Synchronous Development of Acute Megakaryoblastic Leukaemia and Disseminated Melanoma following Treatment of a Germ Cell Tumour: A Case Report

Somatic malignant transformation of germ cell tumours is a well-described but poorly understood phenomenon. It is characterized by differentiation of pluripotent teratoma cells into somatic tumour cells. Following malignant transformation, the most common histologies are sarcomas and primitive neuro...

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Autores principales:	Veena Gullapalli, Hannah Hsu, Vanita Bhargava, Peter Presgrave
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	germ cell tumour melanoma acute megakaryocytic leukaemia tp53 somatic malignant transformation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/c5049e0f2855410fb63814629b3a2db3
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spelling	oai:doaj.org-article:c5049e0f2855410fb63814629b3a2db32021-12-02T12:40:23ZSynchronous Development of Acute Megakaryoblastic Leukaemia and Disseminated Melanoma following Treatment of a Germ Cell Tumour: A Case Report1662-657510.1159/000519663https://doaj.org/article/c5049e0f2855410fb63814629b3a2db32021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/519663https://doaj.org/toc/1662-6575Somatic malignant transformation of germ cell tumours is a well-described but poorly understood phenomenon. It is characterized by differentiation of pluripotent teratoma cells into somatic tumour cells. Following malignant transformation, the most common histologies are sarcomas and primitive neuroectodermal tumours; however, other subtypes have been recognized including melanoma, leukaemia, and renal cell carcinoma. We report a case of a 38-year-old male who had recently completed treatment for a mediastinal germ cell tumour with teratomatous components. He presented several months after completion of chemotherapy with metastatic lesions in his spine and liver accompanied with severe pancytopenia. He was subsequently diagnosed with acute megakaryoblastic leukaemia (AMKL), and a biopsy of a liver lesion was consistent with metastatic melanoma. This case illustrates the simultaneous development of 2 rare malignant entities: mediastinal germ cell tumour-associated AMKL and somatic malignant transformation to melanoma. It also highlights the importance of close surveillance to detect these metastatic sequelae and the emerging role of tumour sequencing to establish targetable pathways.Veena GullapalliHannah HsuVanita BhargavaPeter PresgraveKarger Publishersarticlegerm cell tumourmelanomaacute megakaryocytic leukaemiatp53somatic malignant transformationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCase Reports in Oncology, Vol 14, Iss 3, Pp 1638-1644 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	germ cell tumour melanoma acute megakaryocytic leukaemia tp53 somatic malignant transformation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	germ cell tumour melanoma acute megakaryocytic leukaemia tp53 somatic malignant transformation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Veena Gullapalli Hannah Hsu Vanita Bhargava Peter Presgrave Synchronous Development of Acute Megakaryoblastic Leukaemia and Disseminated Melanoma following Treatment of a Germ Cell Tumour: A Case Report
description	Somatic malignant transformation of germ cell tumours is a well-described but poorly understood phenomenon. It is characterized by differentiation of pluripotent teratoma cells into somatic tumour cells. Following malignant transformation, the most common histologies are sarcomas and primitive neuroectodermal tumours; however, other subtypes have been recognized including melanoma, leukaemia, and renal cell carcinoma. We report a case of a 38-year-old male who had recently completed treatment for a mediastinal germ cell tumour with teratomatous components. He presented several months after completion of chemotherapy with metastatic lesions in his spine and liver accompanied with severe pancytopenia. He was subsequently diagnosed with acute megakaryoblastic leukaemia (AMKL), and a biopsy of a liver lesion was consistent with metastatic melanoma. This case illustrates the simultaneous development of 2 rare malignant entities: mediastinal germ cell tumour-associated AMKL and somatic malignant transformation to melanoma. It also highlights the importance of close surveillance to detect these metastatic sequelae and the emerging role of tumour sequencing to establish targetable pathways.
format	article
author	Veena Gullapalli Hannah Hsu Vanita Bhargava Peter Presgrave
author_facet	Veena Gullapalli Hannah Hsu Vanita Bhargava Peter Presgrave
author_sort	Veena Gullapalli
title	Synchronous Development of Acute Megakaryoblastic Leukaemia and Disseminated Melanoma following Treatment of a Germ Cell Tumour: A Case Report
title_short	Synchronous Development of Acute Megakaryoblastic Leukaemia and Disseminated Melanoma following Treatment of a Germ Cell Tumour: A Case Report
title_full	Synchronous Development of Acute Megakaryoblastic Leukaemia and Disseminated Melanoma following Treatment of a Germ Cell Tumour: A Case Report
title_fullStr	Synchronous Development of Acute Megakaryoblastic Leukaemia and Disseminated Melanoma following Treatment of a Germ Cell Tumour: A Case Report
title_full_unstemmed	Synchronous Development of Acute Megakaryoblastic Leukaemia and Disseminated Melanoma following Treatment of a Germ Cell Tumour: A Case Report
title_sort	synchronous development of acute megakaryoblastic leukaemia and disseminated melanoma following treatment of a germ cell tumour: a case report
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/c5049e0f2855410fb63814629b3a2db3
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Synchronous Development of Acute Megakaryoblastic Leukaemia and Disseminated Melanoma following Treatment of a Germ Cell Tumour: A Case Report

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