Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia

Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia

Acute Myeloid Leukemia (AML) develops following multiple mutations of differing impact. Here, the authors show that activating mutations of CSF3R co-operate with loss-of-function mutations of CEBPA to promote AML development through an enhancer-dependent mechanism.

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Autores principales: Theodore P. Braun, Mariam Okhovat, Cody Coblentz, Sarah A. Carratt, Amy Foley, Zachary Schonrock, Brittany M. Smith, Kimberly Nevonen, Brett Davis, Brianna Garcia, Dorian LaTocha, Benjamin R. Weeder, Michal R. Grzadkowski, Joey C. Estabrook, Hannah G. Manning, Kevin Watanabe-Smith, Sophia Jeng, Jenny L. Smith, Amanda R. Leonti, Rhonda E. Ries, Shannon McWeeney, Cristina Di Genua, Roy Drissen, Claus Nerlov, Soheil Meshinchi, Lucia Carbone, Brian J. Druker, Julia E. Maxson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/c4f5920cda714e2080bbc04d4c0c3d87
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spelling oai:doaj.org-article:c4f5920cda714e2080bbc04d4c0c3d872021-12-02T16:57:55ZMyeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia10.1038/s41467-019-13364-22041-1723https://doaj.org/article/c4f5920cda714e2080bbc04d4c0c3d872019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13364-2https://doaj.org/toc/2041-1723Acute Myeloid Leukemia (AML) develops following multiple mutations of differing impact. Here, the authors show that activating mutations of CSF3R co-operate with loss-of-function mutations of CEBPA to promote AML development through an enhancer-dependent mechanism.Theodore P. BraunMariam OkhovatCody CoblentzSarah A. CarrattAmy FoleyZachary SchonrockBrittany M. SmithKimberly NevonenBrett DavisBrianna GarciaDorian LaTochaBenjamin R. WeederMichal R. GrzadkowskiJoey C. EstabrookHannah G. ManningKevin Watanabe-SmithSophia JengJenny L. SmithAmanda R. LeontiRhonda E. RiesShannon McWeeneyCristina Di GenuaRoy DrissenClaus NerlovSoheil MeshinchiLucia CarboneBrian J. DrukerJulia E. MaxsonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Theodore P. Braun
Mariam Okhovat
Cody Coblentz
Sarah A. Carratt
Amy Foley
Zachary Schonrock
Brittany M. Smith
Kimberly Nevonen
Brett Davis
Brianna Garcia
Dorian LaTocha
Benjamin R. Weeder
Michal R. Grzadkowski
Joey C. Estabrook
Hannah G. Manning
Kevin Watanabe-Smith
Sophia Jeng
Jenny L. Smith
Amanda R. Leonti
Rhonda E. Ries
Shannon McWeeney
Cristina Di Genua
Roy Drissen
Claus Nerlov
Soheil Meshinchi
Lucia Carbone
Brian J. Druker
Julia E. Maxson
Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia
description Acute Myeloid Leukemia (AML) develops following multiple mutations of differing impact. Here, the authors show that activating mutations of CSF3R co-operate with loss-of-function mutations of CEBPA to promote AML development through an enhancer-dependent mechanism.
format article
author Theodore P. Braun
Mariam Okhovat
Cody Coblentz
Sarah A. Carratt
Amy Foley
Zachary Schonrock
Brittany M. Smith
Kimberly Nevonen
Brett Davis
Brianna Garcia
Dorian LaTocha
Benjamin R. Weeder
Michal R. Grzadkowski
Joey C. Estabrook
Hannah G. Manning
Kevin Watanabe-Smith
Sophia Jeng
Jenny L. Smith
Amanda R. Leonti
Rhonda E. Ries
Shannon McWeeney
Cristina Di Genua
Roy Drissen
Claus Nerlov
Soheil Meshinchi
Lucia Carbone
Brian J. Druker
Julia E. Maxson
author_facet Theodore P. Braun
Mariam Okhovat
Cody Coblentz
Sarah A. Carratt
Amy Foley
Zachary Schonrock
Brittany M. Smith
Kimberly Nevonen
Brett Davis
Brianna Garcia
Dorian LaTocha
Benjamin R. Weeder
Michal R. Grzadkowski
Joey C. Estabrook
Hannah G. Manning
Kevin Watanabe-Smith
Sophia Jeng
Jenny L. Smith
Amanda R. Leonti
Rhonda E. Ries
Shannon McWeeney
Cristina Di Genua
Roy Drissen
Claus Nerlov
Soheil Meshinchi
Lucia Carbone
Brian J. Druker
Julia E. Maxson
author_sort Theodore P. Braun
title Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia
title_short Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia
title_full Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia
title_fullStr Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia
title_full_unstemmed Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia
title_sort myeloid lineage enhancers drive oncogene synergy in cebpa/csf3r mutant acute myeloid leukemia
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/c4f5920cda714e2080bbc04d4c0c3d87
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