Prognostic factors determining survival after extrapelvic recurrence in endometrioid type endometrial cancer

Objective: To define the factors that determine survival after extrapelvic recurrence in patients with endometrioid type endometrial cancer (EC).objective Materials and methods: Clinicopathological and survival data of surgically treated endometrioid type EC patients who recurred outside pelvis were...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fatih Kilic, Mehmet Unsal, Caner Cakir, Dilek Yuksel, Cigdem Kilic, Riza Dur, Gunsu Kimyon Comert, Taner Turan, Osman Turkmen
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Extrapelvic recurrence Endometrioid tumor Endometrial cancer Survival Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/c51640ef41d74264bb9ad6cc67d38519
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c51640ef41d74264bb9ad6cc67d38519
record_format	dspace
spelling	oai:doaj.org-article:c51640ef41d74264bb9ad6cc67d385192021-11-18T04:44:42ZPrognostic factors determining survival after extrapelvic recurrence in endometrioid type endometrial cancer1028-455910.1016/j.tjog.2021.09.013https://doaj.org/article/c51640ef41d74264bb9ad6cc67d385192021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1028455921002539https://doaj.org/toc/1028-4559Objective: To define the factors that determine survival after extrapelvic recurrence in patients with endometrioid type endometrial cancer (EC).objective Materials and methods: Clinicopathological and survival data of surgically treated endometrioid type EC patients who recurred outside pelvis were reviewed. Patients who had non-endometrioid tumor, sarcomatous component in the final pathology and synchronous tumor were excluded. The period from surgery to recurrence was defined as time to recurrence (TTR) and the period from recurrence to death or last visit was defined as post-recurrence survival (PRS). Results: Sixty-six patients with extrapelvic recurrence were included in the study. No residual disease was achieved in all patients at initial surgery. Median TTR was 18 months (range, 2–84). Recurrence developed within 1 year in 24 (36.4%) patients and between 13 and 24 months in 22 (33.3%) patients. Fifty-three of 66 patients (80.3%) had extraabdominal recurrence. The 2-year PRS of the all cohort with extrapelvic recurrence was 56%. In the univariate analysis, advanced FIGO stage, lymph node metastasis, adnexal metastasis and short TTR were associated with diminished PRS (p < 0.05). The salvage chemotherapy for recurrence had a tendency to be associated with improved PRS in the univariate analysis. Two-year survival was 81% and 37% in the patients who received chemotherapy and radiotherapy, respectively (p = 0.057). Conclusion: Almost half of the patients with extrapelvic recurrence died of disease within 2 years. Chemotherapy seemed to be more effective than radiotherapy as the salvage therapy of extrapelvic recurrences.Fatih KilicMehmet UnsalCaner CakirDilek YukselCigdem KilicRiza DurGunsu Kimyon ComertTaner TuranOsman TurkmenElsevierarticleExtrapelvic recurrenceEndometrioid tumorEndometrial cancerSurvivalGynecology and obstetricsRG1-991ENTaiwanese Journal of Obstetrics & Gynecology, Vol 60, Iss 6, Pp 1023-1030 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Extrapelvic recurrence Endometrioid tumor Endometrial cancer Survival Gynecology and obstetrics RG1-991
spellingShingle	Extrapelvic recurrence Endometrioid tumor Endometrial cancer Survival Gynecology and obstetrics RG1-991 Fatih Kilic Mehmet Unsal Caner Cakir Dilek Yuksel Cigdem Kilic Riza Dur Gunsu Kimyon Comert Taner Turan Osman Turkmen Prognostic factors determining survival after extrapelvic recurrence in endometrioid type endometrial cancer
description	Objective: To define the factors that determine survival after extrapelvic recurrence in patients with endometrioid type endometrial cancer (EC).objective Materials and methods: Clinicopathological and survival data of surgically treated endometrioid type EC patients who recurred outside pelvis were reviewed. Patients who had non-endometrioid tumor, sarcomatous component in the final pathology and synchronous tumor were excluded. The period from surgery to recurrence was defined as time to recurrence (TTR) and the period from recurrence to death or last visit was defined as post-recurrence survival (PRS). Results: Sixty-six patients with extrapelvic recurrence were included in the study. No residual disease was achieved in all patients at initial surgery. Median TTR was 18 months (range, 2–84). Recurrence developed within 1 year in 24 (36.4%) patients and between 13 and 24 months in 22 (33.3%) patients. Fifty-three of 66 patients (80.3%) had extraabdominal recurrence. The 2-year PRS of the all cohort with extrapelvic recurrence was 56%. In the univariate analysis, advanced FIGO stage, lymph node metastasis, adnexal metastasis and short TTR were associated with diminished PRS (p < 0.05). The salvage chemotherapy for recurrence had a tendency to be associated with improved PRS in the univariate analysis. Two-year survival was 81% and 37% in the patients who received chemotherapy and radiotherapy, respectively (p = 0.057). Conclusion: Almost half of the patients with extrapelvic recurrence died of disease within 2 years. Chemotherapy seemed to be more effective than radiotherapy as the salvage therapy of extrapelvic recurrences.
format	article
author	Fatih Kilic Mehmet Unsal Caner Cakir Dilek Yuksel Cigdem Kilic Riza Dur Gunsu Kimyon Comert Taner Turan Osman Turkmen
author_facet	Fatih Kilic Mehmet Unsal Caner Cakir Dilek Yuksel Cigdem Kilic Riza Dur Gunsu Kimyon Comert Taner Turan Osman Turkmen
author_sort	Fatih Kilic
title	Prognostic factors determining survival after extrapelvic recurrence in endometrioid type endometrial cancer
title_short	Prognostic factors determining survival after extrapelvic recurrence in endometrioid type endometrial cancer
title_full	Prognostic factors determining survival after extrapelvic recurrence in endometrioid type endometrial cancer
title_fullStr	Prognostic factors determining survival after extrapelvic recurrence in endometrioid type endometrial cancer
title_full_unstemmed	Prognostic factors determining survival after extrapelvic recurrence in endometrioid type endometrial cancer
title_sort	prognostic factors determining survival after extrapelvic recurrence in endometrioid type endometrial cancer
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c51640ef41d74264bb9ad6cc67d38519
work_keys_str_mv	AT fatihkilic prognosticfactorsdeterminingsurvivalafterextrapelvicrecurrenceinendometrioidtypeendometrialcancer AT mehmetunsal prognosticfactorsdeterminingsurvivalafterextrapelvicrecurrenceinendometrioidtypeendometrialcancer AT canercakir prognosticfactorsdeterminingsurvivalafterextrapelvicrecurrenceinendometrioidtypeendometrialcancer AT dilekyuksel prognosticfactorsdeterminingsurvivalafterextrapelvicrecurrenceinendometrioidtypeendometrialcancer AT cigdemkilic prognosticfactorsdeterminingsurvivalafterextrapelvicrecurrenceinendometrioidtypeendometrialcancer AT rizadur prognosticfactorsdeterminingsurvivalafterextrapelvicrecurrenceinendometrioidtypeendometrialcancer AT gunsukimyoncomert prognosticfactorsdeterminingsurvivalafterextrapelvicrecurrenceinendometrioidtypeendometrialcancer AT tanerturan prognosticfactorsdeterminingsurvivalafterextrapelvicrecurrenceinendometrioidtypeendometrialcancer AT osmanturkmen prognosticfactorsdeterminingsurvivalafterextrapelvicrecurrenceinendometrioidtypeendometrialcancer
_version_	1718425125998559232

Prognostic factors determining survival after extrapelvic recurrence in endometrioid type endometrial cancer

Ejemplares similares