Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric cardia adenocarcinoma (GCA). Here, the authors identify frequent focal amplifications and ecDNAs in Chinese GCA patient samples, as well as the potential associations of these alterations with prognosis and dieta...

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Autores principales: Xue-Ke Zhao, Pengwei Xing, Xin Song, Miao Zhao, Linxuan Zhao, Yonglong Dang, Ling-Ling Lei, Rui-Hua Xu, Wen-Li Han, Pan-Pan Wang, Miao-Miao Yang, Jing-Feng Hu, Kan Zhong, Fu-You Zhou, Xue-Na Han, Chao-Long Meng, Jia-Jia Ji, Xingqi Chen, Li-Dong Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c5132783b9444c50bb09d9cbda0469c1
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spelling oai:doaj.org-article:c5132783b9444c50bb09d9cbda0469c12021-11-14T12:36:11ZFocal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma10.1038/s41467-021-26745-32041-1723https://doaj.org/article/c5132783b9444c50bb09d9cbda0469c12021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26745-3https://doaj.org/toc/2041-1723The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric cardia adenocarcinoma (GCA). Here, the authors identify frequent focal amplifications and ecDNAs in Chinese GCA patient samples, as well as the potential associations of these alterations with prognosis and dietary habits.Xue-Ke ZhaoPengwei XingXin SongMiao ZhaoLinxuan ZhaoYonglong DangLing-Ling LeiRui-Hua XuWen-Li HanPan-Pan WangMiao-Miao YangJing-Feng HuKan ZhongFu-You ZhouXue-Na HanChao-Long MengJia-Jia JiXingqi ChenLi-Dong WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xue-Ke Zhao
Pengwei Xing
Xin Song
Miao Zhao
Linxuan Zhao
Yonglong Dang
Ling-Ling Lei
Rui-Hua Xu
Wen-Li Han
Pan-Pan Wang
Miao-Miao Yang
Jing-Feng Hu
Kan Zhong
Fu-You Zhou
Xue-Na Han
Chao-Long Meng
Jia-Jia Ji
Xingqi Chen
Li-Dong Wang
Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma
description The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric cardia adenocarcinoma (GCA). Here, the authors identify frequent focal amplifications and ecDNAs in Chinese GCA patient samples, as well as the potential associations of these alterations with prognosis and dietary habits.
format article
author Xue-Ke Zhao
Pengwei Xing
Xin Song
Miao Zhao
Linxuan Zhao
Yonglong Dang
Ling-Ling Lei
Rui-Hua Xu
Wen-Li Han
Pan-Pan Wang
Miao-Miao Yang
Jing-Feng Hu
Kan Zhong
Fu-You Zhou
Xue-Na Han
Chao-Long Meng
Jia-Jia Ji
Xingqi Chen
Li-Dong Wang
author_facet Xue-Ke Zhao
Pengwei Xing
Xin Song
Miao Zhao
Linxuan Zhao
Yonglong Dang
Ling-Ling Lei
Rui-Hua Xu
Wen-Li Han
Pan-Pan Wang
Miao-Miao Yang
Jing-Feng Hu
Kan Zhong
Fu-You Zhou
Xue-Na Han
Chao-Long Meng
Jia-Jia Ji
Xingqi Chen
Li-Dong Wang
author_sort Xue-Ke Zhao
title Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma
title_short Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma
title_full Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma
title_fullStr Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma
title_full_unstemmed Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma
title_sort focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c5132783b9444c50bb09d9cbda0469c1
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AT pengweixing focalamplificationsareassociatedwithchromothripsiseventsanddiverseprognosesingastriccardiaadenocarcinoma
AT xinsong focalamplificationsareassociatedwithchromothripsiseventsanddiverseprognosesingastriccardiaadenocarcinoma
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