The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets

The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets

Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) display heterogeneous clinical and genetic characteristics. Here, the authors investigate the mutational landscape of 85 aNEN by whole genome sequencing and identify distinct subpopulations, tumour mutational burden patterns, drivers an...

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Autores principales: Job van Riet, Harmen J. G. van de Werken, Edwin Cuppen, Ferry A. L. M. Eskens, Margot Tesselaar, Linde M. van Veenendaal, Heinz-Josef Klümpen, Marcus W. Dercksen, Gerlof D. Valk, Martijn P. Lolkema, Stefan Sleijfer, Bianca Mostert
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c4e59c95fe6b477fbcc18e6c64953ba9
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spelling oai:doaj.org-article:c4e59c95fe6b477fbcc18e6c64953ba92021-12-02T16:25:00ZThe genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets10.1038/s41467-021-24812-32041-1723https://doaj.org/article/c4e59c95fe6b477fbcc18e6c64953ba92021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24812-3https://doaj.org/toc/2041-1723Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) display heterogeneous clinical and genetic characteristics. Here, the authors investigate the mutational landscape of 85 aNEN by whole genome sequencing and identify distinct subpopulations, tumour mutational burden patterns, drivers and actionable somatic alterations.Job van RietHarmen J. G. van de WerkenEdwin CuppenFerry A. L. M. EskensMargot TesselaarLinde M. van VeenendaalHeinz-Josef KlümpenMarcus W. DercksenGerlof D. ValkMartijn P. LolkemaStefan SleijferBianca MostertNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Job van Riet
Harmen J. G. van de Werken
Edwin Cuppen
Ferry A. L. M. Eskens
Margot Tesselaar
Linde M. van Veenendaal
Heinz-Josef Klümpen
Marcus W. Dercksen
Gerlof D. Valk
Martijn P. Lolkema
Stefan Sleijfer
Bianca Mostert
The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets
description Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) display heterogeneous clinical and genetic characteristics. Here, the authors investigate the mutational landscape of 85 aNEN by whole genome sequencing and identify distinct subpopulations, tumour mutational burden patterns, drivers and actionable somatic alterations.
format article
author Job van Riet
Harmen J. G. van de Werken
Edwin Cuppen
Ferry A. L. M. Eskens
Margot Tesselaar
Linde M. van Veenendaal
Heinz-Josef Klümpen
Marcus W. Dercksen
Gerlof D. Valk
Martijn P. Lolkema
Stefan Sleijfer
Bianca Mostert
author_facet Job van Riet
Harmen J. G. van de Werken
Edwin Cuppen
Ferry A. L. M. Eskens
Margot Tesselaar
Linde M. van Veenendaal
Heinz-Josef Klümpen
Marcus W. Dercksen
Gerlof D. Valk
Martijn P. Lolkema
Stefan Sleijfer
Bianca Mostert
author_sort Job van Riet
title The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets
title_short The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets
title_full The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets
title_fullStr The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets
title_full_unstemmed The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets
title_sort genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c4e59c95fe6b477fbcc18e6c64953ba9
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