaj.org/article/c4deec3af8f14a789bdbd57f1891fc752017-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/8190https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To assess the clinical and morphological characteristics of neuropathic diabetic foot ulcers (DFUn) Materials and Methods. Forty-three specimens of DFUn were analysed. Depending on the outcome, samples were divided into 2 groups: group 1—healed ulcers (30 samples), group 2—unhealed ulcers (13 samples). The following characteristics were analysed: age, sex, glycated haemoglobin (HbA1c), ulcer duration, time of admission to the specialised clinic, severity of neuropathy, presence of late complications, plantar localisation, percentage of necrotic tissue, granulation and fibrotic tissue and, Ki-67expression. Results. Patients were similar in age, HbA1c, severity of late complications and plantar localisation. There was a significant difference in the time of admission to the specialised clinic [50 vs 132 days, p = 0.03], percentage of granulation [61 ± 25 vs 32 ± 21 %, р = 0.001] and fibrotic tissue [24 ± 24 vs 49 ± 22 %, р = 0.002], the granulation/fibrosis coefficient [7.5 ± 8.1 vs 1.9 ± 4.6 (%), р = 0,02] and expression of Ki-67 [15 ± 8 vs ± 21 (%), р = 0.001] between groups. A multidimensional model revealed granulation tissue as the main parameter influencing healing. The probability of healing was 1.0 if the percentage of granulation tissue was <50%. If the percentage of granulation tissue was <50%, the prognosis of healing was determined by the expression of Ki-67. When Ki-67 levels were >7%, the probability of healing was 0.75. For Ki-67 levels ≤7%, the probability of healing was 0.17 and the probability of not healing was 0.83. Conclusion. The time at which a patient was admitted to the specialised clinic and the percentage of granulation tissue were key factors affecting the prognosis of wound healing in DFUn.Elena Yur'evna KomelyaginaEugenia Alexandrovna KoganMikhail Borisovich AntsiferovEndocrinology Research Centrearticlediabetes mellitusdiabetic foot syndrompredictors of neuropathic diabetic foot ulcers healinggranulation tissuefibrosiski67Nutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 20, Iss 2, Pp 135-141 (2017)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus diabetic foot syndrom predictors of neuropathic diabetic foot ulcers healing granulation tissue fibrosis ki67 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus diabetic foot syndrom predictors of neuropathic diabetic foot ulcers healing granulation tissue fibrosis ki67 Nutritional diseases. Deficiency diseases RC620-627 Elena Yur'evna Komelyagina Eugenia Alexandrovna Kogan Mikhail Borisovich Antsiferov Clinical and morphological characteristics of wound healing in diabetic foot syndrome
description	Aim. To assess the clinical and morphological characteristics of neuropathic diabetic foot ulcers (DFUn) Materials and Methods. Forty-three specimens of DFUn were analysed. Depending on the outcome, samples were divided into 2 groups: group 1—healed ulcers (30 samples), group 2—unhealed ulcers (13 samples). The following characteristics were analysed: age, sex, glycated haemoglobin (HbA1c), ulcer duration, time of admission to the specialised clinic, severity of neuropathy, presence of late complications, plantar localisation, percentage of necrotic tissue, granulation and fibrotic tissue and, Ki-67expression. Results. Patients were similar in age, HbA1c, severity of late complications and plantar localisation. There was a significant difference in the time of admission to the specialised clinic [50 vs 132 days, p = 0.03], percentage of granulation [61 ± 25 vs 32 ± 21 %, р = 0.001] and fibrotic tissue [24 ± 24 vs 49 ± 22 %, р = 0.002], the granulation/fibrosis coefficient [7.5 ± 8.1 vs 1.9 ± 4.6 (%), р = 0,02] and expression of Ki-67 [15 ± 8 vs ± 21 (%), р = 0.001] between groups. A multidimensional model revealed granulation tissue as the main parameter influencing healing. The probability of healing was 1.0 if the percentage of granulation tissue was <50%. If the percentage of granulation tissue was <50%, the prognosis of healing was determined by the expression of Ki-67. When Ki-67 levels were >7%, the probability of healing was 0.75. For Ki-67 levels ≤7%, the probability of healing was 0.17 and the probability of not healing was 0.83. Conclusion. The time at which a patient was admitted to the specialised clinic and the percentage of granulation tissue were key factors affecting the prognosis of wound healing in DFUn.
format	article
author	Elena Yur'evna Komelyagina Eugenia Alexandrovna Kogan Mikhail Borisovich Antsiferov
author_facet	Elena Yur'evna Komelyagina Eugenia Alexandrovna Kogan Mikhail Borisovich Antsiferov
author_sort	Elena Yur'evna Komelyagina
title	Clinical and morphological characteristics of wound healing in diabetic foot syndrome
title_short	Clinical and morphological characteristics of wound healing in diabetic foot syndrome
title_full	Clinical and morphological characteristics of wound healing in diabetic foot syndrome
title_fullStr	Clinical and morphological characteristics of wound healing in diabetic foot syndrome
title_full_unstemmed	Clinical and morphological characteristics of wound healing in diabetic foot syndrome
title_sort	clinical and morphological characteristics of wound healing in diabetic foot syndrome
publisher	Endocrinology Research Centre
publishDate	2017
url	https://doaj.org/article/c4deec3af8f14a789bdbd57f1891fc75
work_keys_str_mv	AT elenayurevnakomelyagina clinicalandmorphologicalcharacteristicsofwoundhealingindiabeticfootsyndrome AT eugeniaalexandrovnakogan clinicalandmorphologicalcharacteristicsofwoundhealingindiabeticfootsyndrome AT mikhailborisovichantsiferov clinicalandmorphologicalcharacteristicsofwoundhealingindiabeticfootsyndrome
_version_	1718429555455164416

Clinical and morphological characteristics of wound healing in diabetic foot syndrome

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