Mortality among ischemic and nonischemic heart failure patients with a primary implantable cardioverter‐defibrillator

Abstract Background The efficacy of implantable cardioverter defibrillators (ICDs) for primary prevention is controversial in patients with nonischemic heart failure (HF). We evaluated the mortality and predictors of mortality in patients with prophylactic ICD implantation for ischemic and nonischem...

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Autores principales:	Pil‐Sung Yang, Younghyun Kang, Han‐Joon Bae, Jung‐Hoon Sung, Hyung‐Deuk Park, Boyoung Joung
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	defibrillator heart failure ischemic mortality nonischemic Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/c4e106c9ff56406ea75492ba7e81457c
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spelling	oai:doaj.org-article:c4e106c9ff56406ea75492ba7e81457c2021-12-02T08:25:11ZMortality among ischemic and nonischemic heart failure patients with a primary implantable cardioverter‐defibrillator1883-21481880-427610.1002/joa3.12651https://doaj.org/article/c4e106c9ff56406ea75492ba7e81457c2021-12-01T00:00:00Zhttps://doi.org/10.1002/joa3.12651https://doaj.org/toc/1880-4276https://doaj.org/toc/1883-2148Abstract Background The efficacy of implantable cardioverter defibrillators (ICDs) for primary prevention is controversial in patients with nonischemic heart failure (HF). We evaluated the mortality and predictors of mortality in patients with prophylactic ICD implantation for ischemic and nonischemic HF. Methods From 2008 to 2017, 1097 patients (667, nonischemic HF and 430, ischemic HF) who underwent prophylactic ICD implantation, were identified from the Korean National Health Insurance Service database. We used propensity score overlap weighting to correct the differences between two groups. Results Those with ischemic HF were older (67.0 ± 10.1 vs 61.8 ± 14.2 years), more often male (71.4% vs 63.7%), and had more comorbidities than patients with nonischemic HF. During a median follow‐up of 37.3 months (interquartile range [IQR], 14.2‐53.8 months), all‐cause mortality was higher in unweighted patients with ischemic HF than in those with nonischemic HF (10.9 vs 6.4 per 100 person‐years; hazard ratio [HR], 1.74; 95% confidence interval [CI], 1.38‐2.20; P < .001). However, after weighting, the annual all‐cause mortality rate was similar in both groups (9.5 vs 8.8 per 100 person‐years), with no significant difference in the risk of all‐cause mortality (HR, 1.08; 95% CI, 0.68‐1.71; P = .755). Older age and chronic kidney disease were independent predictors of all‐cause mortality in both groups. There was no significant difference in cardiac and noncardiac mortality between the weighted nonischemic and ischemic HF groups. Conclusions The all‐cause, cardiac, and noncardiac mortality rates were similar between patients with nonischemic and ischemic HF who underwent prophylactic ICD implantation.Pil‐Sung YangYounghyun KangHan‐Joon BaeJung‐Hoon SungHyung‐Deuk ParkBoyoung JoungWileyarticledefibrillatorheart failureischemicmortalitynonischemicDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of Arrhythmia, Vol 37, Iss 6, Pp 1537-1545 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	defibrillator heart failure ischemic mortality nonischemic Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	defibrillator heart failure ischemic mortality nonischemic Diseases of the circulatory (Cardiovascular) system RC666-701 Pil‐Sung Yang Younghyun Kang Han‐Joon Bae Jung‐Hoon Sung Hyung‐Deuk Park Boyoung Joung Mortality among ischemic and nonischemic heart failure patients with a primary implantable cardioverter‐defibrillator
description	Abstract Background The efficacy of implantable cardioverter defibrillators (ICDs) for primary prevention is controversial in patients with nonischemic heart failure (HF). We evaluated the mortality and predictors of mortality in patients with prophylactic ICD implantation for ischemic and nonischemic HF. Methods From 2008 to 2017, 1097 patients (667, nonischemic HF and 430, ischemic HF) who underwent prophylactic ICD implantation, were identified from the Korean National Health Insurance Service database. We used propensity score overlap weighting to correct the differences between two groups. Results Those with ischemic HF were older (67.0 ± 10.1 vs 61.8 ± 14.2 years), more often male (71.4% vs 63.7%), and had more comorbidities than patients with nonischemic HF. During a median follow‐up of 37.3 months (interquartile range [IQR], 14.2‐53.8 months), all‐cause mortality was higher in unweighted patients with ischemic HF than in those with nonischemic HF (10.9 vs 6.4 per 100 person‐years; hazard ratio [HR], 1.74; 95% confidence interval [CI], 1.38‐2.20; P < .001). However, after weighting, the annual all‐cause mortality rate was similar in both groups (9.5 vs 8.8 per 100 person‐years), with no significant difference in the risk of all‐cause mortality (HR, 1.08; 95% CI, 0.68‐1.71; P = .755). Older age and chronic kidney disease were independent predictors of all‐cause mortality in both groups. There was no significant difference in cardiac and noncardiac mortality between the weighted nonischemic and ischemic HF groups. Conclusions The all‐cause, cardiac, and noncardiac mortality rates were similar between patients with nonischemic and ischemic HF who underwent prophylactic ICD implantation.
format	article
author	Pil‐Sung Yang Younghyun Kang Han‐Joon Bae Jung‐Hoon Sung Hyung‐Deuk Park Boyoung Joung
author_facet	Pil‐Sung Yang Younghyun Kang Han‐Joon Bae Jung‐Hoon Sung Hyung‐Deuk Park Boyoung Joung
author_sort	Pil‐Sung Yang
title	Mortality among ischemic and nonischemic heart failure patients with a primary implantable cardioverter‐defibrillator
title_short	Mortality among ischemic and nonischemic heart failure patients with a primary implantable cardioverter‐defibrillator
title_full	Mortality among ischemic and nonischemic heart failure patients with a primary implantable cardioverter‐defibrillator
title_fullStr	Mortality among ischemic and nonischemic heart failure patients with a primary implantable cardioverter‐defibrillator
title_full_unstemmed	Mortality among ischemic and nonischemic heart failure patients with a primary implantable cardioverter‐defibrillator
title_sort	mortality among ischemic and nonischemic heart failure patients with a primary implantable cardioverter‐defibrillator
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/c4e106c9ff56406ea75492ba7e81457c
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Mortality among ischemic and nonischemic heart failure patients with a primary implantable cardioverter‐defibrillator

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