Rapid determination of quaternary protein structures in complex biological samples

Protein structure determination in complex biological samples is still challenging. Here, the authors develop a computational modeling-guided cross-linking mass spectrometry method, obtaining a high-resolution model of a 1.8 MDa protein assembly from cross-links detected in a mixture of human plasma...

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Autores principales: Simon Hauri, Hamed Khakzad, Lotta Happonen, Johan Teleman, Johan Malmström, Lars Malmström
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/c4ea55d53e294d409643497524b1ae3d
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