The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach
Despite tremendous progress being made in recent years, multiple myeloma (MM) remains a challenging disease. The laboratory plays a critical role in the overall management of patients. The diagnosis, prognosis, clinical monitoring and evaluation of the response are key moments in the clinical care p...
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MDPI AG
2021
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oai:doaj.org-article:c4e255d0d4804062aa087d575fcc2f4c2021-11-25T17:20:50ZThe Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach10.3390/diagnostics111120202075-4418https://doaj.org/article/c4e255d0d4804062aa087d575fcc2f4c2021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2020https://doaj.org/toc/2075-4418Despite tremendous progress being made in recent years, multiple myeloma (MM) remains a challenging disease. The laboratory plays a critical role in the overall management of patients. The diagnosis, prognosis, clinical monitoring and evaluation of the response are key moments in the clinical care process. Conventional laboratory methods have been and continue to be the basis of laboratory testing in monoclonal gammopathies, along with the serum free light chain test. However, more accurate methods are needed to achieve new and more stringent clinical goals. The heavy/light chain assay is a relatively new test which can overcome some of the limitations of the conventional methods for the evaluation of intact immunoglobulin MM patients. Here, we report an update of the evidence accumulated in recent years on this method regarding its use in MM.Rafael Ríos-TamayoNoemí PuigMacarena AlgarínJosé Luís García de Veas SilvaNuno BarbosaCristina EncinasJosé Ángel HernándezRafael AlonsoMaría Luisa CamposTeresa RodríguezAlberto LeivasMaría José OlivaresMaría José SánchezBruno PaivaJuan José LahuertaJoaquín Martínez-LópezMDPI AGarticlemultiple myeloma (MM)heavy/light chain (HLC) assayHevylite<sup>®</sup>diagnosisprognosismonitoringMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2020, p 2020 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
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EN |
| topic |
multiple myeloma (MM) heavy/light chain (HLC) assay Hevylite<sup>®</sup> diagnosis prognosis monitoring Medicine (General) R5-920 |
| spellingShingle |
multiple myeloma (MM) heavy/light chain (HLC) assay Hevylite<sup>®</sup> diagnosis prognosis monitoring Medicine (General) R5-920 Rafael Ríos-Tamayo Noemí Puig Macarena Algarín José Luís García de Veas Silva Nuno Barbosa Cristina Encinas José Ángel Hernández Rafael Alonso María Luisa Campos Teresa Rodríguez Alberto Leivas María José Olivares María José Sánchez Bruno Paiva Juan José Lahuerta Joaquín Martínez-López The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach |
| description |
Despite tremendous progress being made in recent years, multiple myeloma (MM) remains a challenging disease. The laboratory plays a critical role in the overall management of patients. The diagnosis, prognosis, clinical monitoring and evaluation of the response are key moments in the clinical care process. Conventional laboratory methods have been and continue to be the basis of laboratory testing in monoclonal gammopathies, along with the serum free light chain test. However, more accurate methods are needed to achieve new and more stringent clinical goals. The heavy/light chain assay is a relatively new test which can overcome some of the limitations of the conventional methods for the evaluation of intact immunoglobulin MM patients. Here, we report an update of the evidence accumulated in recent years on this method regarding its use in MM. |
| format |
article |
| author |
Rafael Ríos-Tamayo Noemí Puig Macarena Algarín José Luís García de Veas Silva Nuno Barbosa Cristina Encinas José Ángel Hernández Rafael Alonso María Luisa Campos Teresa Rodríguez Alberto Leivas María José Olivares María José Sánchez Bruno Paiva Juan José Lahuerta Joaquín Martínez-López |
| author_facet |
Rafael Ríos-Tamayo Noemí Puig Macarena Algarín José Luís García de Veas Silva Nuno Barbosa Cristina Encinas José Ángel Hernández Rafael Alonso María Luisa Campos Teresa Rodríguez Alberto Leivas María José Olivares María José Sánchez Bruno Paiva Juan José Lahuerta Joaquín Martínez-López |
| author_sort |
Rafael Ríos-Tamayo |
| title |
The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach |
| title_short |
The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach |
| title_full |
The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach |
| title_fullStr |
The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach |
| title_full_unstemmed |
The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach |
| title_sort |
current role of the heavy/light chain assay in the diagnosis, prognosis and monitoring of multiple myeloma: an evidence-based approach |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/c4e255d0d4804062aa087d575fcc2f4c |
| work_keys_str_mv |
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