Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge

Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge

A previous human HIV-1 vaccine clinical trial, boosting with HIV envelope protein from two strains, demonstrated moderate vaccine efficacy. Here, Bradleyet al. show that a pentavalent HIV envelope protein boost improves protection from viral challenge in non-human primates and they identify immune c...

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Autores principales: Todd Bradley, Justin Pollara, Sampa Santra, Nathan Vandergrift, Srivamshi Pittala, Chris Bailey-Kellogg, Xiaoying Shen, Robert Parks, Derrick Goodman, Amanda Eaton, Harikrishnan Balachandran, Linh V. Mach, Kevin O. Saunders, Joshua A. Weiner, Richard Scearce, Laura L. Sutherland, Sanjay Phogat, Jim Tartaglia, Steven G. Reed, Shiu-Lok Hu, James F. Theis, Abraham Pinter, David C. Montefiori, Thomas B. Kepler, Kristina K. Peachman, Mangala Rao, Nelson L. Michael, Todd J. Suscovich, Galit Alter, Margaret E. Ackerman, M. Anthony Moody, Hua-Xin Liao, Georgia Tomaras, Guido Ferrari, Bette T. Korber, Barton F. Haynes
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/c5007d852a844f28b824be4c091a1102
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spelling oai:doaj.org-article:c5007d852a844f28b824be4c091a11022021-12-02T17:06:03ZPentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge10.1038/ncomms157112041-1723https://doaj.org/article/c5007d852a844f28b824be4c091a11022017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15711https://doaj.org/toc/2041-1723A previous human HIV-1 vaccine clinical trial, boosting with HIV envelope protein from two strains, demonstrated moderate vaccine efficacy. Here, Bradleyet al. show that a pentavalent HIV envelope protein boost improves protection from viral challenge in non-human primates and they identify immune correlates of protection.Todd BradleyJustin PollaraSampa SantraNathan VandergriftSrivamshi PittalaChris Bailey-KelloggXiaoying ShenRobert ParksDerrick GoodmanAmanda EatonHarikrishnan BalachandranLinh V. MachKevin O. SaundersJoshua A. WeinerRichard ScearceLaura L. SutherlandSanjay PhogatJim TartagliaSteven G. ReedShiu-Lok HuJames F. TheisAbraham PinterDavid C. MontefioriThomas B. KeplerKristina K. PeachmanMangala RaoNelson L. MichaelTodd J. SuscovichGalit AlterMargaret E. AckermanM. Anthony MoodyHua-Xin LiaoGeorgia TomarasGuido FerrariBette T. KorberBarton F. HaynesNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Todd Bradley
Justin Pollara
Sampa Santra
Nathan Vandergrift
Srivamshi Pittala
Chris Bailey-Kellogg
Xiaoying Shen
Robert Parks
Derrick Goodman
Amanda Eaton
Harikrishnan Balachandran
Linh V. Mach
Kevin O. Saunders
Joshua A. Weiner
Richard Scearce
Laura L. Sutherland
Sanjay Phogat
Jim Tartaglia
Steven G. Reed
Shiu-Lok Hu
James F. Theis
Abraham Pinter
David C. Montefiori
Thomas B. Kepler
Kristina K. Peachman
Mangala Rao
Nelson L. Michael
Todd J. Suscovich
Galit Alter
Margaret E. Ackerman
M. Anthony Moody
Hua-Xin Liao
Georgia Tomaras
Guido Ferrari
Bette T. Korber
Barton F. Haynes
Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge
description A previous human HIV-1 vaccine clinical trial, boosting with HIV envelope protein from two strains, demonstrated moderate vaccine efficacy. Here, Bradleyet al. show that a pentavalent HIV envelope protein boost improves protection from viral challenge in non-human primates and they identify immune correlates of protection.
format article
author Todd Bradley
Justin Pollara
Sampa Santra
Nathan Vandergrift
Srivamshi Pittala
Chris Bailey-Kellogg
Xiaoying Shen
Robert Parks
Derrick Goodman
Amanda Eaton
Harikrishnan Balachandran
Linh V. Mach
Kevin O. Saunders
Joshua A. Weiner
Richard Scearce
Laura L. Sutherland
Sanjay Phogat
Jim Tartaglia
Steven G. Reed
Shiu-Lok Hu
James F. Theis
Abraham Pinter
David C. Montefiori
Thomas B. Kepler
Kristina K. Peachman
Mangala Rao
Nelson L. Michael
Todd J. Suscovich
Galit Alter
Margaret E. Ackerman
M. Anthony Moody
Hua-Xin Liao
Georgia Tomaras
Guido Ferrari
Bette T. Korber
Barton F. Haynes
author_facet Todd Bradley
Justin Pollara
Sampa Santra
Nathan Vandergrift
Srivamshi Pittala
Chris Bailey-Kellogg
Xiaoying Shen
Robert Parks
Derrick Goodman
Amanda Eaton
Harikrishnan Balachandran
Linh V. Mach
Kevin O. Saunders
Joshua A. Weiner
Richard Scearce
Laura L. Sutherland
Sanjay Phogat
Jim Tartaglia
Steven G. Reed
Shiu-Lok Hu
James F. Theis
Abraham Pinter
David C. Montefiori
Thomas B. Kepler
Kristina K. Peachman
Mangala Rao
Nelson L. Michael
Todd J. Suscovich
Galit Alter
Margaret E. Ackerman
M. Anthony Moody
Hua-Xin Liao
Georgia Tomaras
Guido Ferrari
Bette T. Korber
Barton F. Haynes
author_sort Todd Bradley
title Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge
title_short Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge
title_full Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge
title_fullStr Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge
title_full_unstemmed Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge
title_sort pentavalent hiv-1 vaccine protects against simian-human immunodeficiency virus challenge
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/c5007d852a844f28b824be4c091a1102
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