Association Between a History of Nontyphoidal Salmonella and the Risk of Systemic Lupus Erythematosus: A Population-Based, Case-Control Study
ObjectiveWe investigated the correlation between nontyphoidal Salmonella (NTS) infection and systemic lupus erythematosus (SLE) risk.MethodsThis case-control study comprised 6,517 patients with newly diagnosed SLE between 2006 and 2013. Patients without SLE were randomly selected as the control grou...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:c5182c3cb7734e79b1c9c83871bdb7ad2021-11-30T14:07:35ZAssociation Between a History of Nontyphoidal Salmonella and the Risk of Systemic Lupus Erythematosus: A Population-Based, Case-Control Study1664-322410.3389/fimmu.2021.725996https://doaj.org/article/c5182c3cb7734e79b1c9c83871bdb7ad2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.725996/fullhttps://doaj.org/toc/1664-3224ObjectiveWe investigated the correlation between nontyphoidal Salmonella (NTS) infection and systemic lupus erythematosus (SLE) risk.MethodsThis case-control study comprised 6,517 patients with newly diagnosed SLE between 2006 and 2013. Patients without SLE were randomly selected as the control group and were matched at a case-control ratio of 1:20 by age, sex, and index year. All study individuals were traced from the index date back to their NTS exposure, other relevant covariates, or to the beginning of year 2000. Conditional logistic regression analysis was used to analyze the risk of SLE with adjusted odds ratios (aORs) and 95% confidence intervals (CIs) between the NTS and control groups.ResultsThe mean age was 37.8 years in the case and control groups. Females accounted for 85.5%. The aOR of having NTS infection were significantly increased in SLE relative to controls (aOR, 9.20; 95% CI, 4.51-18.78) in 1:20 sex-age matching analysis and (aOR, 7.47; 95% CI=2.08-26.82) in propensity score matching analysis. Subgroup analysis indicated that the SLE risk was high among those who dwelled in rural areas; had rheumatoid arthritis, multiple sclerosis, or Sjogren’s syndrome; and developed intensive and severe NTS infection during admission.ConclusionsExposure to NTS infection is associated with the development of subsequent SLE in Taiwanese individuals. Severe NTS infection and other autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, or Sjogren’s syndrome also contributed to the risk of developing SLE.Ting-Yu TuChiu-Yu YehYao-Min HungYao-Min HungYao-Min HungYao-Min HungRenin ChangHsin-Hua ChenHsin-Hua ChenHsin-Hua ChenHsin-Hua ChenHsin-Hua ChenJames Cheng-Chung WeiJames Cheng-Chung WeiJames Cheng-Chung WeiFrontiers Media S.A.articlenontyphoidal Salmonellasystemic lupus erythematosusNHIRDcase-control studyimmunologyNTSImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
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DOAJ |
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EN |
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nontyphoidal Salmonella systemic lupus erythematosus NHIRD case-control study immunology NTS Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
nontyphoidal Salmonella systemic lupus erythematosus NHIRD case-control study immunology NTS Immunologic diseases. Allergy RC581-607 Ting-Yu Tu Chiu-Yu Yeh Yao-Min Hung Yao-Min Hung Yao-Min Hung Yao-Min Hung Renin Chang Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei Association Between a History of Nontyphoidal Salmonella and the Risk of Systemic Lupus Erythematosus: A Population-Based, Case-Control Study |
| description |
ObjectiveWe investigated the correlation between nontyphoidal Salmonella (NTS) infection and systemic lupus erythematosus (SLE) risk.MethodsThis case-control study comprised 6,517 patients with newly diagnosed SLE between 2006 and 2013. Patients without SLE were randomly selected as the control group and were matched at a case-control ratio of 1:20 by age, sex, and index year. All study individuals were traced from the index date back to their NTS exposure, other relevant covariates, or to the beginning of year 2000. Conditional logistic regression analysis was used to analyze the risk of SLE with adjusted odds ratios (aORs) and 95% confidence intervals (CIs) between the NTS and control groups.ResultsThe mean age was 37.8 years in the case and control groups. Females accounted for 85.5%. The aOR of having NTS infection were significantly increased in SLE relative to controls (aOR, 9.20; 95% CI, 4.51-18.78) in 1:20 sex-age matching analysis and (aOR, 7.47; 95% CI=2.08-26.82) in propensity score matching analysis. Subgroup analysis indicated that the SLE risk was high among those who dwelled in rural areas; had rheumatoid arthritis, multiple sclerosis, or Sjogren’s syndrome; and developed intensive and severe NTS infection during admission.ConclusionsExposure to NTS infection is associated with the development of subsequent SLE in Taiwanese individuals. Severe NTS infection and other autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, or Sjogren’s syndrome also contributed to the risk of developing SLE. |
| format |
article |
| author |
Ting-Yu Tu Chiu-Yu Yeh Yao-Min Hung Yao-Min Hung Yao-Min Hung Yao-Min Hung Renin Chang Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei |
| author_facet |
Ting-Yu Tu Chiu-Yu Yeh Yao-Min Hung Yao-Min Hung Yao-Min Hung Yao-Min Hung Renin Chang Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei |
| author_sort |
Ting-Yu Tu |
| title |
Association Between a History of Nontyphoidal Salmonella and the Risk of Systemic Lupus Erythematosus: A Population-Based, Case-Control Study |
| title_short |
Association Between a History of Nontyphoidal Salmonella and the Risk of Systemic Lupus Erythematosus: A Population-Based, Case-Control Study |
| title_full |
Association Between a History of Nontyphoidal Salmonella and the Risk of Systemic Lupus Erythematosus: A Population-Based, Case-Control Study |
| title_fullStr |
Association Between a History of Nontyphoidal Salmonella and the Risk of Systemic Lupus Erythematosus: A Population-Based, Case-Control Study |
| title_full_unstemmed |
Association Between a History of Nontyphoidal Salmonella and the Risk of Systemic Lupus Erythematosus: A Population-Based, Case-Control Study |
| title_sort |
association between a history of nontyphoidal salmonella and the risk of systemic lupus erythematosus: a population-based, case-control study |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/c5182c3cb7734e79b1c9c83871bdb7ad |
| work_keys_str_mv |
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