Mechanosensitive channel YnaI has lipid-bound extended sensor paddles
Hu, Wang & Zheng describe the cryo-EM structure of a bacterial MscS-like channel, named YnaI, in closed state. They further describe its extended paddle domain that is attached to the N-terminus of MscS, lipid pockets between paddles, its ion-conducting pathway, and its heptameric assembly, fina...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/c4f83f029ffe4e5a80ba716cb0c6ead4 |
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| Sumario: | Hu, Wang & Zheng describe the cryo-EM structure of a bacterial MscS-like channel, named YnaI, in closed state. They further describe its extended paddle domain that is attached to the N-terminus of MscS, lipid pockets between paddles, its ion-conducting pathway, and its heptameric assembly, finally discussing its mechanosensing mechanism. |
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