Association between serotonin transporter gene polymorphisms and heroin dependence: a meta-analytic study

Pao-Yen Lin,* Yi-Shan Wu* Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan *These authors contributed equally to this work Background: Studies have examined the association between heroin dependence and serot...

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Autores principales:	Lin PY, Wu YS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	ethnicity heroin polymorphism serotonin transporter STin2 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c50f82ac83474fe9beacc843ca47cb14
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spelling	oai:doaj.org-article:c50f82ac83474fe9beacc843ca47cb142021-12-02T03:15:02ZAssociation between serotonin transporter gene polymorphisms and heroin dependence: a meta-analytic study1178-2021https://doaj.org/article/c50f82ac83474fe9beacc843ca47cb142016-11-01T00:00:00Zhttps://www.dovepress.com/association-between-serotonin-transporter-gene-polymorphisms-and-heroi-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Pao-Yen Lin,* Yi-Shan Wu* Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan *These authors contributed equally to this work Background: Studies have examined the association between heroin dependence and serotonin transporter gene polymorphisms but yielded inconsistent results. The purpose of current study is to determine the overall effect of these polymorphisms on the risk for heroin dependence through a meta-analytic method.Methods: A meta-analysis was conducted to examine the association of heroin dependence with two common polymorphisms of serotonin transporter gene, in the promoter (5-hydroxytryptamine transporter-linked promotor region [5-httlpr]) and intron 2 (a various number tandem repeat in serotonin transporter intron 2 [STin2]). Data from studies with 5-httlpr (6 studies) and STin2 (8 studies) were synthesized by random effects model.Results: In the analysis, heroin dependence was found to be significantly associated with the S allele of 5-httlpr (odds ratio [OR] =1.22, 95% confidence interval [CI] =1.08–1.41, P=0.002). The association between the S allele of 5-httlpr and heroin dependence was significant in Caucasian subjects (OR =1.37, 95% CI =1.12–1.68, P=0.003), but not in non-Caucasian subjects. On the other hand, no association with STin2 polymorphism was found (OR =1.14, 95% CI =0.91–1.42, P=0.242).Conclusion: The results suggest an ethnic-specific effect of the 5-httlpr polymorphism on the risk for heroin dependence, but the influence of the genetic variance in the patients with comorbidities or intermediate phenotypes of heroin dependence needs to be further examined. Keywords: ethnicity, heroin, polymorphism, serotonin transporter, STin2Lin PYWu YSDove Medical Pressarticleethnicityheroinpolymorphismserotonin transporterSTin2Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 3061-3067 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	ethnicity heroin polymorphism serotonin transporter STin2 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	ethnicity heroin polymorphism serotonin transporter STin2 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Lin PY Wu YS Association between serotonin transporter gene polymorphisms and heroin dependence: a meta-analytic study
description	Pao-Yen Lin,* Yi-Shan Wu* Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan *These authors contributed equally to this work Background: Studies have examined the association between heroin dependence and serotonin transporter gene polymorphisms but yielded inconsistent results. The purpose of current study is to determine the overall effect of these polymorphisms on the risk for heroin dependence through a meta-analytic method.Methods: A meta-analysis was conducted to examine the association of heroin dependence with two common polymorphisms of serotonin transporter gene, in the promoter (5-hydroxytryptamine transporter-linked promotor region [5-httlpr]) and intron 2 (a various number tandem repeat in serotonin transporter intron 2 [STin2]). Data from studies with 5-httlpr (6 studies) and STin2 (8 studies) were synthesized by random effects model.Results: In the analysis, heroin dependence was found to be significantly associated with the S allele of 5-httlpr (odds ratio [OR] =1.22, 95% confidence interval [CI] =1.08–1.41, P=0.002). The association between the S allele of 5-httlpr and heroin dependence was significant in Caucasian subjects (OR =1.37, 95% CI =1.12–1.68, P=0.003), but not in non-Caucasian subjects. On the other hand, no association with STin2 polymorphism was found (OR =1.14, 95% CI =0.91–1.42, P=0.242).Conclusion: The results suggest an ethnic-specific effect of the 5-httlpr polymorphism on the risk for heroin dependence, but the influence of the genetic variance in the patients with comorbidities or intermediate phenotypes of heroin dependence needs to be further examined. Keywords: ethnicity, heroin, polymorphism, serotonin transporter, STin2
format	article
author	Lin PY Wu YS
author_facet	Lin PY Wu YS
author_sort	Lin PY
title	Association between serotonin transporter gene polymorphisms and heroin dependence: a meta-analytic study
title_short	Association between serotonin transporter gene polymorphisms and heroin dependence: a meta-analytic study
title_full	Association between serotonin transporter gene polymorphisms and heroin dependence: a meta-analytic study
title_fullStr	Association between serotonin transporter gene polymorphisms and heroin dependence: a meta-analytic study
title_full_unstemmed	Association between serotonin transporter gene polymorphisms and heroin dependence: a meta-analytic study
title_sort	association between serotonin transporter gene polymorphisms and heroin dependence: a meta-analytic study
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/c50f82ac83474fe9beacc843ca47cb14
work_keys_str_mv	AT linpy associationbetweenserotonintransportergenepolymorphismsandheroindependenceametaanalyticstudy AT wuys associationbetweenserotonintransportergenepolymorphismsandheroindependenceametaanalyticstudy
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Association between serotonin transporter gene polymorphisms and heroin dependence: a meta-analytic study

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