The Discordance between Network Excitability and Cognitive Performance Following Vigabatrin Treatment during Epileptogenesis

Vigabatrin (VGB), a potent selective γ-aminobutyric acid transaminase (GABA-T) inhibitor, is an approved non-traditional anti-seizure drug for patients with intractable epilepsy. Nevertheless, its effect on epileptogenesis, and whether this effect is correlated with post-epileptogenic cognitive func...

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Autores principales:	Ming-Chi Lai, Chin-Wei Huang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vigabatrin pilocarpine epileptogenesis cognition Science Q
Acceso en línea:	https://doaj.org/article/c4e46054a88149b69bef0a4758b640c2
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spelling	oai:doaj.org-article:c4e46054a88149b69bef0a4758b640c22021-11-25T18:11:15ZThe Discordance between Network Excitability and Cognitive Performance Following Vigabatrin Treatment during Epileptogenesis10.3390/life111112132075-1729https://doaj.org/article/c4e46054a88149b69bef0a4758b640c22021-11-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1213https://doaj.org/toc/2075-1729Vigabatrin (VGB), a potent selective γ-aminobutyric acid transaminase (GABA-T) inhibitor, is an approved non-traditional anti-seizure drug for patients with intractable epilepsy. Nevertheless, its effect on epileptogenesis, and whether this effect is correlated with post-epileptogenic cognitive function remain unclear. Based on lithium-pilocarpine-induced seizure modeling, we evaluated the effect of VGB on epileptogenesis and neuronal damage following status epilepticus in Sprague–Dawley rats. Cognitive evaluations were performed with the aid of inhibitory avoidance testing. We found that VGB could interrupt epileptogenesis by reducing spontaneous recurrent seizures, hippocampal neuronal damage, and chronic mossy fiber sprouting. Nevertheless, VGB did not help with the retention of cognitive performance. Our findings suggest that further research into the role of VGB in epileptogenesis and the treatment of epilepsy in clinical practice is warranted.Ming-Chi LaiChin-Wei HuangMDPI AGarticlevigabatrinpilocarpineepileptogenesiscognitionScienceQENLife, Vol 11, Iss 1213, p 1213 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vigabatrin pilocarpine epileptogenesis cognition Science Q
spellingShingle	vigabatrin pilocarpine epileptogenesis cognition Science Q Ming-Chi Lai Chin-Wei Huang The Discordance between Network Excitability and Cognitive Performance Following Vigabatrin Treatment during Epileptogenesis
description	Vigabatrin (VGB), a potent selective γ-aminobutyric acid transaminase (GABA-T) inhibitor, is an approved non-traditional anti-seizure drug for patients with intractable epilepsy. Nevertheless, its effect on epileptogenesis, and whether this effect is correlated with post-epileptogenic cognitive function remain unclear. Based on lithium-pilocarpine-induced seizure modeling, we evaluated the effect of VGB on epileptogenesis and neuronal damage following status epilepticus in Sprague–Dawley rats. Cognitive evaluations were performed with the aid of inhibitory avoidance testing. We found that VGB could interrupt epileptogenesis by reducing spontaneous recurrent seizures, hippocampal neuronal damage, and chronic mossy fiber sprouting. Nevertheless, VGB did not help with the retention of cognitive performance. Our findings suggest that further research into the role of VGB in epileptogenesis and the treatment of epilepsy in clinical practice is warranted.
format	article
author	Ming-Chi Lai Chin-Wei Huang
author_facet	Ming-Chi Lai Chin-Wei Huang
author_sort	Ming-Chi Lai
title	The Discordance between Network Excitability and Cognitive Performance Following Vigabatrin Treatment during Epileptogenesis
title_short	The Discordance between Network Excitability and Cognitive Performance Following Vigabatrin Treatment during Epileptogenesis
title_full	The Discordance between Network Excitability and Cognitive Performance Following Vigabatrin Treatment during Epileptogenesis
title_fullStr	The Discordance between Network Excitability and Cognitive Performance Following Vigabatrin Treatment during Epileptogenesis
title_full_unstemmed	The Discordance between Network Excitability and Cognitive Performance Following Vigabatrin Treatment during Epileptogenesis
title_sort	discordance between network excitability and cognitive performance following vigabatrin treatment during epileptogenesis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c4e46054a88149b69bef0a4758b640c2
work_keys_str_mv	AT mingchilai thediscordancebetweennetworkexcitabilityandcognitiveperformancefollowingvigabatrintreatmentduringepileptogenesis AT chinweihuang thediscordancebetweennetworkexcitabilityandcognitiveperformancefollowingvigabatrintreatmentduringepileptogenesis AT mingchilai discordancebetweennetworkexcitabilityandcognitiveperformancefollowingvigabatrintreatmentduringepileptogenesis AT chinweihuang discordancebetweennetworkexcitabilityandcognitiveperformancefollowingvigabatrintreatmentduringepileptogenesis
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The Discordance between Network Excitability and Cognitive Performance Following Vigabatrin Treatment during Epileptogenesis

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