Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity

A. Rouf Banday et al. report targeting alternative splicing of APOBEC3B as a strategy to modulate APOBEC-mediated mutagenesis in cancers. Higher expression of the mutagenic APOBEC3B isoform predicted shorter progression-free survival in bladder cancer patients. Expression of this mutagenic isoform c...

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Autores principales:	A. Rouf Banday, Olusegun O. Onabajo, Seraph Han-Yin Lin, Adeola Obajemu, Joselin M. Vargas, Krista A. Delviks-Frankenberry, Philippe Lamy, Ariunaa Bayanjargal, Clara Zettelmeyer, Oscar Florez-Vargas, Vinay K. Pathak, Lars Dyrskjøt, Ludmila Prokunina-Olsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c4fee0bc579f4d40a8783a55e109bac9
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spelling	oai:doaj.org-article:c4fee0bc579f4d40a8783a55e109bac92021-12-02T17:04:04ZTargeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity10.1038/s42003-021-01844-52399-3642https://doaj.org/article/c4fee0bc579f4d40a8783a55e109bac92021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01844-5https://doaj.org/toc/2399-3642A. Rouf Banday et al. report targeting alternative splicing of APOBEC3B as a strategy to modulate APOBEC-mediated mutagenesis in cancers. Higher expression of the mutagenic APOBEC3B isoform predicted shorter progression-free survival in bladder cancer patients. Expression of this mutagenic isoform could be decreased by inducing skipping of APOBEC3B exon 5 in cells treated with SF3B1 inhibitor or splice-switching oligos.A. Rouf BandayOlusegun O. OnabajoSeraph Han-Yin LinAdeola ObajemuJoselin M. VargasKrista A. Delviks-FrankenberryPhilippe LamyAriunaa BayanjargalClara ZettelmeyerOscar Florez-VargasVinay K. PathakLars DyrskjøtLudmila Prokunina-OlssonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 A. Rouf Banday Olusegun O. Onabajo Seraph Han-Yin Lin Adeola Obajemu Joselin M. Vargas Krista A. Delviks-Frankenberry Philippe Lamy Ariunaa Bayanjargal Clara Zettelmeyer Oscar Florez-Vargas Vinay K. Pathak Lars Dyrskjøt Ludmila Prokunina-Olsson Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity
description	A. Rouf Banday et al. report targeting alternative splicing of APOBEC3B as a strategy to modulate APOBEC-mediated mutagenesis in cancers. Higher expression of the mutagenic APOBEC3B isoform predicted shorter progression-free survival in bladder cancer patients. Expression of this mutagenic isoform could be decreased by inducing skipping of APOBEC3B exon 5 in cells treated with SF3B1 inhibitor or splice-switching oligos.
format	article
author	A. Rouf Banday Olusegun O. Onabajo Seraph Han-Yin Lin Adeola Obajemu Joselin M. Vargas Krista A. Delviks-Frankenberry Philippe Lamy Ariunaa Bayanjargal Clara Zettelmeyer Oscar Florez-Vargas Vinay K. Pathak Lars Dyrskjøt Ludmila Prokunina-Olsson
author_facet	A. Rouf Banday Olusegun O. Onabajo Seraph Han-Yin Lin Adeola Obajemu Joselin M. Vargas Krista A. Delviks-Frankenberry Philippe Lamy Ariunaa Bayanjargal Clara Zettelmeyer Oscar Florez-Vargas Vinay K. Pathak Lars Dyrskjøt Ludmila Prokunina-Olsson
author_sort	A. Rouf Banday
title	Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity
title_short	Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity
title_full	Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity
title_fullStr	Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity
title_full_unstemmed	Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity
title_sort	targeting natural splicing plasticity of apobec3b restricts its expression and mutagenic activity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c4fee0bc579f4d40a8783a55e109bac9
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Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity

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