Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: A cross-sectional study.

Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: A cross-sectional study.

<h4>Background</h4>The leading cause of mortality for patients with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome is the development of malignant peripheral nerve sheath tumor (MPNST), an aggressive soft tissue sarcoma. In the setting of NF1, this cancer type frequent...

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Autores principales: Jeffrey J Szymanski, R Taylor Sundby, Paul A Jones, Divya Srihari, Noah Earland, Peter K Harris, Wenjia Feng, Faridi Qaium, Haiyan Lei, David Roberts, Michele Landeau, Jamie Bell, Yi Huang, Leah Hoffman, Melissa Spencer, Matthew B Spraker, Li Ding, Brigitte C Widemann, Jack F Shern, Angela C Hirbe, Aadel A Chaudhuri
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
R
Acceso en línea:https://doaj.org/article/c4e51b3f384e4d0d940d39076a2a352f
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