European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Polygenic risk scores predict the likelihood that an individual will develop a certain cancer, however these are often specific for a given population. Here, the authors show that a risk score developed to assess the risk of breast cancer in European women can also predict risk in Asian populations.

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Autores principales:	Weang-Kee Ho, Min-Min Tan, Nasim Mavaddat, Mei-Chee Tai, Shivaani Mariapun, Jingmei Li, Peh-Joo Ho, Joe Dennis, Jonathan P. Tyrer, Manjeet K. Bolla, Kyriaki Michailidou, Qin Wang, Daehee Kang, Ji-Yeob Choi, Suniza Jamaris, Xiao-Ou Shu, Sook-Yee Yoon, Sue K. Park, Sung-Won Kim, Chen-Yang Shen, Jyh-Cherng Yu, Ern Yu Tan, Patrick Mun Yew Chan, Kenneth Muir, Artitaya Lophatananon, Anna H. Wu, Daniel O. Stram, Keitaro Matsuo, Hidemi Ito, Ching Wan Chan, Joanne Ngeow, Wei Sean Yong, Swee Ho Lim, Geok Hoon Lim, Ava Kwong, Tsun L. Chan, Su Ming Tan, Jaime Seah, Esther M. John, Allison W. Kurian, Woon-Puay Koh, Chiea Chuen Khor, Motoki Iwasaki, Taiki Yamaji, Kiak Mien Veronique Tan, Kiat Tee Benita Tan, John J. Spinelli, Kristan J. Aronson, Siti Norhidayu Hasan, Kartini Rahmat, Anushya Vijayananthan, Xueling Sim, Paul D. P. Pharoah, Wei Zheng, Alison M. Dunning, Jacques Simard, Rob Martinus van Dam, Cheng-Har Yip, Nur Aishah Mohd Taib, Mikael Hartman, Douglas F. Easton, Soo-Hwang Teo, Antonis C. Antoniou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c4e3ab2174674348a51d28c57a00ccd1
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spelling	oai:doaj.org-article:c4e3ab2174674348a51d28c57a00ccd12021-12-02T18:47:08ZEuropean polygenic risk score for prediction of breast cancer shows similar performance in Asian women10.1038/s41467-020-17680-w2041-1723https://doaj.org/article/c4e3ab2174674348a51d28c57a00ccd12020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17680-whttps://doaj.org/toc/2041-1723Polygenic risk scores predict the likelihood that an individual will develop a certain cancer, however these are often specific for a given population. Here, the authors show that a risk score developed to assess the risk of breast cancer in European women can also predict risk in Asian populations.Weang-Kee HoMin-Min TanNasim MavaddatMei-Chee TaiShivaani MariapunJingmei LiPeh-Joo HoJoe DennisJonathan P. TyrerManjeet K. BollaKyriaki MichailidouQin WangDaehee KangJi-Yeob ChoiSuniza JamarisXiao-Ou ShuSook-Yee YoonSue K. ParkSung-Won KimChen-Yang ShenJyh-Cherng YuErn Yu TanPatrick Mun Yew ChanKenneth MuirArtitaya LophatananonAnna H. WuDaniel O. StramKeitaro MatsuoHidemi ItoChing Wan ChanJoanne NgeowWei Sean YongSwee Ho LimGeok Hoon LimAva KwongTsun L. ChanSu Ming TanJaime SeahEsther M. JohnAllison W. KurianWoon-Puay KohChiea Chuen KhorMotoki IwasakiTaiki YamajiKiak Mien Veronique TanKiat Tee Benita TanJohn J. SpinelliKristan J. AronsonSiti Norhidayu HasanKartini RahmatAnushya VijayananthanXueling SimPaul D. P. PharoahWei ZhengAlison M. DunningJacques SimardRob Martinus van DamCheng-Har YipNur Aishah Mohd TaibMikael HartmanDouglas F. EastonSoo-Hwang TeoAntonis C. AntoniouNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Weang-Kee Ho Min-Min Tan Nasim Mavaddat Mei-Chee Tai Shivaani Mariapun Jingmei Li Peh-Joo Ho Joe Dennis Jonathan P. Tyrer Manjeet K. Bolla Kyriaki Michailidou Qin Wang Daehee Kang Ji-Yeob Choi Suniza Jamaris Xiao-Ou Shu Sook-Yee Yoon Sue K. Park Sung-Won Kim Chen-Yang Shen Jyh-Cherng Yu Ern Yu Tan Patrick Mun Yew Chan Kenneth Muir Artitaya Lophatananon Anna H. Wu Daniel O. Stram Keitaro Matsuo Hidemi Ito Ching Wan Chan Joanne Ngeow Wei Sean Yong Swee Ho Lim Geok Hoon Lim Ava Kwong Tsun L. Chan Su Ming Tan Jaime Seah Esther M. John Allison W. Kurian Woon-Puay Koh Chiea Chuen Khor Motoki Iwasaki Taiki Yamaji Kiak Mien Veronique Tan Kiat Tee Benita Tan John J. Spinelli Kristan J. Aronson Siti Norhidayu Hasan Kartini Rahmat Anushya Vijayananthan Xueling Sim Paul D. P. Pharoah Wei Zheng Alison M. Dunning Jacques Simard Rob Martinus van Dam Cheng-Har Yip Nur Aishah Mohd Taib Mikael Hartman Douglas F. Easton Soo-Hwang Teo Antonis C. Antoniou European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
description	Polygenic risk scores predict the likelihood that an individual will develop a certain cancer, however these are often specific for a given population. Here, the authors show that a risk score developed to assess the risk of breast cancer in European women can also predict risk in Asian populations.
format	article
author	Weang-Kee Ho Min-Min Tan Nasim Mavaddat Mei-Chee Tai Shivaani Mariapun Jingmei Li Peh-Joo Ho Joe Dennis Jonathan P. Tyrer Manjeet K. Bolla Kyriaki Michailidou Qin Wang Daehee Kang Ji-Yeob Choi Suniza Jamaris Xiao-Ou Shu Sook-Yee Yoon Sue K. Park Sung-Won Kim Chen-Yang Shen Jyh-Cherng Yu Ern Yu Tan Patrick Mun Yew Chan Kenneth Muir Artitaya Lophatananon Anna H. Wu Daniel O. Stram Keitaro Matsuo Hidemi Ito Ching Wan Chan Joanne Ngeow Wei Sean Yong Swee Ho Lim Geok Hoon Lim Ava Kwong Tsun L. Chan Su Ming Tan Jaime Seah Esther M. John Allison W. Kurian Woon-Puay Koh Chiea Chuen Khor Motoki Iwasaki Taiki Yamaji Kiak Mien Veronique Tan Kiat Tee Benita Tan John J. Spinelli Kristan J. Aronson Siti Norhidayu Hasan Kartini Rahmat Anushya Vijayananthan Xueling Sim Paul D. P. Pharoah Wei Zheng Alison M. Dunning Jacques Simard Rob Martinus van Dam Cheng-Har Yip Nur Aishah Mohd Taib Mikael Hartman Douglas F. Easton Soo-Hwang Teo Antonis C. Antoniou
author_facet	Weang-Kee Ho Min-Min Tan Nasim Mavaddat Mei-Chee Tai Shivaani Mariapun Jingmei Li Peh-Joo Ho Joe Dennis Jonathan P. Tyrer Manjeet K. Bolla Kyriaki Michailidou Qin Wang Daehee Kang Ji-Yeob Choi Suniza Jamaris Xiao-Ou Shu Sook-Yee Yoon Sue K. Park Sung-Won Kim Chen-Yang Shen Jyh-Cherng Yu Ern Yu Tan Patrick Mun Yew Chan Kenneth Muir Artitaya Lophatananon Anna H. Wu Daniel O. Stram Keitaro Matsuo Hidemi Ito Ching Wan Chan Joanne Ngeow Wei Sean Yong Swee Ho Lim Geok Hoon Lim Ava Kwong Tsun L. Chan Su Ming Tan Jaime Seah Esther M. John Allison W. Kurian Woon-Puay Koh Chiea Chuen Khor Motoki Iwasaki Taiki Yamaji Kiak Mien Veronique Tan Kiat Tee Benita Tan John J. Spinelli Kristan J. Aronson Siti Norhidayu Hasan Kartini Rahmat Anushya Vijayananthan Xueling Sim Paul D. P. Pharoah Wei Zheng Alison M. Dunning Jacques Simard Rob Martinus van Dam Cheng-Har Yip Nur Aishah Mohd Taib Mikael Hartman Douglas F. Easton Soo-Hwang Teo Antonis C. Antoniou
author_sort	Weang-Kee Ho
title	European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
title_short	European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
title_full	European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
title_fullStr	European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
title_full_unstemmed	European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
title_sort	european polygenic risk score for prediction of breast cancer shows similar performance in asian women
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c4e3ab2174674348a51d28c57a00ccd1
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European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

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