JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML

Histone demethylase JMJD3 is known to be oncogenic in preleukemic states and T-cell acute lymphocytic leukemia. Here, the authors show that in some acute myeloid leukemia subsets, JMJD3 can actually act as a potential oncorepressor via mediation of C/EBPβ-centered transcriptional programming.

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Autores principales:	Shan-He Yu, Kang-Yong Zhu, Juan Chen, Xiang-Zhen Liu, Peng-Fei Xu, Wu Zhang, Li Yan, He-Zhou Guo, Jiang Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c51536513a7740679eae444e92adbac3
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spelling	oai:doaj.org-article:c51536513a7740679eae444e92adbac32021-12-02T15:33:45ZJMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML10.1038/s41467-018-05548-z2041-1723https://doaj.org/article/c51536513a7740679eae444e92adbac32018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05548-zhttps://doaj.org/toc/2041-1723Histone demethylase JMJD3 is known to be oncogenic in preleukemic states and T-cell acute lymphocytic leukemia. Here, the authors show that in some acute myeloid leukemia subsets, JMJD3 can actually act as a potential oncorepressor via mediation of C/EBPβ-centered transcriptional programming.Shan-He YuKang-Yong ZhuJuan ChenXiang-Zhen LiuPeng-Fei XuWu ZhangLi YanHe-Zhou GuoJiang ZhuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shan-He Yu Kang-Yong Zhu Juan Chen Xiang-Zhen Liu Peng-Fei Xu Wu Zhang Li Yan He-Zhou Guo Jiang Zhu JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML
description	Histone demethylase JMJD3 is known to be oncogenic in preleukemic states and T-cell acute lymphocytic leukemia. Here, the authors show that in some acute myeloid leukemia subsets, JMJD3 can actually act as a potential oncorepressor via mediation of C/EBPβ-centered transcriptional programming.
format	article
author	Shan-He Yu Kang-Yong Zhu Juan Chen Xiang-Zhen Liu Peng-Fei Xu Wu Zhang Li Yan He-Zhou Guo Jiang Zhu
author_facet	Shan-He Yu Kang-Yong Zhu Juan Chen Xiang-Zhen Liu Peng-Fei Xu Wu Zhang Li Yan He-Zhou Guo Jiang Zhu
author_sort	Shan-He Yu
title	JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML
title_short	JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML
title_full	JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML
title_fullStr	JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML
title_full_unstemmed	JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML
title_sort	jmjd3 facilitates c/ebpβ-centered transcriptional program to exert oncorepressor activity in aml
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c51536513a7740679eae444e92adbac3
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JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML

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