Dynamics of replication origin over-activation

DNA replication processes are often dysregulated in cancer. Here the authors analyse DNA synthesis patterns in cancer cells undergoing partial genome re-replication to reveal that re-replication exhibits aberrant replication fork dynamics and a skewed distribution of replication initiation that over...

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Autores principales:	Haiqing Fu, Christophe E. Redon, Bhushan L. Thakur, Koichi Utani, Robin Sebastian, Sang-Min Jang, Jacob M. Gross, Sara Mosavarpour, Anna B. Marks, Sophie Z. Zhuang, Sarah B. Lazar, Mishal Rao, Shira T. Mencer, Adrian M. Baris, Lorinc S. Pongor, Mirit I. Aladjem
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c4f21954d04b40579b7e5e71d863a0a4
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spelling	oai:doaj.org-article:c4f21954d04b40579b7e5e71d863a0a42021-12-02T17:30:38ZDynamics of replication origin over-activation10.1038/s41467-021-23835-02041-1723https://doaj.org/article/c4f21954d04b40579b7e5e71d863a0a42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23835-0https://doaj.org/toc/2041-1723DNA replication processes are often dysregulated in cancer. Here the authors analyse DNA synthesis patterns in cancer cells undergoing partial genome re-replication to reveal that re-replication exhibits aberrant replication fork dynamics and a skewed distribution of replication initiation that over-duplicates early-replicating genomic regions.Haiqing FuChristophe E. RedonBhushan L. ThakurKoichi UtaniRobin SebastianSang-Min JangJacob M. GrossSara MosavarpourAnna B. MarksSophie Z. ZhuangSarah B. LazarMishal RaoShira T. MencerAdrian M. BarisLorinc S. PongorMirit I. AladjemNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haiqing Fu Christophe E. Redon Bhushan L. Thakur Koichi Utani Robin Sebastian Sang-Min Jang Jacob M. Gross Sara Mosavarpour Anna B. Marks Sophie Z. Zhuang Sarah B. Lazar Mishal Rao Shira T. Mencer Adrian M. Baris Lorinc S. Pongor Mirit I. Aladjem Dynamics of replication origin over-activation
description	DNA replication processes are often dysregulated in cancer. Here the authors analyse DNA synthesis patterns in cancer cells undergoing partial genome re-replication to reveal that re-replication exhibits aberrant replication fork dynamics and a skewed distribution of replication initiation that over-duplicates early-replicating genomic regions.
format	article
author	Haiqing Fu Christophe E. Redon Bhushan L. Thakur Koichi Utani Robin Sebastian Sang-Min Jang Jacob M. Gross Sara Mosavarpour Anna B. Marks Sophie Z. Zhuang Sarah B. Lazar Mishal Rao Shira T. Mencer Adrian M. Baris Lorinc S. Pongor Mirit I. Aladjem
author_facet	Haiqing Fu Christophe E. Redon Bhushan L. Thakur Koichi Utani Robin Sebastian Sang-Min Jang Jacob M. Gross Sara Mosavarpour Anna B. Marks Sophie Z. Zhuang Sarah B. Lazar Mishal Rao Shira T. Mencer Adrian M. Baris Lorinc S. Pongor Mirit I. Aladjem
author_sort	Haiqing Fu
title	Dynamics of replication origin over-activation
title_short	Dynamics of replication origin over-activation
title_full	Dynamics of replication origin over-activation
title_fullStr	Dynamics of replication origin over-activation
title_full_unstemmed	Dynamics of replication origin over-activation
title_sort	dynamics of replication origin over-activation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c4f21954d04b40579b7e5e71d863a0a4
work_keys_str_mv	AT haiqingfu dynamicsofreplicationoriginoveractivation AT christopheeredon dynamicsofreplicationoriginoveractivation AT bhushanlthakur dynamicsofreplicationoriginoveractivation AT koichiutani dynamicsofreplicationoriginoveractivation AT robinsebastian dynamicsofreplicationoriginoveractivation AT sangminjang dynamicsofreplicationoriginoveractivation AT jacobmgross dynamicsofreplicationoriginoveractivation AT saramosavarpour dynamicsofreplicationoriginoveractivation AT annabmarks dynamicsofreplicationoriginoveractivation AT sophiezzhuang dynamicsofreplicationoriginoveractivation AT sarahblazar dynamicsofreplicationoriginoveractivation AT mishalrao dynamicsofreplicationoriginoveractivation AT shiratmencer dynamicsofreplicationoriginoveractivation AT adrianmbaris dynamicsofreplicationoriginoveractivation AT lorincspongor dynamicsofreplicationoriginoveractivation AT miritialadjem dynamicsofreplicationoriginoveractivation
_version_	1718380753266409472

Dynamics of replication origin over-activation

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