Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla.

Deuterium Magnetic Resonance Spectroscopy (DMRS) is a non-invasive technique that allows the detection of deuterated compounds in vivo. DMRS has a large potential to analyze uptake, perfusion, washout or metabolism, since deuterium is a stable isotope and therefore does not decay during biologic pro...

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Autores principales:	Benedikt Hartmann, Max Müller, Lisa Seyler, Tobias Bäuerle, Tobias Wilferth, Nikolai Avdievitch, Loreen Ruhm, Anke Henning, Alexei Lesiv, Pavel Ivashkin, Michael Uder, Armin M Nagel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c4fbbe8fbc5a4bb0bdf2004e08926163
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spelling	oai:doaj.org-article:c4fbbe8fbc5a4bb0bdf2004e089261632021-12-02T20:15:49ZFeasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla.1932-620310.1371/journal.pone.0252935https://doaj.org/article/c4fbbe8fbc5a4bb0bdf2004e089261632021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252935https://doaj.org/toc/1932-6203Deuterium Magnetic Resonance Spectroscopy (DMRS) is a non-invasive technique that allows the detection of deuterated compounds in vivo. DMRS has a large potential to analyze uptake, perfusion, washout or metabolism, since deuterium is a stable isotope and therefore does not decay during biologic processing of a deuterium labelled substance. Moreover, DMRS allows the distinction between different deuterated substances. In this work, we performed DMRS of deuterated 3-O-Methylglucose (OMG). OMG is a non-metabolizable glucose analog which is transported similar to D-glucose. DMRS of OMG was performed in phantom and in vivo measurements using a preclinical 7 Tesla MRI system. The chemical shift (3.51 ± 0.1 ppm) and relaxation times were determined. OMG was injected intravenously and spectra were acquired over a period of one hour to monitor the time evolution of the deuterium signal in tumor-bearing rats. The increase and washout of OMG could be observed. Three different exponential functions were compared in terms of how well they describe the OMG washout. A mono-exponential model with offset seems to describe the observed time course best with a time constant of 1910 ± 770 s and an offset of 2.5 ± 1.2 mmol/l (mean ± std, N = 3). Chemical shift imaging could be performed with a voxel size of 7.1 mm x 7.1 mm x 7.9 mm. The feasibility of DMRS with deuterium labelled OMG could be demonstrated. These data might serve as basis for future studies that aim to characterize glucose transport using DMRS.Benedikt HartmannMax MüllerLisa SeylerTobias BäuerleTobias WilferthNikolai AvdievitchLoreen RuhmAnke HenningAlexei LesivPavel IvashkinMichael UderArmin M NagelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252935 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Benedikt Hartmann Max Müller Lisa Seyler Tobias Bäuerle Tobias Wilferth Nikolai Avdievitch Loreen Ruhm Anke Henning Alexei Lesiv Pavel Ivashkin Michael Uder Armin M Nagel Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla.
description	Deuterium Magnetic Resonance Spectroscopy (DMRS) is a non-invasive technique that allows the detection of deuterated compounds in vivo. DMRS has a large potential to analyze uptake, perfusion, washout or metabolism, since deuterium is a stable isotope and therefore does not decay during biologic processing of a deuterium labelled substance. Moreover, DMRS allows the distinction between different deuterated substances. In this work, we performed DMRS of deuterated 3-O-Methylglucose (OMG). OMG is a non-metabolizable glucose analog which is transported similar to D-glucose. DMRS of OMG was performed in phantom and in vivo measurements using a preclinical 7 Tesla MRI system. The chemical shift (3.51 ± 0.1 ppm) and relaxation times were determined. OMG was injected intravenously and spectra were acquired over a period of one hour to monitor the time evolution of the deuterium signal in tumor-bearing rats. The increase and washout of OMG could be observed. Three different exponential functions were compared in terms of how well they describe the OMG washout. A mono-exponential model with offset seems to describe the observed time course best with a time constant of 1910 ± 770 s and an offset of 2.5 ± 1.2 mmol/l (mean ± std, N = 3). Chemical shift imaging could be performed with a voxel size of 7.1 mm x 7.1 mm x 7.9 mm. The feasibility of DMRS with deuterium labelled OMG could be demonstrated. These data might serve as basis for future studies that aim to characterize glucose transport using DMRS.
format	article
author	Benedikt Hartmann Max Müller Lisa Seyler Tobias Bäuerle Tobias Wilferth Nikolai Avdievitch Loreen Ruhm Anke Henning Alexei Lesiv Pavel Ivashkin Michael Uder Armin M Nagel
author_facet	Benedikt Hartmann Max Müller Lisa Seyler Tobias Bäuerle Tobias Wilferth Nikolai Avdievitch Loreen Ruhm Anke Henning Alexei Lesiv Pavel Ivashkin Michael Uder Armin M Nagel
author_sort	Benedikt Hartmann
title	Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla.
title_short	Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla.
title_full	Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla.
title_fullStr	Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla.
title_full_unstemmed	Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla.
title_sort	feasibility of deuterium magnetic resonance spectroscopy of 3-o-methylglucose at 7 tesla.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c4fbbe8fbc5a4bb0bdf2004e08926163
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Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla.

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