Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity

Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity

A. Rouf Banday et al. report targeting alternative splicing of APOBEC3B as a strategy to modulate APOBEC-mediated mutagenesis in cancers. Higher expression of the mutagenic APOBEC3B isoform predicted shorter progression-free survival in bladder cancer patients. Expression of this mutagenic isoform c...

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Autores principales: A. Rouf Banday, Olusegun O. Onabajo, Seraph Han-Yin Lin, Adeola Obajemu, Joselin M. Vargas, Krista A. Delviks-Frankenberry, Philippe Lamy, Ariunaa Bayanjargal, Clara Zettelmeyer, Oscar Florez-Vargas, Vinay K. Pathak, Lars Dyrskjøt, Ludmila Prokunina-Olsson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/c4fee0bc579f4d40a8783a55e109bac9
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