CYTOKINE CONTENTS IN NASAL SECRETIONS OF CHILDREN WITH COMBINED FORMS OF RESPIRATORY POLLEN ALLERGY BEFORE AND AFTER THREE COURSES OF SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY

We studied clinical efficacy of sublingual immunotherapy in children with combined respiratory forms of pollen allergy before and after three courses of treatment. The levels of G-CSF, GM-CSF, IL-10, IL-12p70, IFNγ, IL-13, IL-17A, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, TNFα, IL-8, MCP-1, MIP-1β were m...

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Autores principales:	Yu. N. Emelina, A. V. Zurochka
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	cytokines cytokines ratio indexes allergen-specific immunotherapy hay fever Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c4fb4c0ef4834e468fb40f957bbd2840
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spelling	oai:doaj.org-article:c4fb4c0ef4834e468fb40f957bbd28402021-11-18T08:03:45ZCYTOKINE CONTENTS IN NASAL SECRETIONS OF CHILDREN WITH COMBINED FORMS OF RESPIRATORY POLLEN ALLERGY BEFORE AND AFTER THREE COURSES OF SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY1563-06252313-741X10.15789/1563-0625-2016-5-443-450https://doaj.org/article/c4fb4c0ef4834e468fb40f957bbd28402016-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1068https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWe studied clinical efficacy of sublingual immunotherapy in children with combined respiratory forms of pollen allergy before and after three courses of treatment. The levels of G-CSF, GM-CSF, IL-10, IL-12p70, IFNγ, IL-13, IL-17A, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, TNFα, IL-8, MCP-1, MIP-1β were measured in nasal secretions. In remission state, the children with combined forms of respiratory allergy to pollen allergens showed local signs of chronic inflammatory process (in the nasal mucosa) associated with disturbed immune response, with increased synthesis of proinflammatory cytokines and decreased production anti-inflammatory cytokines, as well as enhanced reactions aimed for allergen elimination. Following clinical success of sublingual immunotherapy, we have shown a reduction in immunological imbalance, due to decreased activity of the systems modulating severity of inflammation and production of pro-inflammatory cytokines.Yu. N. EmelinaA. V. ZurochkaSPb RAACIarticlecytokinescytokines ratio indexesallergen-specific immunotherapyhay feverImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 5, Pp 443-450 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines cytokines ratio indexes allergen-specific immunotherapy hay fever Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines cytokines ratio indexes allergen-specific immunotherapy hay fever Immunologic diseases. Allergy RC581-607 Yu. N. Emelina A. V. Zurochka CYTOKINE CONTENTS IN NASAL SECRETIONS OF CHILDREN WITH COMBINED FORMS OF RESPIRATORY POLLEN ALLERGY BEFORE AND AFTER THREE COURSES OF SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY
description	We studied clinical efficacy of sublingual immunotherapy in children with combined respiratory forms of pollen allergy before and after three courses of treatment. The levels of G-CSF, GM-CSF, IL-10, IL-12p70, IFNγ, IL-13, IL-17A, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, TNFα, IL-8, MCP-1, MIP-1β were measured in nasal secretions. In remission state, the children with combined forms of respiratory allergy to pollen allergens showed local signs of chronic inflammatory process (in the nasal mucosa) associated with disturbed immune response, with increased synthesis of proinflammatory cytokines and decreased production anti-inflammatory cytokines, as well as enhanced reactions aimed for allergen elimination. Following clinical success of sublingual immunotherapy, we have shown a reduction in immunological imbalance, due to decreased activity of the systems modulating severity of inflammation and production of pro-inflammatory cytokines.
format	article
author	Yu. N. Emelina A. V. Zurochka
author_facet	Yu. N. Emelina A. V. Zurochka
author_sort	Yu. N. Emelina
title	CYTOKINE CONTENTS IN NASAL SECRETIONS OF CHILDREN WITH COMBINED FORMS OF RESPIRATORY POLLEN ALLERGY BEFORE AND AFTER THREE COURSES OF SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY
title_short	CYTOKINE CONTENTS IN NASAL SECRETIONS OF CHILDREN WITH COMBINED FORMS OF RESPIRATORY POLLEN ALLERGY BEFORE AND AFTER THREE COURSES OF SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY
title_full	CYTOKINE CONTENTS IN NASAL SECRETIONS OF CHILDREN WITH COMBINED FORMS OF RESPIRATORY POLLEN ALLERGY BEFORE AND AFTER THREE COURSES OF SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY
title_fullStr	CYTOKINE CONTENTS IN NASAL SECRETIONS OF CHILDREN WITH COMBINED FORMS OF RESPIRATORY POLLEN ALLERGY BEFORE AND AFTER THREE COURSES OF SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY
title_full_unstemmed	CYTOKINE CONTENTS IN NASAL SECRETIONS OF CHILDREN WITH COMBINED FORMS OF RESPIRATORY POLLEN ALLERGY BEFORE AND AFTER THREE COURSES OF SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY
title_sort	cytokine contents in nasal secretions of children with combined forms of respiratory pollen allergy before and after three courses of sublingual allergen-specific immunotherapy
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/c4fb4c0ef4834e468fb40f957bbd2840
work_keys_str_mv	AT yunemelina cytokinecontentsinnasalsecretionsofchildrenwithcombinedformsofrespiratorypollenallergybeforeandafterthreecoursesofsublingualallergenspecificimmunotherapy AT avzurochka cytokinecontentsinnasalsecretionsofchildrenwithcombinedformsofrespiratorypollenallergybeforeandafterthreecoursesofsublingualallergenspecificimmunotherapy
_version_	1718422446054309888

CYTOKINE CONTENTS IN NASAL SECRETIONS OF CHILDREN WITH COMBINED FORMS OF RESPIRATORY POLLEN ALLERGY BEFORE AND AFTER THREE COURSES OF SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY

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