A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells

A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells

The human genome contains thousands of long noncoding RNAs which have been preserved by evolution, through their functions are poorly described. Here the authors show that NORAD binds the Pumilo homologues PUM1 and PUM2 to regulate mRNA levels of genes involved in chromosome segregation.

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Autores principales: Ailone Tichon, Noa Gil, Yoav Lubelsky, Tal Havkin Solomon, Doron Lemze, Shalev Itzkovitz, Noam Stern-Ginossar, Igor Ulitsky
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/c4e54626b1c44e99b317f4e91b413c99
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