Mechanosensitive channel YnaI has lipid-bound extended sensor paddles

Hu, Wang & Zheng describe the cryo-EM structure of a bacterial MscS-like channel, named YnaI, in closed state. They further describe its extended paddle domain that is attached to the N-terminus of MscS, lipid pockets between paddles, its ion-conducting pathway, and its heptameric assembly, fina...

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Autores principales: Wenxin Hu, Zhiming Wang, Hongjin Zheng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c4f83f029ffe4e5a80ba716cb0c6ead4
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spelling oai:doaj.org-article:c4f83f029ffe4e5a80ba716cb0c6ead42021-12-02T16:49:37ZMechanosensitive channel YnaI has lipid-bound extended sensor paddles10.1038/s42003-021-02122-02399-3642https://doaj.org/article/c4f83f029ffe4e5a80ba716cb0c6ead42021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02122-0https://doaj.org/toc/2399-3642Hu, Wang & Zheng describe the cryo-EM structure of a bacterial MscS-like channel, named YnaI, in closed state. They further describe its extended paddle domain that is attached to the N-terminus of MscS, lipid pockets between paddles, its ion-conducting pathway, and its heptameric assembly, finally discussing its mechanosensing mechanism.Wenxin HuZhiming WangHongjin ZhengNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Wenxin Hu
Zhiming Wang
Hongjin Zheng
Mechanosensitive channel YnaI has lipid-bound extended sensor paddles
description Hu, Wang & Zheng describe the cryo-EM structure of a bacterial MscS-like channel, named YnaI, in closed state. They further describe its extended paddle domain that is attached to the N-terminus of MscS, lipid pockets between paddles, its ion-conducting pathway, and its heptameric assembly, finally discussing its mechanosensing mechanism.
format article
author Wenxin Hu
Zhiming Wang
Hongjin Zheng
author_facet Wenxin Hu
Zhiming Wang
Hongjin Zheng
author_sort Wenxin Hu
title Mechanosensitive channel YnaI has lipid-bound extended sensor paddles
title_short Mechanosensitive channel YnaI has lipid-bound extended sensor paddles
title_full Mechanosensitive channel YnaI has lipid-bound extended sensor paddles
title_fullStr Mechanosensitive channel YnaI has lipid-bound extended sensor paddles
title_full_unstemmed Mechanosensitive channel YnaI has lipid-bound extended sensor paddles
title_sort mechanosensitive channel ynai has lipid-bound extended sensor paddles
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c4f83f029ffe4e5a80ba716cb0c6ead4
work_keys_str_mv AT wenxinhu mechanosensitivechannelynaihaslipidboundextendedsensorpaddles
AT zhimingwang mechanosensitivechannelynaihaslipidboundextendedsensorpaddles
AT hongjinzheng mechanosensitivechannelynaihaslipidboundextendedsensorpaddles
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