Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma

There is still no consensus on tumour type-specific cancer stem cell markers. Here, the authors demonstrate that ITGA7 is a potential functional marker of oesophageal cancer stem cells involved in the resistance to chemotherapy and metastasis through activation of FAK-mediated signalling.

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Detalles Bibliográficos
Autores principales: Xiao-Yan Ming, Li Fu, Li-Yi Zhang, Yan-Ru Qin, Ting-Ting Cao, Kwok Wah Chan, Stephanie Ma, Dan Xie, Xin-Yuan Guan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/c4e41a7639424cc9a91de517acbe0487
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Sumario:There is still no consensus on tumour type-specific cancer stem cell markers. Here, the authors demonstrate that ITGA7 is a potential functional marker of oesophageal cancer stem cells involved in the resistance to chemotherapy and metastasis through activation of FAK-mediated signalling.