Increased risk of serious non-AIDS-related events in HIV-infected subjects on antiretroviral therapy associated with a low CD4/CD8 ratio.

<h4>Background</h4>A low CD4/CD8 ratio has been identified in the general population as a hallmark of inmmunosenescence and a surrogate of all-cause mortality. We aimed to investigate in treated HIV-infected individuals the relationship between the CD4/CD8 ratio and serious non-AIDS even...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sergio Serrano-Villar, María Jesús Pérez-Elías, Fernando Dronda, José Luis Casado, Ana Moreno, Ana Royuela, José Antonio Pérez-Molina, Talia Sainz, Enrique Navas, José Manuel Hermida, Carmen Quereda, Santiago Moreno
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c4f8d710629644a0a88619a740c0cbda
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c4f8d710629644a0a88619a740c0cbda
record_format	dspace
spelling	oai:doaj.org-article:c4f8d710629644a0a88619a740c0cbda2021-11-18T08:34:54ZIncreased risk of serious non-AIDS-related events in HIV-infected subjects on antiretroviral therapy associated with a low CD4/CD8 ratio.1932-620310.1371/journal.pone.0085798https://doaj.org/article/c4f8d710629644a0a88619a740c0cbda2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24497929/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>A low CD4/CD8 ratio has been identified in the general population as a hallmark of inmmunosenescence and a surrogate of all-cause mortality. We aimed to investigate in treated HIV-infected individuals the relationship between the CD4/CD8 ratio and serious non-AIDS events.<h4>Methods</h4>Case-control study within a prospective hospital-based cohort of HIV-infected subjects during at least one year of ART-mediated viral suppression. Cases were patients with serious non-AIDS events (non-AIDS malignancies, cardiovascular disease, and end-stage kidney disease), and controls individuals who did not developed non-AIDS events during follow-up. Data were analyzed using ROC analysis and multivariate logistic regression. Conditional logistic regression was performed in 200 cases/controls matched by age, sex, nadir CD4 and proximal CD4 counts.<h4>Results</h4>We analyzed 407 subjects (109 cases, 298 controls). The CD4/CD8 ratio was lower in cases (0.44 vs. 0.70, P<0.0001), with higher discriminatory ability for the detection of non-AIDS events than the CD4 count, CD8 count and nadir CD4. Multivariate analyses (adjusted for age, sex, nadir CD4, proximal CD4 count, year of ART initiation and ART duration) confirmed the independent association of a low CD4/CD8 ratio with the risk of non-AIDS morbidity (per CD4/CD8 ratio quartile decrease, OR, 2.9; 95% CI, 1.3-6.2) and non-AIDS mortality (OR, 2.8; 95% CI, 1.5-5.3).<h4>Conclusions</h4>The CD4/CD8 ratio provides additional information to the CD4 counts and nadir CD4 in treated HIV-infected individuals, since it is independently associated with the risk of non-AIDS-related morbidity and mortality. This association is robust and maintained within different subgroups of patients.Sergio Serrano-VillarMaría Jesús Pérez-ElíasFernando DrondaJosé Luis CasadoAna MorenoAna RoyuelaJosé Antonio Pérez-MolinaTalia SainzEnrique NavasJosé Manuel HermidaCarmen QueredaSantiago MorenoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e85798 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sergio Serrano-Villar María Jesús Pérez-Elías Fernando Dronda José Luis Casado Ana Moreno Ana Royuela José Antonio Pérez-Molina Talia Sainz Enrique Navas José Manuel Hermida Carmen Quereda Santiago Moreno Increased risk of serious non-AIDS-related events in HIV-infected subjects on antiretroviral therapy associated with a low CD4/CD8 ratio.
description	<h4>Background</h4>A low CD4/CD8 ratio has been identified in the general population as a hallmark of inmmunosenescence and a surrogate of all-cause mortality. We aimed to investigate in treated HIV-infected individuals the relationship between the CD4/CD8 ratio and serious non-AIDS events.<h4>Methods</h4>Case-control study within a prospective hospital-based cohort of HIV-infected subjects during at least one year of ART-mediated viral suppression. Cases were patients with serious non-AIDS events (non-AIDS malignancies, cardiovascular disease, and end-stage kidney disease), and controls individuals who did not developed non-AIDS events during follow-up. Data were analyzed using ROC analysis and multivariate logistic regression. Conditional logistic regression was performed in 200 cases/controls matched by age, sex, nadir CD4 and proximal CD4 counts.<h4>Results</h4>We analyzed 407 subjects (109 cases, 298 controls). The CD4/CD8 ratio was lower in cases (0.44 vs. 0.70, P<0.0001), with higher discriminatory ability for the detection of non-AIDS events than the CD4 count, CD8 count and nadir CD4. Multivariate analyses (adjusted for age, sex, nadir CD4, proximal CD4 count, year of ART initiation and ART duration) confirmed the independent association of a low CD4/CD8 ratio with the risk of non-AIDS morbidity (per CD4/CD8 ratio quartile decrease, OR, 2.9; 95% CI, 1.3-6.2) and non-AIDS mortality (OR, 2.8; 95% CI, 1.5-5.3).<h4>Conclusions</h4>The CD4/CD8 ratio provides additional information to the CD4 counts and nadir CD4 in treated HIV-infected individuals, since it is independently associated with the risk of non-AIDS-related morbidity and mortality. This association is robust and maintained within different subgroups of patients.
format	article
author	Sergio Serrano-Villar María Jesús Pérez-Elías Fernando Dronda José Luis Casado Ana Moreno Ana Royuela José Antonio Pérez-Molina Talia Sainz Enrique Navas José Manuel Hermida Carmen Quereda Santiago Moreno
author_facet	Sergio Serrano-Villar María Jesús Pérez-Elías Fernando Dronda José Luis Casado Ana Moreno Ana Royuela José Antonio Pérez-Molina Talia Sainz Enrique Navas José Manuel Hermida Carmen Quereda Santiago Moreno
author_sort	Sergio Serrano-Villar
title	Increased risk of serious non-AIDS-related events in HIV-infected subjects on antiretroviral therapy associated with a low CD4/CD8 ratio.
title_short	Increased risk of serious non-AIDS-related events in HIV-infected subjects on antiretroviral therapy associated with a low CD4/CD8 ratio.
title_full	Increased risk of serious non-AIDS-related events in HIV-infected subjects on antiretroviral therapy associated with a low CD4/CD8 ratio.
title_fullStr	Increased risk of serious non-AIDS-related events in HIV-infected subjects on antiretroviral therapy associated with a low CD4/CD8 ratio.
title_full_unstemmed	Increased risk of serious non-AIDS-related events in HIV-infected subjects on antiretroviral therapy associated with a low CD4/CD8 ratio.
title_sort	increased risk of serious non-aids-related events in hiv-infected subjects on antiretroviral therapy associated with a low cd4/cd8 ratio.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/c4f8d710629644a0a88619a740c0cbda
work_keys_str_mv	AT sergioserranovillar increasedriskofseriousnonaidsrelatedeventsinhivinfectedsubjectsonantiretroviraltherapyassociatedwithalowcd4cd8ratio AT mariajesusperezelias increasedriskofseriousnonaidsrelatedeventsinhivinfectedsubjectsonantiretroviraltherapyassociatedwithalowcd4cd8ratio AT fernandodronda increasedriskofseriousnonaidsrelatedeventsinhivinfectedsubjectsonantiretroviraltherapyassociatedwithalowcd4cd8ratio AT joseluiscasado increasedriskofseriousnonaidsrelatedeventsinhivinfectedsubjectsonantiretroviraltherapyassociatedwithalowcd4cd8ratio AT anamoreno increasedriskofseriousnonaidsrelatedeventsinhivinfectedsubjectsonantiretroviraltherapyassociatedwithalowcd4cd8ratio AT anaroyuela increasedriskofseriousnonaidsrelatedeventsinhivinfectedsubjectsonantiretroviraltherapyassociatedwithalowcd4cd8ratio AT joseantonioperezmolina increasedriskofseriousnonaidsrelatedeventsinhivinfectedsubjectsonantiretroviraltherapyassociatedwithalowcd4cd8ratio AT taliasainz increasedriskofseriousnonaidsrelatedeventsinhivinfectedsubjectsonantiretroviraltherapyassociatedwithalowcd4cd8ratio AT enriquenavas increasedriskofseriousnonaidsrelatedeventsinhivinfectedsubjectsonantiretroviraltherapyassociatedwithalowcd4cd8ratio AT josemanuelhermida increasedriskofseriousnonaidsrelatedeventsinhivinfectedsubjectsonantiretroviraltherapyassociatedwithalowcd4cd8ratio AT carmenquereda increasedriskofseriousnonaidsrelatedeventsinhivinfectedsubjectsonantiretroviraltherapyassociatedwithalowcd4cd8ratio AT santiagomoreno increasedriskofseriousnonaidsrelatedeventsinhivinfectedsubjectsonantiretroviraltherapyassociatedwithalowcd4cd8ratio
_version_	1718421646530838528

Increased risk of serious non-AIDS-related events in HIV-infected subjects on antiretroviral therapy associated with a low CD4/CD8 ratio.

Ejemplares similares