Rapid determination of quaternary protein structures in complex biological samples

Protein structure determination in complex biological samples is still challenging. Here, the authors develop a computational modeling-guided cross-linking mass spectrometry method, obtaining a high-resolution model of a 1.8 MDa protein assembly from cross-links detected in a mixture of human plasma...

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Autores principales:	Simon Hauri, Hamed Khakzad, Lotta Happonen, Johan Teleman, Johan Malmström, Lars Malmström
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c4ea55d53e294d409643497524b1ae3d
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spelling	oai:doaj.org-article:c4ea55d53e294d409643497524b1ae3d2021-12-02T17:01:55ZRapid determination of quaternary protein structures in complex biological samples10.1038/s41467-018-07986-12041-1723https://doaj.org/article/c4ea55d53e294d409643497524b1ae3d2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07986-1https://doaj.org/toc/2041-1723Protein structure determination in complex biological samples is still challenging. Here, the authors develop a computational modeling-guided cross-linking mass spectrometry method, obtaining a high-resolution model of a 1.8 MDa protein assembly from cross-links detected in a mixture of human plasma and bacteria.Simon HauriHamed KhakzadLotta HapponenJohan TelemanJohan MalmströmLars MalmströmNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon Hauri Hamed Khakzad Lotta Happonen Johan Teleman Johan Malmström Lars Malmström Rapid determination of quaternary protein structures in complex biological samples
description	Protein structure determination in complex biological samples is still challenging. Here, the authors develop a computational modeling-guided cross-linking mass spectrometry method, obtaining a high-resolution model of a 1.8 MDa protein assembly from cross-links detected in a mixture of human plasma and bacteria.
format	article
author	Simon Hauri Hamed Khakzad Lotta Happonen Johan Teleman Johan Malmström Lars Malmström
author_facet	Simon Hauri Hamed Khakzad Lotta Happonen Johan Teleman Johan Malmström Lars Malmström
author_sort	Simon Hauri
title	Rapid determination of quaternary protein structures in complex biological samples
title_short	Rapid determination of quaternary protein structures in complex biological samples
title_full	Rapid determination of quaternary protein structures in complex biological samples
title_fullStr	Rapid determination of quaternary protein structures in complex biological samples
title_full_unstemmed	Rapid determination of quaternary protein structures in complex biological samples
title_sort	rapid determination of quaternary protein structures in complex biological samples
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c4ea55d53e294d409643497524b1ae3d
work_keys_str_mv	AT simonhauri rapiddeterminationofquaternaryproteinstructuresincomplexbiologicalsamples AT hamedkhakzad rapiddeterminationofquaternaryproteinstructuresincomplexbiologicalsamples AT lottahapponen rapiddeterminationofquaternaryproteinstructuresincomplexbiologicalsamples AT johanteleman rapiddeterminationofquaternaryproteinstructuresincomplexbiologicalsamples AT johanmalmstrom rapiddeterminationofquaternaryproteinstructuresincomplexbiologicalsamples AT larsmalmstrom rapiddeterminationofquaternaryproteinstructuresincomplexbiologicalsamples
_version_	1718382050234335232

Rapid determination of quaternary protein structures in complex biological samples

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