Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials

Peptide-based filamentous assemblies are successfully used for generation of structurally ordered materials, but their de novo design and structural characterization is challenging. Here, the authors provide a strategy for the design of self-assembling peptide nanotubes based on modifications of an...

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Autores principales:	Fengbin Wang, Ordy Gnewou, Charles Modlin, Leticia C. Beltran, Chunfu Xu, Zhangli Su, Puneet Juneja, Gevorg Grigoryan, Edward H. Egelman, Vincent P. Conticello
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c50837dc2bd4499eb00831a096021fb5
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spelling	oai:doaj.org-article:c50837dc2bd4499eb00831a096021fb52021-12-02T13:51:03ZStructural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials10.1038/s41467-020-20689-w2041-1723https://doaj.org/article/c50837dc2bd4499eb00831a096021fb52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20689-whttps://doaj.org/toc/2041-1723Peptide-based filamentous assemblies are successfully used for generation of structurally ordered materials, but their de novo design and structural characterization is challenging. Here, the authors provide a strategy for the design of self-assembling peptide nanotubes based on modifications of an arginine clasp interaction motif, and report the cryo-EM structures of seven designed nanotubes.Fengbin WangOrdy GnewouCharles ModlinLeticia C. BeltranChunfu XuZhangli SuPuneet JunejaGevorg GrigoryanEdward H. EgelmanVincent P. ConticelloNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fengbin Wang Ordy Gnewou Charles Modlin Leticia C. Beltran Chunfu Xu Zhangli Su Puneet Juneja Gevorg Grigoryan Edward H. Egelman Vincent P. Conticello Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials
description	Peptide-based filamentous assemblies are successfully used for generation of structurally ordered materials, but their de novo design and structural characterization is challenging. Here, the authors provide a strategy for the design of self-assembling peptide nanotubes based on modifications of an arginine clasp interaction motif, and report the cryo-EM structures of seven designed nanotubes.
format	article
author	Fengbin Wang Ordy Gnewou Charles Modlin Leticia C. Beltran Chunfu Xu Zhangli Su Puneet Juneja Gevorg Grigoryan Edward H. Egelman Vincent P. Conticello
author_facet	Fengbin Wang Ordy Gnewou Charles Modlin Leticia C. Beltran Chunfu Xu Zhangli Su Puneet Juneja Gevorg Grigoryan Edward H. Egelman Vincent P. Conticello
author_sort	Fengbin Wang
title	Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials
title_short	Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials
title_full	Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials
title_fullStr	Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials
title_full_unstemmed	Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials
title_sort	structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c50837dc2bd4499eb00831a096021fb5
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Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials

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