Vibration direction sensitivity of the cochlea with bone conduction stimulation in guinea pigs

Abstract Sound and vibrations that cause the skull bone to vibrate can be heard as ordinary sounds and this is termed hearing by bone conduction (BC). Not all mechanisms that causes a skull vibration to result in BC hearing are known, and one such unknown is how the direction of the vibration influe...

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Autores principales:	Mingduo Zhao, Anders Fridberger, Stefan Stenfelt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c50430f59fa14640880c17394e91820a
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spelling	oai:doaj.org-article:c50430f59fa14640880c17394e91820a2021-12-02T14:06:50ZVibration direction sensitivity of the cochlea with bone conduction stimulation in guinea pigs10.1038/s41598-021-82268-32045-2322https://doaj.org/article/c50430f59fa14640880c17394e91820a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82268-3https://doaj.org/toc/2045-2322Abstract Sound and vibrations that cause the skull bone to vibrate can be heard as ordinary sounds and this is termed hearing by bone conduction (BC). Not all mechanisms that causes a skull vibration to result in BC hearing are known, and one such unknown is how the direction of the vibration influences BC hearing. This direction sensitivity was investigated by providing BC stimulation in five different directions at the vertex of the guinea pig skull. The hearing thresholds for BC stimulation was obtained in the frequency range of 2 to 20 kHz by measurements of compound action potential. During the stimulation by BC, the vibration of the cochlear promontory was measured with a three-dimensional laser Doppler vibrometer resulting in a set of unique three-dimensional velocity magnitude combinations for each threshold estimation. The sets of three-dimensional velocity magnitude at threshold were used to investigate nine different predictors of BC hearing based on cochlear promontory velocity magnitudes, six single direction (x, y and z directions in isolation, the normal to the stapes footplate, the oval to round window direction, and the cochlear base to apex direction), one linear combination of the three dimension velocity magnitudes, one square-rooted sum of the squared velocity magnitudes, and one sum of the weighted three dimensional velocity magnitudes based on a restricted minimum square error (MSE) estimation. The MSE gave the best predictions of the hearing threshold based on the cochlear promontory velocity magnitudes while using only a single direction gave the worst predictions of the hearing thresholds overall. According to the MSE estimation, at frequencies up to 8 kHz the vibration direction between the right and left side gave the greatest contribution to BC hearing in the guinea pig while at the highest frequencies measured, 16 and 20 kHz, the anteroposterior direction of the guinea pig head gave the greatest contribution.Mingduo ZhaoAnders FridbergerStefan StenfeltNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mingduo Zhao Anders Fridberger Stefan Stenfelt Vibration direction sensitivity of the cochlea with bone conduction stimulation in guinea pigs
description	Abstract Sound and vibrations that cause the skull bone to vibrate can be heard as ordinary sounds and this is termed hearing by bone conduction (BC). Not all mechanisms that causes a skull vibration to result in BC hearing are known, and one such unknown is how the direction of the vibration influences BC hearing. This direction sensitivity was investigated by providing BC stimulation in five different directions at the vertex of the guinea pig skull. The hearing thresholds for BC stimulation was obtained in the frequency range of 2 to 20 kHz by measurements of compound action potential. During the stimulation by BC, the vibration of the cochlear promontory was measured with a three-dimensional laser Doppler vibrometer resulting in a set of unique three-dimensional velocity magnitude combinations for each threshold estimation. The sets of three-dimensional velocity magnitude at threshold were used to investigate nine different predictors of BC hearing based on cochlear promontory velocity magnitudes, six single direction (x, y and z directions in isolation, the normal to the stapes footplate, the oval to round window direction, and the cochlear base to apex direction), one linear combination of the three dimension velocity magnitudes, one square-rooted sum of the squared velocity magnitudes, and one sum of the weighted three dimensional velocity magnitudes based on a restricted minimum square error (MSE) estimation. The MSE gave the best predictions of the hearing threshold based on the cochlear promontory velocity magnitudes while using only a single direction gave the worst predictions of the hearing thresholds overall. According to the MSE estimation, at frequencies up to 8 kHz the vibration direction between the right and left side gave the greatest contribution to BC hearing in the guinea pig while at the highest frequencies measured, 16 and 20 kHz, the anteroposterior direction of the guinea pig head gave the greatest contribution.
format	article
author	Mingduo Zhao Anders Fridberger Stefan Stenfelt
author_facet	Mingduo Zhao Anders Fridberger Stefan Stenfelt
author_sort	Mingduo Zhao
title	Vibration direction sensitivity of the cochlea with bone conduction stimulation in guinea pigs
title_short	Vibration direction sensitivity of the cochlea with bone conduction stimulation in guinea pigs
title_full	Vibration direction sensitivity of the cochlea with bone conduction stimulation in guinea pigs
title_fullStr	Vibration direction sensitivity of the cochlea with bone conduction stimulation in guinea pigs
title_full_unstemmed	Vibration direction sensitivity of the cochlea with bone conduction stimulation in guinea pigs
title_sort	vibration direction sensitivity of the cochlea with bone conduction stimulation in guinea pigs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c50430f59fa14640880c17394e91820a
work_keys_str_mv	AT mingduozhao vibrationdirectionsensitivityofthecochleawithboneconductionstimulationinguineapigs AT andersfridberger vibrationdirectionsensitivityofthecochleawithboneconductionstimulationinguineapigs AT stefanstenfelt vibrationdirectionsensitivityofthecochleawithboneconductionstimulationinguineapigs
_version_	1718391988986839040

Vibration direction sensitivity of the cochlea with bone conduction stimulation in guinea pigs

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