Antioxidant Herbs Supplementation Inhibits Endometriosis Extension in Mice

Background: Increased oxidative stress causes inflammation and increases angiogenesis. It presumed to promote the proliferation of endometriosis tissue. Kebar grass (Biophytum petersianum) and other herbs such as green tea and Cucumis melo, which contain high antioxidants, are expected to decrease o...

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Autores principales:	Yuli Trisetiyono, Widjiati Widjiati, Syarief Thaufik Hidayat, Noor Pramono
Formato:	article
Lenguaje:	EN
Publicado:	Diponegoro University 2019
Materias:	biophytum petersianum green tea cucumis melo endometriosis antioxidant herbs Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c512b6c7007c4fb89e8afc68d6cc2313
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spelling	oai:doaj.org-article:c512b6c7007c4fb89e8afc68d6cc23132021-11-05T16:47:32ZAntioxidant Herbs Supplementation Inhibits Endometriosis Extension in Mice2503-217810.14710/jbtr.v5i2.4716https://doaj.org/article/c512b6c7007c4fb89e8afc68d6cc23132019-12-01T00:00:00Zhttps://ejournal2.undip.ac.id/index.php/jbtr/article/view/4716https://doaj.org/toc/2503-2178Background: Increased oxidative stress causes inflammation and increases angiogenesis. It presumed to promote the proliferation of endometriosis tissue. Kebar grass (Biophytum petersianum) and other herbs such as green tea and Cucumis melo, which contain high antioxidants, are expected to decrease oxidative stress, inflammation, angiogenesis, and reduced endometriosis implants. Objective: To investigate the effects of Kebar grass, green tea, and Cucumis melo to malondialdehyde serum, tumor necrosis factor alpha, and vascular endothelial growth factor expression, and the area of the endometriotic implants. Methods: Twenty-eight mice were divided into four groups, i.e., the first group of endometriosis mice was given Kebar grass extract; the second group was assigned green tea extract, the third group was given the combination of Cucumis melo extract–gliadin, and the last containing the untreated endometriosis mice as the control. Each treatment was given for 14 days. The data of MDA serum level, the area of the endometriotic implants, TNF-α, and VEGF expression were collected and analyzed. Results: The MDA serum levels of the groups treated with Kebar grass extract, green tea extract, and Cucumis melo extract – gliadin were significantly lower (p=0.001) than the control group. TNF-α expression of the groups provided with each treatment also lower than the control groups (p=0.002). However, only the administration of the Cucumis melo extract–gliadin resulted in lower VEGF expression compare with the control (p=0.017). Finally, the area of the endometriotic implants of the mice models administered with each treatment was smaller than the control group (p=0.003). Conclusion: Kebar grass as well as green tea and Cucumis melo–gliadin inhibits endometriotic implants extension by decreasing MDA serum and TNF-α expression.Yuli TrisetiyonoWidjiati WidjiatiSyarief Thaufik HidayatNoor PramonoDiponegoro Universityarticlebiophytum petersianumgreen teacucumis meloendometriosisantioxidant herbsMedicine (General)R5-920ENJournal of Biomedicine and Translational Research, Vol 5, Iss 2, Pp 53-61 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	biophytum petersianum green tea cucumis melo endometriosis antioxidant herbs Medicine (General) R5-920
spellingShingle	biophytum petersianum green tea cucumis melo endometriosis antioxidant herbs Medicine (General) R5-920 Yuli Trisetiyono Widjiati Widjiati Syarief Thaufik Hidayat Noor Pramono Antioxidant Herbs Supplementation Inhibits Endometriosis Extension in Mice
description	Background: Increased oxidative stress causes inflammation and increases angiogenesis. It presumed to promote the proliferation of endometriosis tissue. Kebar grass (Biophytum petersianum) and other herbs such as green tea and Cucumis melo, which contain high antioxidants, are expected to decrease oxidative stress, inflammation, angiogenesis, and reduced endometriosis implants. Objective: To investigate the effects of Kebar grass, green tea, and Cucumis melo to malondialdehyde serum, tumor necrosis factor alpha, and vascular endothelial growth factor expression, and the area of the endometriotic implants. Methods: Twenty-eight mice were divided into four groups, i.e., the first group of endometriosis mice was given Kebar grass extract; the second group was assigned green tea extract, the third group was given the combination of Cucumis melo extract–gliadin, and the last containing the untreated endometriosis mice as the control. Each treatment was given for 14 days. The data of MDA serum level, the area of the endometriotic implants, TNF-α, and VEGF expression were collected and analyzed. Results: The MDA serum levels of the groups treated with Kebar grass extract, green tea extract, and Cucumis melo extract – gliadin were significantly lower (p=0.001) than the control group. TNF-α expression of the groups provided with each treatment also lower than the control groups (p=0.002). However, only the administration of the Cucumis melo extract–gliadin resulted in lower VEGF expression compare with the control (p=0.017). Finally, the area of the endometriotic implants of the mice models administered with each treatment was smaller than the control group (p=0.003). Conclusion: Kebar grass as well as green tea and Cucumis melo–gliadin inhibits endometriotic implants extension by decreasing MDA serum and TNF-α expression.
format	article
author	Yuli Trisetiyono Widjiati Widjiati Syarief Thaufik Hidayat Noor Pramono
author_facet	Yuli Trisetiyono Widjiati Widjiati Syarief Thaufik Hidayat Noor Pramono
author_sort	Yuli Trisetiyono
title	Antioxidant Herbs Supplementation Inhibits Endometriosis Extension in Mice
title_short	Antioxidant Herbs Supplementation Inhibits Endometriosis Extension in Mice
title_full	Antioxidant Herbs Supplementation Inhibits Endometriosis Extension in Mice
title_fullStr	Antioxidant Herbs Supplementation Inhibits Endometriosis Extension in Mice
title_full_unstemmed	Antioxidant Herbs Supplementation Inhibits Endometriosis Extension in Mice
title_sort	antioxidant herbs supplementation inhibits endometriosis extension in mice
publisher	Diponegoro University
publishDate	2019
url	https://doaj.org/article/c512b6c7007c4fb89e8afc68d6cc2313
work_keys_str_mv	AT yulitrisetiyono antioxidantherbssupplementationinhibitsendometriosisextensioninmice AT widjiatiwidjiati antioxidantherbssupplementationinhibitsendometriosisextensioninmice AT syariefthaufikhidayat antioxidantherbssupplementationinhibitsendometriosisextensioninmice AT noorpramono antioxidantherbssupplementationinhibitsendometriosisextensioninmice
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Antioxidant Herbs Supplementation Inhibits Endometriosis Extension in Mice

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