Bicuspid aortic valve morphology and aortic valvular outflow jets: an experimental analysis using an MRI-compatible pulsatile flow circulation system

Abstract The characteristics of aortic valvular outflow jet affect aortopathy in the bicuspid aortic valve (BAV). This study aimed to elucidate the effects of BAV morphology on the aortic valvular outflow jets. Morphotype-specific valve-devising apparatuses were developed to create aortic valve mode...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kaoru Hattori, Natsuki Nakama, Jumpei Takada, Gohki Nishimura, Ryo Moriwaki, Eita Kawasaki, Michinobu Nagao, Yasuhiro Goto, Hiroshi Niinami, Kiyotaka Iwasaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c4ebc5b883f64fec95ec4beb63dc8090
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c4ebc5b883f64fec95ec4beb63dc8090
record_format	dspace
spelling	oai:doaj.org-article:c4ebc5b883f64fec95ec4beb63dc80902021-12-02T10:49:23ZBicuspid aortic valve morphology and aortic valvular outflow jets: an experimental analysis using an MRI-compatible pulsatile flow circulation system10.1038/s41598-021-81845-w2045-2322https://doaj.org/article/c4ebc5b883f64fec95ec4beb63dc80902021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81845-whttps://doaj.org/toc/2045-2322Abstract The characteristics of aortic valvular outflow jet affect aortopathy in the bicuspid aortic valve (BAV). This study aimed to elucidate the effects of BAV morphology on the aortic valvular outflow jets. Morphotype-specific valve-devising apparatuses were developed to create aortic valve models. A magnetic resonance imaging-compatible pulsatile flow circulation system was developed to quantify the outflow jet. The eccentricity and circulation values of the peak systolic jet were compared among tricuspid aortic valve (TAV), three asymmetric BAVs, and two symmetric BAVs. The results showed mean aortic flow and leakage did not differ among the five BAVs (six samples, each). Asymmetric BAVs demonstrated the eccentric outflow jets directed to the aortic wall facing the smaller leaflets. In the asymmetric BAV with the smaller leaflet facing the right-anterior, left-posterior, and left-anterior quadrants of the aorta, the outflow jets exclusively impinged on the outer curvature of the ascending aorta, proximal arch, and the supra-valvular aortic wall, respectively. Symmetric BAVs demonstrated mildly eccentric outflow jets that did not impinge on the aortic wall. The circulation values at peak systole increased in asymmetric BAVs. The bicuspid symmetry and the position of smaller leaflet were determinant factors of the characteristics of aortic valvular outflow jet.Kaoru HattoriNatsuki NakamaJumpei TakadaGohki NishimuraRyo MoriwakiEita KawasakiMichinobu NagaoYasuhiro GotoHiroshi NiinamiKiyotaka IwasakiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kaoru Hattori Natsuki Nakama Jumpei Takada Gohki Nishimura Ryo Moriwaki Eita Kawasaki Michinobu Nagao Yasuhiro Goto Hiroshi Niinami Kiyotaka Iwasaki Bicuspid aortic valve morphology and aortic valvular outflow jets: an experimental analysis using an MRI-compatible pulsatile flow circulation system
description	Abstract The characteristics of aortic valvular outflow jet affect aortopathy in the bicuspid aortic valve (BAV). This study aimed to elucidate the effects of BAV morphology on the aortic valvular outflow jets. Morphotype-specific valve-devising apparatuses were developed to create aortic valve models. A magnetic resonance imaging-compatible pulsatile flow circulation system was developed to quantify the outflow jet. The eccentricity and circulation values of the peak systolic jet were compared among tricuspid aortic valve (TAV), three asymmetric BAVs, and two symmetric BAVs. The results showed mean aortic flow and leakage did not differ among the five BAVs (six samples, each). Asymmetric BAVs demonstrated the eccentric outflow jets directed to the aortic wall facing the smaller leaflets. In the asymmetric BAV with the smaller leaflet facing the right-anterior, left-posterior, and left-anterior quadrants of the aorta, the outflow jets exclusively impinged on the outer curvature of the ascending aorta, proximal arch, and the supra-valvular aortic wall, respectively. Symmetric BAVs demonstrated mildly eccentric outflow jets that did not impinge on the aortic wall. The circulation values at peak systole increased in asymmetric BAVs. The bicuspid symmetry and the position of smaller leaflet were determinant factors of the characteristics of aortic valvular outflow jet.
format	article
author	Kaoru Hattori Natsuki Nakama Jumpei Takada Gohki Nishimura Ryo Moriwaki Eita Kawasaki Michinobu Nagao Yasuhiro Goto Hiroshi Niinami Kiyotaka Iwasaki
author_facet	Kaoru Hattori Natsuki Nakama Jumpei Takada Gohki Nishimura Ryo Moriwaki Eita Kawasaki Michinobu Nagao Yasuhiro Goto Hiroshi Niinami Kiyotaka Iwasaki
author_sort	Kaoru Hattori
title	Bicuspid aortic valve morphology and aortic valvular outflow jets: an experimental analysis using an MRI-compatible pulsatile flow circulation system
title_short	Bicuspid aortic valve morphology and aortic valvular outflow jets: an experimental analysis using an MRI-compatible pulsatile flow circulation system
title_full	Bicuspid aortic valve morphology and aortic valvular outflow jets: an experimental analysis using an MRI-compatible pulsatile flow circulation system
title_fullStr	Bicuspid aortic valve morphology and aortic valvular outflow jets: an experimental analysis using an MRI-compatible pulsatile flow circulation system
title_full_unstemmed	Bicuspid aortic valve morphology and aortic valvular outflow jets: an experimental analysis using an MRI-compatible pulsatile flow circulation system
title_sort	bicuspid aortic valve morphology and aortic valvular outflow jets: an experimental analysis using an mri-compatible pulsatile flow circulation system
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c4ebc5b883f64fec95ec4beb63dc8090
work_keys_str_mv	AT kaoruhattori bicuspidaorticvalvemorphologyandaorticvalvularoutflowjetsanexperimentalanalysisusinganmricompatiblepulsatileflowcirculationsystem AT natsukinakama bicuspidaorticvalvemorphologyandaorticvalvularoutflowjetsanexperimentalanalysisusinganmricompatiblepulsatileflowcirculationsystem AT jumpeitakada bicuspidaorticvalvemorphologyandaorticvalvularoutflowjetsanexperimentalanalysisusinganmricompatiblepulsatileflowcirculationsystem AT gohkinishimura bicuspidaorticvalvemorphologyandaorticvalvularoutflowjetsanexperimentalanalysisusinganmricompatiblepulsatileflowcirculationsystem AT ryomoriwaki bicuspidaorticvalvemorphologyandaorticvalvularoutflowjetsanexperimentalanalysisusinganmricompatiblepulsatileflowcirculationsystem AT eitakawasaki bicuspidaorticvalvemorphologyandaorticvalvularoutflowjetsanexperimentalanalysisusinganmricompatiblepulsatileflowcirculationsystem AT michinobunagao bicuspidaorticvalvemorphologyandaorticvalvularoutflowjetsanexperimentalanalysisusinganmricompatiblepulsatileflowcirculationsystem AT yasuhirogoto bicuspidaorticvalvemorphologyandaorticvalvularoutflowjetsanexperimentalanalysisusinganmricompatiblepulsatileflowcirculationsystem AT hiroshiniinami bicuspidaorticvalvemorphologyandaorticvalvularoutflowjetsanexperimentalanalysisusinganmricompatiblepulsatileflowcirculationsystem AT kiyotakaiwasaki bicuspidaorticvalvemorphologyandaorticvalvularoutflowjetsanexperimentalanalysisusinganmricompatiblepulsatileflowcirculationsystem
_version_	1718396616342241280

Bicuspid aortic valve morphology and aortic valvular outflow jets: an experimental analysis using an MRI-compatible pulsatile flow circulation system

Ejemplares similares