A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells

The human genome contains thousands of long noncoding RNAs which have been preserved by evolution, through their functions are poorly described. Here the authors show that NORAD binds the Pumilo homologues PUM1 and PUM2 to regulate mRNA levels of genes involved in chromosome segregation.

Guardado en:

Detalles Bibliográficos
Autores principales:	Ailone Tichon, Noa Gil, Yoav Lubelsky, Tal Havkin Solomon, Doron Lemze, Shalev Itzkovitz, Noam Stern-Ginossar, Igor Ulitsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c4e54626b1c44e99b317f4e91b413c99
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c4e54626b1c44e99b317f4e91b413c99
record_format	dspace
spelling	oai:doaj.org-article:c4e54626b1c44e99b317f4e91b413c992021-12-02T14:40:14ZA conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells10.1038/ncomms122092041-1723https://doaj.org/article/c4e54626b1c44e99b317f4e91b413c992016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12209https://doaj.org/toc/2041-1723The human genome contains thousands of long noncoding RNAs which have been preserved by evolution, through their functions are poorly described. Here the authors show that NORAD binds the Pumilo homologues PUM1 and PUM2 to regulate mRNA levels of genes involved in chromosome segregation.Ailone TichonNoa GilYoav LubelskyTal Havkin SolomonDoron LemzeShalev ItzkovitzNoam Stern-GinossarIgor UlitskyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ailone Tichon Noa Gil Yoav Lubelsky Tal Havkin Solomon Doron Lemze Shalev Itzkovitz Noam Stern-Ginossar Igor Ulitsky A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells
description	The human genome contains thousands of long noncoding RNAs which have been preserved by evolution, through their functions are poorly described. Here the authors show that NORAD binds the Pumilo homologues PUM1 and PUM2 to regulate mRNA levels of genes involved in chromosome segregation.
format	article
author	Ailone Tichon Noa Gil Yoav Lubelsky Tal Havkin Solomon Doron Lemze Shalev Itzkovitz Noam Stern-Ginossar Igor Ulitsky
author_facet	Ailone Tichon Noa Gil Yoav Lubelsky Tal Havkin Solomon Doron Lemze Shalev Itzkovitz Noam Stern-Ginossar Igor Ulitsky
author_sort	Ailone Tichon
title	A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells
title_short	A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells
title_full	A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells
title_fullStr	A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells
title_full_unstemmed	A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells
title_sort	conserved abundant cytoplasmic long noncoding rna modulates repression by pumilio proteins in human cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c4e54626b1c44e99b317f4e91b413c99
work_keys_str_mv	AT ailonetichon aconservedabundantcytoplasmiclongnoncodingrnamodulatesrepressionbypumilioproteinsinhumancells AT noagil aconservedabundantcytoplasmiclongnoncodingrnamodulatesrepressionbypumilioproteinsinhumancells AT yoavlubelsky aconservedabundantcytoplasmiclongnoncodingrnamodulatesrepressionbypumilioproteinsinhumancells AT talhavkinsolomon aconservedabundantcytoplasmiclongnoncodingrnamodulatesrepressionbypumilioproteinsinhumancells AT doronlemze aconservedabundantcytoplasmiclongnoncodingrnamodulatesrepressionbypumilioproteinsinhumancells AT shalevitzkovitz aconservedabundantcytoplasmiclongnoncodingrnamodulatesrepressionbypumilioproteinsinhumancells AT noamsternginossar aconservedabundantcytoplasmiclongnoncodingrnamodulatesrepressionbypumilioproteinsinhumancells AT igorulitsky aconservedabundantcytoplasmiclongnoncodingrnamodulatesrepressionbypumilioproteinsinhumancells AT ailonetichon conservedabundantcytoplasmiclongnoncodingrnamodulatesrepressionbypumilioproteinsinhumancells AT noagil conservedabundantcytoplasmiclongnoncodingrnamodulatesrepressionbypumilioproteinsinhumancells AT yoavlubelsky conservedabundantcytoplasmiclongnoncodingrnamodulatesrepressionbypumilioproteinsinhumancells AT talhavkinsolomon conservedabundantcytoplasmiclongnoncodingrnamodulatesrepressionbypumilioproteinsinhumancells AT doronlemze conservedabundantcytoplasmiclongnoncodingrnamodulatesrepressionbypumilioproteinsinhumancells AT shalevitzkovitz conservedabundantcytoplasmiclongnoncodingrnamodulatesrepressionbypumilioproteinsinhumancells AT noamsternginossar conservedabundantcytoplasmiclongnoncodingrnamodulatesrepressionbypumilioproteinsinhumancells AT igorulitsky conservedabundantcytoplasmiclongnoncodingrnamodulatesrepressionbypumilioproteinsinhumancells
_version_	1718390383375810560

A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells

Ejemplares similares