Dynamic regulatory networks of T cell trajectory dissect transcriptional control of T cell state transition

Dynamic regulatory networks of T cell trajectory dissect transcriptional control of T cell state transition

T cells exhibit heterogeneous functional states, which correlate with responsiveness to immune checkpoint blockade and prognosis of tumor patients. However, the molecular regulatory mechanisms underlying the dynamic process of T cell state transition remain largely unknown. Based on single-cell tran...

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Bibliographic Details
Main Authors: Min Yan, Jing Hu, Huating Yuan, Liwen Xu, Gaoming Liao, Zedong Jiang, Jiali Zhu, Bo Pang, Yanyan Ping, Yunpeng Zhang, Yun Xiao, Xia Li
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
T cell dysfunction
state transition trajectory
dynamic regulatory network
pseudo-times
critical regulators
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/c501c08eaa224fe2b9e632b3e2cc91f3
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https://doaj.org/article/c501c08eaa224fe2b9e632b3e2cc91f3

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