Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric cardia adenocarcinoma (GCA). Here, the authors identify frequent focal amplifications and ecDNAs in Chinese GCA patient samples, as well as the potential associations of these alterations with prognosis and dieta...

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Autores principales: Xue-Ke Zhao, Pengwei Xing, Xin Song, Miao Zhao, Linxuan Zhao, Yonglong Dang, Ling-Ling Lei, Rui-Hua Xu, Wen-Li Han, Pan-Pan Wang, Miao-Miao Yang, Jing-Feng Hu, Kan Zhong, Fu-You Zhou, Xue-Na Han, Chao-Long Meng, Jia-Jia Ji, Xingqi Chen, Li-Dong Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/c5132783b9444c50bb09d9cbda0469c1
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