Associations between back pain across adulthood and spine shape in early old age in a British birth cohort

Abstract We aimed to examine whether back pain across adulthood was associated with spine shape at age 60–64 years. Data were from 1405 participants in the MRC National Survey of Health and Development, a nationally representative British birth cohort. Back pain was ascertained during nurse intervie...

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Autores principales:	Stella G. Muthuri, Anastasia V. Pavlova, Fiona R. Saunders, Rebecca J. Hardy, Jennifer S. Gregory, Rebecca J. Barr, Kathryn R. Martin, Judith E. Adams, Diana Kuh, Richard M. Aspden, Rachel Cooper
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Spine Shape Back Pain Reports Small Disk Space National Survey Of Health And Development (NSHD) Statistical Shape Modelling (SSM) Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c4e8db67720e4dfeaa7c48284873b70b
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spelling	oai:doaj.org-article:c4e8db67720e4dfeaa7c48284873b70b2021-12-02T15:08:13ZAssociations between back pain across adulthood and spine shape in early old age in a British birth cohort10.1038/s41598-018-34628-92045-2322https://doaj.org/article/c4e8db67720e4dfeaa7c48284873b70b2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-34628-9https://doaj.org/toc/2045-2322Abstract We aimed to examine whether back pain across adulthood was associated with spine shape at age 60–64 years. Data were from 1405 participants in the MRC National Survey of Health and Development, a nationally representative British birth cohort. Back pain was ascertained during nurse interviews at ages 36, 43, 53 and 60–64 years. Cumulative exposure to back pain was then derived by counting the number of ages at which back pain was reported. Statistical shape modelling was used to characterise thoracolumbar spine shape using lateral dual-energy x-ray absorptiometry images which were ascertained at age 60–64 years. Linear regression models were used to test associations of spine shape modes (SM) with: (1) cumulative exposure to back pain; (2) back pain reports during different periods of adulthood. After adjusting for sex, higher cumulative exposure to back pain across adulthood was associated with wedge-shaped L4-5 disc (lower SM4 scores) and smaller disc spaces (higher SM8 scores) in both sexes. In addition, reporting of back pain at ages 53 and/or 60–64 years was associated with smaller L4-5 disc space (lower SM6 scores) in men but not women. These findings suggest that back pain across adulthood may be associated with specific variations in spine shapes in early old age.Stella G. MuthuriAnastasia V. PavlovaFiona R. SaundersRebecca J. HardyJennifer S. GregoryRebecca J. BarrKathryn R. MartinJudith E. AdamsDiana KuhRichard M. AspdenRachel CooperNature PortfolioarticleSpine ShapeBack Pain ReportsSmall Disk SpaceNational Survey Of Health And Development (NSHD)Statistical Shape Modelling (SSM)MedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Spine Shape Back Pain Reports Small Disk Space National Survey Of Health And Development (NSHD) Statistical Shape Modelling (SSM) Medicine R Science Q
spellingShingle	Spine Shape Back Pain Reports Small Disk Space National Survey Of Health And Development (NSHD) Statistical Shape Modelling (SSM) Medicine R Science Q Stella G. Muthuri Anastasia V. Pavlova Fiona R. Saunders Rebecca J. Hardy Jennifer S. Gregory Rebecca J. Barr Kathryn R. Martin Judith E. Adams Diana Kuh Richard M. Aspden Rachel Cooper Associations between back pain across adulthood and spine shape in early old age in a British birth cohort
description	Abstract We aimed to examine whether back pain across adulthood was associated with spine shape at age 60–64 years. Data were from 1405 participants in the MRC National Survey of Health and Development, a nationally representative British birth cohort. Back pain was ascertained during nurse interviews at ages 36, 43, 53 and 60–64 years. Cumulative exposure to back pain was then derived by counting the number of ages at which back pain was reported. Statistical shape modelling was used to characterise thoracolumbar spine shape using lateral dual-energy x-ray absorptiometry images which were ascertained at age 60–64 years. Linear regression models were used to test associations of spine shape modes (SM) with: (1) cumulative exposure to back pain; (2) back pain reports during different periods of adulthood. After adjusting for sex, higher cumulative exposure to back pain across adulthood was associated with wedge-shaped L4-5 disc (lower SM4 scores) and smaller disc spaces (higher SM8 scores) in both sexes. In addition, reporting of back pain at ages 53 and/or 60–64 years was associated with smaller L4-5 disc space (lower SM6 scores) in men but not women. These findings suggest that back pain across adulthood may be associated with specific variations in spine shapes in early old age.
format	article
author	Stella G. Muthuri Anastasia V. Pavlova Fiona R. Saunders Rebecca J. Hardy Jennifer S. Gregory Rebecca J. Barr Kathryn R. Martin Judith E. Adams Diana Kuh Richard M. Aspden Rachel Cooper
author_facet	Stella G. Muthuri Anastasia V. Pavlova Fiona R. Saunders Rebecca J. Hardy Jennifer S. Gregory Rebecca J. Barr Kathryn R. Martin Judith E. Adams Diana Kuh Richard M. Aspden Rachel Cooper
author_sort	Stella G. Muthuri
title	Associations between back pain across adulthood and spine shape in early old age in a British birth cohort
title_short	Associations between back pain across adulthood and spine shape in early old age in a British birth cohort
title_full	Associations between back pain across adulthood and spine shape in early old age in a British birth cohort
title_fullStr	Associations between back pain across adulthood and spine shape in early old age in a British birth cohort
title_full_unstemmed	Associations between back pain across adulthood and spine shape in early old age in a British birth cohort
title_sort	associations between back pain across adulthood and spine shape in early old age in a british birth cohort
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c4e8db67720e4dfeaa7c48284873b70b
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Associations between back pain across adulthood and spine shape in early old age in a British birth cohort

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