Characterization of sex determination and sex differentiation genes in Latimeria.
Genes involved in sex determination and differentiation have been identified in mice, humans, chickens, reptiles, amphibians and teleost fishes. However, little is known of their functional conservation, and it is unclear whether there is a common set of genes shared by all vertebrates. Coelacanths,...
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2013
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oai:doaj.org-article:c4f9b74690cf4397850fbbaf4a0c91d42021-11-18T07:47:54ZCharacterization of sex determination and sex differentiation genes in Latimeria.1932-620310.1371/journal.pone.0056006https://doaj.org/article/c4f9b74690cf4397850fbbaf4a0c91d42013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23634199/?tool=EBIhttps://doaj.org/toc/1932-6203Genes involved in sex determination and differentiation have been identified in mice, humans, chickens, reptiles, amphibians and teleost fishes. However, little is known of their functional conservation, and it is unclear whether there is a common set of genes shared by all vertebrates. Coelacanths, basal Sarcopterygians and unique "living fossils", could help establish an inventory of the ancestral genes involved in these important developmental processes and provide insights into their components. In this study 33 genes from the genome of Latimeria chalumnae and from the liver and testis transcriptomes of Latimeria menadoensis, implicated in sex determination and differentiation, were identified and characterized and their expression levels measured. Interesting findings were obtained for GSDF, previously identified only in teleosts and now characterized for the first time in the sarcopterygian lineage; FGF9, which is not found in teleosts; and DMRT1, whose expression in adult gonads has recently been related to maintenance of sexual identity. The gene repertoire and testis-specific gene expression documented in coelacanths demonstrate a greater similarity to modern fishes and point to unexpected changes in the gene regulatory network governing sexual development.Mariko ForconiAdriana CanapaMarco BaruccaMaria A BiscottiTeresa CapriglioneFrancesco BuonocoreAnna M FaustoDaisy M MakapeduaAlberto PallaviciniMarco GerdolGianluca De MoroGiuseppe ScapigliatiEttore OlmoManfred SchartlPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e56006 (2013) |
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DOAJ |
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| topic |
Medicine R Science Q |
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Medicine R Science Q Mariko Forconi Adriana Canapa Marco Barucca Maria A Biscotti Teresa Capriglione Francesco Buonocore Anna M Fausto Daisy M Makapedua Alberto Pallavicini Marco Gerdol Gianluca De Moro Giuseppe Scapigliati Ettore Olmo Manfred Schartl Characterization of sex determination and sex differentiation genes in Latimeria. |
| description |
Genes involved in sex determination and differentiation have been identified in mice, humans, chickens, reptiles, amphibians and teleost fishes. However, little is known of their functional conservation, and it is unclear whether there is a common set of genes shared by all vertebrates. Coelacanths, basal Sarcopterygians and unique "living fossils", could help establish an inventory of the ancestral genes involved in these important developmental processes and provide insights into their components. In this study 33 genes from the genome of Latimeria chalumnae and from the liver and testis transcriptomes of Latimeria menadoensis, implicated in sex determination and differentiation, were identified and characterized and their expression levels measured. Interesting findings were obtained for GSDF, previously identified only in teleosts and now characterized for the first time in the sarcopterygian lineage; FGF9, which is not found in teleosts; and DMRT1, whose expression in adult gonads has recently been related to maintenance of sexual identity. The gene repertoire and testis-specific gene expression documented in coelacanths demonstrate a greater similarity to modern fishes and point to unexpected changes in the gene regulatory network governing sexual development. |
| format |
article |
| author |
Mariko Forconi Adriana Canapa Marco Barucca Maria A Biscotti Teresa Capriglione Francesco Buonocore Anna M Fausto Daisy M Makapedua Alberto Pallavicini Marco Gerdol Gianluca De Moro Giuseppe Scapigliati Ettore Olmo Manfred Schartl |
| author_facet |
Mariko Forconi Adriana Canapa Marco Barucca Maria A Biscotti Teresa Capriglione Francesco Buonocore Anna M Fausto Daisy M Makapedua Alberto Pallavicini Marco Gerdol Gianluca De Moro Giuseppe Scapigliati Ettore Olmo Manfred Schartl |
| author_sort |
Mariko Forconi |
| title |
Characterization of sex determination and sex differentiation genes in Latimeria. |
| title_short |
Characterization of sex determination and sex differentiation genes in Latimeria. |
| title_full |
Characterization of sex determination and sex differentiation genes in Latimeria. |
| title_fullStr |
Characterization of sex determination and sex differentiation genes in Latimeria. |
| title_full_unstemmed |
Characterization of sex determination and sex differentiation genes in Latimeria. |
| title_sort |
characterization of sex determination and sex differentiation genes in latimeria. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/c4f9b74690cf4397850fbbaf4a0c91d4 |
| work_keys_str_mv |
AT marikoforconi characterizationofsexdeterminationandsexdifferentiationgenesinlatimeria AT adrianacanapa characterizationofsexdeterminationandsexdifferentiationgenesinlatimeria AT marcobarucca characterizationofsexdeterminationandsexdifferentiationgenesinlatimeria AT mariaabiscotti characterizationofsexdeterminationandsexdifferentiationgenesinlatimeria AT teresacapriglione characterizationofsexdeterminationandsexdifferentiationgenesinlatimeria AT francescobuonocore characterizationofsexdeterminationandsexdifferentiationgenesinlatimeria AT annamfausto characterizationofsexdeterminationandsexdifferentiationgenesinlatimeria AT daisymmakapedua characterizationofsexdeterminationandsexdifferentiationgenesinlatimeria AT albertopallavicini characterizationofsexdeterminationandsexdifferentiationgenesinlatimeria AT marcogerdol characterizationofsexdeterminationandsexdifferentiationgenesinlatimeria AT gianlucademoro characterizationofsexdeterminationandsexdifferentiationgenesinlatimeria AT giuseppescapigliati characterizationofsexdeterminationandsexdifferentiationgenesinlatimeria AT ettoreolmo characterizationofsexdeterminationandsexdifferentiationgenesinlatimeria AT manfredschartl characterizationofsexdeterminationandsexdifferentiationgenesinlatimeria |
| _version_ |
1718422936075894784 |