Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction

Population structure, even subtle differences within seemingly homogenous populations, can have an impact on the accuracy of polygenic prediction. Here, Sakaue et al. use dimensionality reduction methods to reveal fine-scale structure in the Biobank Japan cohort and explore the performance of polyge...

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Autores principales:	Saori Sakaue, Jun Hirata, Masahiro Kanai, Ken Suzuki, Masato Akiyama, Chun Lai Too, Thurayya Arayssi, Mohammed Hammoudeh, Samar Al Emadi, Basel K. Masri, Hussein Halabi, Humeira Badsha, Imad W. Uthman, Richa Saxena, Leonid Padyukov, Makoto Hirata, Koichi Matsuda, Yoshinori Murakami, Yoichiro Kamatani, Yukinori Okada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c4f4b797ca974d86bfaca12d2007301f
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spelling	oai:doaj.org-article:c4f4b797ca974d86bfaca12d2007301f2021-12-02T16:49:28ZDimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction10.1038/s41467-020-15194-z2041-1723https://doaj.org/article/c4f4b797ca974d86bfaca12d2007301f2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15194-zhttps://doaj.org/toc/2041-1723Population structure, even subtle differences within seemingly homogenous populations, can have an impact on the accuracy of polygenic prediction. Here, Sakaue et al. use dimensionality reduction methods to reveal fine-scale structure in the Biobank Japan cohort and explore the performance of polygenic risk scores.Saori SakaueJun HirataMasahiro KanaiKen SuzukiMasato AkiyamaChun Lai TooThurayya ArayssiMohammed HammoudehSamar Al EmadiBasel K. MasriHussein HalabiHumeira BadshaImad W. UthmanRicha SaxenaLeonid PadyukovMakoto HirataKoichi MatsudaYoshinori MurakamiYoichiro KamataniYukinori OkadaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Saori Sakaue Jun Hirata Masahiro Kanai Ken Suzuki Masato Akiyama Chun Lai Too Thurayya Arayssi Mohammed Hammoudeh Samar Al Emadi Basel K. Masri Hussein Halabi Humeira Badsha Imad W. Uthman Richa Saxena Leonid Padyukov Makoto Hirata Koichi Matsuda Yoshinori Murakami Yoichiro Kamatani Yukinori Okada Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction
description	Population structure, even subtle differences within seemingly homogenous populations, can have an impact on the accuracy of polygenic prediction. Here, Sakaue et al. use dimensionality reduction methods to reveal fine-scale structure in the Biobank Japan cohort and explore the performance of polygenic risk scores.
format	article
author	Saori Sakaue Jun Hirata Masahiro Kanai Ken Suzuki Masato Akiyama Chun Lai Too Thurayya Arayssi Mohammed Hammoudeh Samar Al Emadi Basel K. Masri Hussein Halabi Humeira Badsha Imad W. Uthman Richa Saxena Leonid Padyukov Makoto Hirata Koichi Matsuda Yoshinori Murakami Yoichiro Kamatani Yukinori Okada
author_facet	Saori Sakaue Jun Hirata Masahiro Kanai Ken Suzuki Masato Akiyama Chun Lai Too Thurayya Arayssi Mohammed Hammoudeh Samar Al Emadi Basel K. Masri Hussein Halabi Humeira Badsha Imad W. Uthman Richa Saxena Leonid Padyukov Makoto Hirata Koichi Matsuda Yoshinori Murakami Yoichiro Kamatani Yukinori Okada
author_sort	Saori Sakaue
title	Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction
title_short	Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction
title_full	Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction
title_fullStr	Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction
title_full_unstemmed	Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction
title_sort	dimensionality reduction reveals fine-scale structure in the japanese population with consequences for polygenic risk prediction
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c4f4b797ca974d86bfaca12d2007301f
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Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction

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