Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia

The Wnt pathway is one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL) and is activated in only a subset of patients; however, no universal drivers of the disease have been identified. Here the authors show that Notch2 and β-catenin pathways are the main drivers of the pro-s...

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Autores principales:	Maurizio Mangolini, Frederik Götte, Andrew Moore, Tim Ammon, Madlen Oelsner, Gloria Lutzny-Geier, Ludger Klein-Hitpass, James C. Williamson, Paul J. Lehner, Jan Dürig, Michael Möllmann, Lívia Rásó-Barnett, Katherine Hughes, Antonella Santoro, Simón Méndez-Ferrer, Robert A. J. Oostendorp, Ursula Zimber-Strobl, Christian Peschel, Daniel J. Hodson, Marc Schmidt-Supprian, Ingo Ringshausen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c4f9c099f3104cabbf026773512a17d1
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spelling	oai:doaj.org-article:c4f9c099f3104cabbf026773512a17d12021-12-02T15:34:22ZNotch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia10.1038/s41467-018-06069-52041-1723https://doaj.org/article/c4f9c099f3104cabbf026773512a17d12018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06069-5https://doaj.org/toc/2041-1723The Wnt pathway is one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL) and is activated in only a subset of patients; however, no universal drivers of the disease have been identified. Here the authors show that Notch2 and β-catenin pathways are the main drivers of the pro-survival bidirectional crosstalk between stromal cells and leukemic cells.Maurizio MangoliniFrederik GötteAndrew MooreTim AmmonMadlen OelsnerGloria Lutzny-GeierLudger Klein-HitpassJames C. WilliamsonPaul J. LehnerJan DürigMichael MöllmannLívia Rásó-BarnettKatherine HughesAntonella SantoroSimón Méndez-FerrerRobert A. J. OostendorpUrsula Zimber-StroblChristian PeschelDaniel J. HodsonMarc Schmidt-SupprianIngo RingshausenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maurizio Mangolini Frederik Götte Andrew Moore Tim Ammon Madlen Oelsner Gloria Lutzny-Geier Ludger Klein-Hitpass James C. Williamson Paul J. Lehner Jan Dürig Michael Möllmann Lívia Rásó-Barnett Katherine Hughes Antonella Santoro Simón Méndez-Ferrer Robert A. J. Oostendorp Ursula Zimber-Strobl Christian Peschel Daniel J. Hodson Marc Schmidt-Supprian Ingo Ringshausen Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia
description	The Wnt pathway is one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL) and is activated in only a subset of patients; however, no universal drivers of the disease have been identified. Here the authors show that Notch2 and β-catenin pathways are the main drivers of the pro-survival bidirectional crosstalk between stromal cells and leukemic cells.
format	article
author	Maurizio Mangolini Frederik Götte Andrew Moore Tim Ammon Madlen Oelsner Gloria Lutzny-Geier Ludger Klein-Hitpass James C. Williamson Paul J. Lehner Jan Dürig Michael Möllmann Lívia Rásó-Barnett Katherine Hughes Antonella Santoro Simón Méndez-Ferrer Robert A. J. Oostendorp Ursula Zimber-Strobl Christian Peschel Daniel J. Hodson Marc Schmidt-Supprian Ingo Ringshausen
author_facet	Maurizio Mangolini Frederik Götte Andrew Moore Tim Ammon Madlen Oelsner Gloria Lutzny-Geier Ludger Klein-Hitpass James C. Williamson Paul J. Lehner Jan Dürig Michael Möllmann Lívia Rásó-Barnett Katherine Hughes Antonella Santoro Simón Méndez-Ferrer Robert A. J. Oostendorp Ursula Zimber-Strobl Christian Peschel Daniel J. Hodson Marc Schmidt-Supprian Ingo Ringshausen
author_sort	Maurizio Mangolini
title	Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia
title_short	Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia
title_full	Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia
title_fullStr	Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia
title_full_unstemmed	Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia
title_sort	notch2 controls non-autonomous wnt-signalling in chronic lymphocytic leukaemia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c4f9c099f3104cabbf026773512a17d1
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Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia

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