JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML

JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML

Histone demethylase JMJD3 is known to be oncogenic in preleukemic states and T-cell acute lymphocytic leukemia. Here, the authors show that in some acute myeloid leukemia subsets, JMJD3 can actually act as a potential oncorepressor via mediation of C/EBPβ-centered transcriptional programming.

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Autores principales: Shan-He Yu, Kang-Yong Zhu, Juan Chen, Xiang-Zhen Liu, Peng-Fei Xu, Wu Zhang, Li Yan, He-Zhou Guo, Jiang Zhu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/c51536513a7740679eae444e92adbac3
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